50 research outputs found
Heavy and light roles: myosin in the morphogenesis of the heart
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies
suggest that both myosin heavy-chain and myosin lightchain
proteins are required for a correctly formed heart.
Myosins are structural proteins that are not only expressed
from early stages of heart development, but when mutated
in humans they may give rise to congenital heart defects.
This review will discuss the roles of myosin, specifically
with regards to the developing heart. The expression of
each myosin protein will be described, and the effects that
altering expression has on the heart in embryogenesis in
different animal models will be discussed. The human
molecular genetics of the myosins will also be reviewed
Basics of Bose-Einstein Condensation
The review is devoted to the elucidation of the basic problems arising in the
theoretical investigation of systems with Bose-Einstein condensate.
Understanding these challenging problems is necessary for the correct
description of Bose-condensed systems. The principal problems considered in the
review are as follows: (i) What is the relation between Bose-Einstein
condensation and global gauge symmetry breaking? (ii) How to resolve the
Hohenberg-Martin dilemma of conserving versus gapless theories? (iii) How to
describe Bose-condensed systems in strong spatially random potentials? (iv)
Whether thermodynamically anomalous fluctuations in Bose systems are
admissible? (v) How to create nonground-state condensates? Detailed answers to
these questions are given in the review. As examples of nonequilibrium
condensates, three cases are described: coherent modes, turbulent superfluids,
and heterophase fluids.Comment: Review articl
Influence of turbulence on a diffuse electrical gas discharge under moderate pressures
The article of record as published may be found at https://doi.org/10.1063/1.326579Aspects of a corona discharge under the influence of a turbulent flow are considered. This problem represents an extension of the already complicated situation of discharges in very nonuniform electric fields but in nonmoving gases. Our approach is restricted to providing a qualitative and semiquantitative description of some important phenomena occurring in plasmas formed in a turbulent gas which flows through the strong nonuniform electric field present in the small corona region. These phenomena lead to interesting experimentally observable effects; in particular, they allow a substantial increase of current and power consumption in the diffuse discharge which is associated with a sharp enhancement of transport coefficients in the hydrodynamically turbulent plasma. Estimates of the relative current increase and power consumption (turbulent‐to‐laminar) can be made with the information presented. These estimates are in agreement with observations.Lady Davis Fellowship Trus
Moscow MV Lomonosov State University Radiocarbon Dates I
This material was digitized as part of a cooperative project between Radiocarbon and the University of Arizona Libraries.The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202
USE OF THROMBIN GENERATION ASSAY FOR THE EVALUATION OF COAGULATION AND ANTICOAGULANT ACTIVITY OF HEMOSTASIS SYSTEM IN PATIENTS WITH ABDOMINAL SEPSIS
Generally recognized factor, which complicates the course of sepsis, is the development of hypercoagulation syndrome. The increase of thrombin coagulation indicates on the elevation of risk of thrombus formation in microcirculation vessels, which could cause the formation of multiple organ failure. The thrombin generation assay is a new method of the evaluation of homeostasis system status. The test reflects the fermentation activity of thrombin and shows the functional condition, which arises in the interaction of procoagulant and anticoagulant. The diagnosis of generalized peritonitis had 30 patients (18 men and 12 women, aged 61±18,3 years) and they were included in the research. It was shown, that the use of thrombin generation assay in patients with the abdominal sepsis could give the well-timed analysis of hypercoagulation changes and the assessment of protein C system investment in the thrombin generation