Sellaphora balashovae (Bacillariophyta), a new species from siberian mountain lake frolikha (Baikal region), Russia

© 2018 Magnolia Press. A new species, Sellaphora balashovae sp. nov., from Lake Frolikha is described based on light (LM) and scanning electron microscopy (SEM). The systematic position of this new species is determined based on molecular data. This species is placed in the genus Sellaphora based on chloroplast morphology, areolae covered by external hymenes, and uniseriate striae that are typical for the genus. Molecular data support this taxonomic assignment, and the new species is part of a monophyletic group with some other members of the genus Sellaphora. The new species is distinguishable from other Sellaphora species by its small size, valve shape, striae and areolae densities, striae orientation and distinctly large areolae bordering the sternum

Amyloid-β, Tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer's disease and other neurodegenerative conditions

In this review, we propose that the neurodegenerative changes in the neurochemistry of amyloid-β (Aβ) aggregation, tau phosphorylation, cytoskeleton rearrangement, oxidative stress, and lipid peroxidation in Alzheimer's disease (AD), and a number of other neurodegenerative diseases, are secondary pathological features. In fact, we believe that these phenomena represent natural compensatory mechanisms for impaired primary neurodegeneration, membrane dynamic deterioration, and/or associated failures of neurotransmission, synaptic function, and neuroplasticity. Physiologically, Aβ, lipid peroxidation, and tau protein may function to sense changes in activity-dependent membrane properties and therefore biochemically modulate membrane lipid homeostasis for more efficient synaptic action. As such, the previously proposed therapeutic tackling of amyloid, tau, oxidative stress, and other brain disease markers may have no ability to cure AD or other devastating central nervous system pathologies and peripheral nervous system diseases. This unfortunate realization provides a wake-up call to the neuroscience community, demanding open-minded approach. © 2009 - IOS

Amyloid-β, Tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer's disease and other neurodegenerative conditions

In this review, we propose that the neurodegenerative changes in the neurochemistry of amyloid-β (Aβ) aggregation, tau phosphorylation, cytoskeleton rearrangement, oxidative stress, and lipid peroxidation in Alzheimer's disease (AD), and a number of other neurodegenerative diseases, are secondary pathological features. In fact, we believe that these phenomena represent natural compensatory mechanisms for impaired primary neurodegeneration, membrane dynamic deterioration, and/or associated failures of neurotransmission, synaptic function, and neuroplasticity. Physiologically, Aβ, lipid peroxidation, and tau protein may function to sense changes in activity-dependent membrane properties and therefore biochemically modulate membrane lipid homeostasis for more efficient synaptic action. As such, the previously proposed therapeutic tackling of amyloid, tau, oxidative stress, and other brain disease markers may have no ability to cure AD or other devastating central nervous system pathologies and peripheral nervous system diseases. This unfortunate realization provides a wake-up call to the neuroscience community, demanding open-minded approach. © 2009 - IOS

Sellaphora balashovae (Bacillariophyta), a new species from siberian mountain lake frolikha (Baikal region), Russia

© 2018 Magnolia Press. A new species, Sellaphora balashovae sp. nov., from Lake Frolikha is described based on light (LM) and scanning electron microscopy (SEM). The systematic position of this new species is determined based on molecular data. This species is placed in the genus Sellaphora based on chloroplast morphology, areolae covered by external hymenes, and uniseriate striae that are typical for the genus. Molecular data support this taxonomic assignment, and the new species is part of a monophyletic group with some other members of the genus Sellaphora. The new species is distinguishable from other Sellaphora species by its small size, valve shape, striae and areolae densities, striae orientation and distinctly large areolae bordering the sternum