3 research outputs found
A Scalable Biomimetic Synthesis of Resveratrol Dimers and Systematic Evaluation of their Antioxidant Activities
An efficient synthetic route to the resveratrol oligomers quadrangularinâ
A and pallidol is reported. It features a scalable biomimetic oxidative dimerization that proceeds in excellent yield and with complete regioselectivity. A systematic evaluation of the natural products and their synthetic precursors as radicalâtrapping antioxidants has revealed that, contrary to popular belief, this mode of action is unlikely to account for their observed biological activity.HartnĂ€ckigkeit zahlt sich aus: Eine kurze Synthese der ResveratrolâOligomere Quadrangularinâ
A und Pallidol macht sich die StabilitĂ€t der von 2,6âDiâtertâbutylphenol abgeleiteten Radikalâ und der ChinonmethidâZwischenstufe zunutze. Untersuchungen dieser Verbindungen als antioxidative RadikalfĂ€nger ergaben, dass diese Eigenschaft höchstwahrscheinlich nicht die Ursache ihrer beobachteten biologischen AktivitĂ€t ist.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110868/1/3825_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/110868/2/ange_201409773_sm_miscellaneous_information.pd
Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines
A new catalyst system capable of
selective chloride functionalization
in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is
reported. A reaction optimization strategy employing ligand parametrization
led to the identification of 1,1âČ-bisÂ[bisÂ(dimethylÂamino)Âphosphino]Âferrocene
âDMAPFâ, a readily available yet previously unutilized
diphosphine, as a uniquely effective ligand for this transformation