Fire and explosion analysis of filling station based on fuzzy mathematics and Bayesian network model

In order to explore the basic events and risk occurrence probability of fire and explosion accidents in CNG (Compressed Natural Gas) filling station, a corresponding Bayesian network risk model was established based on the fault tree of filling station. The prior probability was modified by introducing fuzzy mathematics in the process of transforming the fault tree into Bayesian network, and the posterior probability of the basic events of CNG filling station fire and explosion accidents was analyzed and calculated by GeNIe software. Finally, through case analysis, it is found out that the most dangerous factors that lead to the greatest risk of fire and explosion accidents in a filling station are: personnel misoperation, management defects, etc. After verifying the model, it shows that paying attention to the polymorphism of the base events and determining the rationality of the logical relationship between the base events can calculate the more accurate probability distribution of the base events, and at the same time provide reasonable suggestions for the accident prevention of the gas filling station

Assessing the mechanical responses for anisotropic multi-layered medium under harmonic moving load by Spectral Element Method (SEM)

© 2018 Elsevier Inc. The article is concerned with the mechanical responses of anisotropic multi-layered medium under harmonic moving load. An analytical solution for two-dimensional anisotropic multi-layered medium subjected to harmonic moving load is devoted via Spectral Element Method (SEM), while the anisotropic property is approximated as transverse isotropy. Starting with the constitutive equations of transversely isotropic body and the governing equations of motion based on the loading properties. The analytical spectral elements in the wavenumber domain are obtained according to the principle of wave superposition and Fourier transformation. Then, the spectral global stiffness matrix of the multi-layered medium is derived by assembling the nodded stiffness matrices of all layers depended on the different interlayer conditions between the adjacent layers, i.e. sliding and bonded. The corresponding analytical solutions are achieved by taking the Fourier series and Inverse Fast Fourier Transform (IFFT) algorithm. Finally, some examples are given to validate the accuracy of the proposed analytical solution, and to demonstrate the impact of both anisotropy, top layer thickness, interlayer conditions, and loading properties (velocity and natural frequency) on the mechanical response of the multi-layered medium

The densification and mechanical behaviors of large-diameter polymer-bonded explosives processed by ultrasonic-assisted powder compaction

Improving the density of parts, structural homogeneity, and mechanical properties are the most challenging issues in the PBX compaction process. In this study, the ultrasonic-assisted PBX compaction technique and equipment were introduced and designed. With this equipment, it is found that the density of compacted PBX parts increases, and the diameter expansion and density differences decrease by applying ultrasonic vibration. The influences of compaction pressure, hold time and particle size on the compaction were also analyzed. The results indicate that increasing the pressure and time, while decreasing the particle size, results in a higher density and strength of PBX parts. Then, the microstructures were analyzed to show the mechanism of density distributions. It is found that the density increase is due to the particle’s rearrangement leading to a “dense” structure and smaller particle sizes with ultrasonic vibration. Finally, the compressive modulus and strength, and the tensile fracture and strength were found to increase by applying ultrasonic vibration. These mechanical properties decrease along the radial and axial direction, indicating the surface effect of the ultrasonic vibration

Study on the effect of magnetic needle grinding process on the service properties of medical Mg-1.6Ca-2.0Zn alloy

Magnesium alloy, valued for its superior mechanical properties and biocompatibility in biomaterials, faces limitations such as rapid corrosion, poor wear resistance, and unfavorable cell adhesion. To address these challenges and enhance medical magnesium alloy development, this study investigates a magnetic needle grinding process on magnesium alloy. Mg-1.6Ca-2.0Zn alloy, prepared through powder metallurgy and T6 aging treatment, undergoes milling, and magnetic grinding using various needle sizes. The impact is assessed through Vickers hardness, residual stresses, surface roughness, friction and wear tests, electrochemical assessments, and contact angle tests. Results indicate a 22.59% microhardness increase, 30.43 MPa residual compressive stress, increased surface roughness, improved wear and corrosion resistance, and improved hydrophilia after magnetic needle grinding. This research provides a theoretical foundation for advancing medical magnesium alloy industrially

Study on laser processing of medical polyether ether ketone surface texture and its improvement on service performance

Polyether ether ketone (PEEK) has excellent chemical stability, x-ray transmittance, and elastic modulus close to human cortical bone, which can effectively reduce the stress shielding effect. Therefore, PEEK can be used as a commonly used medical bone implant material to repair damaged bones. However, due to its low surface free energy, PEEK has a certain degree of biological inertness. Surface modification methods are urgently needed to improve this problem. Laser surface texturing is expected to improve the biological inertia of PEEK materials. In this study, an ultraviolet laser with a wavelength of 355 nm was used to construct textures on the surface of PEEK materials. By biomimetic design on the surface of PEEK materials, textures similar in depth and width to the surface topography of natural bones were processed. We explore the specific improvement of corrugated texture, single line texture, and orthogonal texture on PEEK material performance, aiming at improving the service performance of PEEK material and creating conditions for better service of PEEK material in vivo. Through the evaluation of PEEK surface contact angle, friction and wear properties, and biocompatibility, the research results show that laser surface texture treatment can improve many service properties of PEEK materials

Lin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling.

Resistance to radiation therapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to breast tumorigenesis; however, the relationship between Lin28 and radioresistance remains unknown. In this study, we investigated the association of Lin28 with radiation resistance and identified the underlying mechanisms of action of Lin28 in human breast cancer cell lines. The results showed that the expression level of Lin28 was closely associated with resistance to radiation treatment. The T47D cancer cell line, which highly expresses Lin28, is more resistant to radiation than MCF7, Bcap-37 or SK-BR-3 cancer cell lines, which have low-level Lin28 expression. Transfection with Lin28 siRNA significantly led to an increase of sensitivity to radiation. By contrast, stable expression of Lin28 in breast cancer cells effectively attenuated the sensitivity to radiation treatment. Stable expression of Lin28 also significantly inhibited radiation-induced apoptosis. Moreover, further studies have shown that caspases, H2A.X and Let-7 miRNA were the molecular targets of Lin28. Stable expression of Lin28 and treatment with radiation induced H2AX expression, while inhibited p21 and γ-H2A.X. Overexpression of Let-7 enhanced the sensitivities to radiation in breast cancer cells. Taken together, these results indicate that Lin28 might be one mechanism underlying radiation resistance, and Lin28 could be a potential target for overcoming radiation resistance in breast cancer

Conjugated Electron Donor–Acceptor Hybrid Polymeric Carbon Nitride as a Photocatalyst for CO₂ Reduction

This work incorporates a variety of conjugated donor-acceptor (DA) co-monomers such as 2,6-diaminopurine (DP) into the structure of a polymeric carbon nitride (PCN) backbone using a unique nanostructure co-polymerization strategy and examines its photocatalytic activity performance in the field of photocatalytic CO2 reduction to CO and H2 under visible light irradiation. The as-synthesized samples were successfully analyzed using different characterization methods to explain their electronic and optical properties, crystal phase, microstructure, and their morphology that influenced the performance due to the interactions between the PCN and the DPco-monomer. Based on the density functional theory (DFT) calculation result, pure PCN and CNU-DP15.0 trimers (interpreted as incorporation of the co-monomer at two different positions) were extensively evaluated and exhibited remarkable structural optimization without the inclusion of any symmetry constraints (the non-modified sample derived from urea, named as CNU), and their optical and electronic properties were also manipulated to control occupation of their respective highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO). Also, co-polymerization of the donor−acceptor 2,6-diamino-purine co-monomer with PCN influenced the chemical affinities, polarities, and acid−base functions of the PCN, remarkably enhancing the photocatalytic activity for the production of CO and H2 from CO2 by 15.02-fold compared than that of the parental CNU, while also improving the selectivity

Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells.

Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to tumor relapse after chemotherapy; however, the relationship between Lin28 and chemoresistance remained unknown. In this study, we investigated the association of Lin28 with paclitaxel resistance and identified the underlying mechanisms of action of Lin28 in human breast cancer cell lines and tumor tissues. We found that the expression level of Lin28 was closely associated with the resistance to paclitaxel treatment. The T47D cancer cell line, which highly expresses Lin28, is more resistant to paclitaxel than the MCF7, Bcap-37 or SK-BR-3 cancer cell lines, which had low-level expression of Lin28. Knocking down of Lin28 in Lin28 high expression T47D cells increased the sensitivity to paclitaxel treatment, while stable expression of Lin28 in breast cancer cells effectively attenuated the sensitivity to paclitaxel treatment, resulting in a significant increase of IC50 values of paclitaxel. Transfection with Lin28 also significantly inhibited paclitaxel-induced apoptosis. We also found that Lin28 expression was dramatically increased in tumor tissues after neoadjuvant chemotherapy or in local relapse or metastatic breast cancer tissues. Moreover, further studies showed that p21, Rb and Let-7 miRNA were the molecular targets of Lin28. Overexpression of Lin28 in breast cancer cells considerably induced p21 and Rb expression and inhibited Let-7 miRNA levels. Our results indicate that Lin28 expression might be one mechanism underlying paclitaxel resistance in breast cancer, and Lin28 could be a potential target for overcoming paclitaxel resistance in breast cancer

Lin28 knockdown by siRNA increases sensitivity to radiation.

<p>T47D cells with naturally high Lin28 expression were transfected with Lin28 siRNA and then were treated with radiation at the indicated doses. Cell viability was subsequently determined by the clonogenic formation assay (<b>B, C</b>). Lin28 expression in the indicated cell lines was determined by Western blotting (<b>A</b>). β-actin expression was used as a loading control. Each data point represents the mean ± SD of three independent experiments. *p<0.05.</p

Overexpression of Lin28 decreases radiation-induced apoptosis in SK-BR-3 cell lines stably expressing Lin28.

<p>S1 and S24 cells were treated with radiation at doses ranging from 0 to 6 Gy, and apoptosis was analyzed. The empty vector-transfected cells were used as controls. (<b>A</b>)<b>.</b> Apoptosis compared with control. *, p<0.05. (<b>B</b>). Representative image of PI-Annexin V double staining examined in the S24 clone. (<b>C</b>). Expression of PARP, caspase-3 and caspase-9 proteins were determined in the indicated cells by Western blotting.</p