Future teacher's artistic and sports development throughout planning events with scouting elements

Present article is aimed to detect students’, future primary school pedagogues’ knowledge and preparedness to plan extracurricular activities for younger pupils. The given research enables to learn the dynamics of the students’ enthusiasm for projecting extracurricular activities, using new components from the Scout experience in their creative work. Leading research methods of a given problem turned to be methods of theoretical analysis of pedagogical, psychological scientific literature; study of advanced pedagogical experience; survey, test task with the principles, methods and elements of Scouting; quantitative and qualitative analysis of results, processing of research results by methods of descriptive statistics. Students at Kazan pedagogical college - future primary school teachers participated in the research. The article presents the results of the diagnostics of future teachers in the context of the concepts of "creative self-development", "children's organization", "children's movement", as well as the results of the diagnostics of the readiness to plan and apply extracurricular activities in their work that develop the social competence of younger students Scout Method. The reliability of the research results is provided by: 1) the validity of the initial theoretical regulations and the analysis of the problem; 2) the presented structure of the theoretical and experimental stages of the study; 3) the use of theoretical and empirical research methods. The materials presented in the article reflect the dynamics of the pedagogical college students’, future primary school teachers, interest and readiness to plan extracurricular activities with the implementation of the children’s organization experience, which contribute to the development of creative potential and social activity of students. Practical significance consists in the fact that pedagogues in the educational process may use recommendations on projecting extracurricular activities with applying experience of children’s organizations. To detect and develop the pedagogical college students design competence, a number of pedagogical conditions for effective planning of extracurricular activities programs were established: organizational and pedagogical (information; setting goals for the proposed activity; consulting in the process of work); psychological and pedagogical (cooperation; emotional background; support for the initiative and independence of participants); didactic (methodological recommendations; use of ICT; shifting the focus from the teacher activities to the student activities)

CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis. Our data supports previous reports showing IL-17 and -23 upregulation in association with MS and potentially identify a previously unknown involvement for CCL27