11 research outputs found
The induction of heme oxygenase 1 decreases contractility in human internal thoracic artery and radial artery grafts
ObjectiveSpasm remains a potential problem encountered during the use of arterial grafts in coronary artery bypass surgery. Heme oxygenase plays a role in the control of arterial vasoreactivity. Heme oxygenase exists in 2 constitutive isoforms (heme oxygenase 2 and 3) and an inducible isoform (heme oxygenase 1). The aim of our study was to induce heme oxygenase 1 by using hemin in human internal thoracic and radial arteries and to evaluate the effect of this induction on the contractility of these arterial grafts.MethodsSegments of human arterial grafts obtained from patients undergoing isolated coronary artery bypass surgery were incubated in organ chambers for 4 hours in the presence of 10−4 mol/L hemin. Concentration-response curves to norepinephrine were obtained in control and hemin-treated arterial rings. Heme oxygenase 1 expression was evaluated by using enzyme-linked immunosorbent assays and immunohistochemical staining.ResultsThe contractility of the arterial rings to norepinephrine was significantly reduced after incubation with hemin. Zinc protoporphyrin (an inhibitor of heme oxygenase) reversed the effect of hemin, whereas the inhibitor of nitric oxide synthase had no effect. The inhibitor of soluble guanylate cyclase blocked the decrease in contractility induced by hemin. Immunohistochemical staining revealed a large expression of heme oxygenase 1 in all vascular layers of hemin-treated internal thoracic artery and radial artery rings. Enzyme-linked immunosorbent assay studies showed a significant increase in heme oxygenase 1 levels in hemin-treated internal thoracic artery and radial artery rings.ConclusionHemin caused in vitro induction of heme oxygenase 1 in human internal thoracic artery and radial artery grafts. This induction resulted in a reduced contractility to norepinephrine, partially through the cyclic guanosine monophosphate–dependent pathway. This effect was independent from nitric oxide synthesis
Case report: Primary cardiac lymphoma manifesting as superior vena cava syndrome
A 64-year-old man presented with symptoms indicative of superior vena cava syndrome. Imaging work-up revealed an obstructing right atrial mass, which was subsequently excised and diagnosed as primary cardiac lymphoma. Post-surgery, the patient showed significant clinical improvement and was started on a chemotherapy regimen with complete remission at 1 year
Femoral artery embolization of a thoracic stray bullet
Arterial bullet embolization after a thoracic gunshot wound represents a diagnostic and therapeutic challenge. The absence of an apparent exit wound should alert the clinician. Cardiac bullet injuries are mostly fatal. However, in some cases, patients may remain stable, and conservative management can be an acceptable strategy. We present a case report of a 7.62- × 39-mm thoracic stray bullet that embolized to the femoral artery
Functional classification dictates type of repair in “complex” mitral insufficiency: Application to a case of a hammock mitral valve in an adult patient
Extracorporeal life support: An effective and noninvasive way to treat acute necrotizing eosinophilic myocarditis
Image2_Case report: Primary cardiac lymphoma manifesting as superior vena cava syndrome.jpeg
A 64-year-old man presented with symptoms indicative of superior vena cava syndrome. Imaging work-up revealed an obstructing right atrial mass, which was subsequently excised and diagnosed as primary cardiac lymphoma. Post-surgery, the patient showed significant clinical improvement and was started on a chemotherapy regimen with complete remission at 1 year.</p
Image1_Case report: Primary cardiac lymphoma manifesting as superior vena cava syndrome.jpeg
A 64-year-old man presented with symptoms indicative of superior vena cava syndrome. Imaging work-up revealed an obstructing right atrial mass, which was subsequently excised and diagnosed as primary cardiac lymphoma. Post-surgery, the patient showed significant clinical improvement and was started on a chemotherapy regimen with complete remission at 1 year.</p