Case report: A rare case of desmoid-type fibromatosis originating in the small intestine

BackgroundDesmoid-type fibromatosis (DF) is characterized by a rare monoclonal fibroblast proliferation that exhibits variable and unpredictable clinical presentation. DF can be classified into sporadic and hereditary types. Despite extensive research efforts, the exact etiology of DF remains elusive.Case descriptionA 31-year-old male patient presented to the hospital with a progressively growing mass in the right lower abdomen, accompanied by abdominal discomfort. Symptoms are discovered 1 week before admission. Enteroscopy revealed no evidence of colonic abnormalities, and blood tests did not indicate any abnormalities. Due to the indeterminate nature of the mass during surgery, a partial resection of the ileum and cecum was performed, followed by ileocolonic end-to-end anastomosis, with no postoperative complications. The final pathological diagnosis confirmed primary desmoid-type fibromatosis of the distal ileum (invasive fibromatosis). To effectively manage DF, we recommend a follow-up schedule for patients. This includes appointments every 3 months in the first year following surgery, followed by appointments every 6 months up to the fifth year, and then once a year thereafter. The follow-up examinations should include collection of the patient’s medical history, physical examination, blood tests, ultrasounds, CT scans, and other relevant assessments. During the first year of the follow-up period, no further treatment was administered, and the patient remained disease-free.ConclusionDesmoid-type fibromatosis (DF) originating from the small intestine is an extremely rare condition that exhibits local invasiveness and can be life-threatening. Despite its benign histology, DF has a high local recurrence rate and lacks metastatic potential. Diagnosis of DF remains challenging, especially in cases where surgical intervention is not feasible due to asymptomatic patients or partial organ impairment. In such cases, a “watchful waiting” approach is recommended as the initial treatment strategy. However, when preoperative diagnosis is difficult, surgery is typically considered the best option. Given the potential for local recurrence and the uncertain long-term prognosis, regular follow-up is necessary

Enhanced plastic deformation ability of copper matrix composites through synergistic strengthening of nano-Al2O3 and Cr particles

The commercial application of Al2O3/Cu composites (ODS copper) with high Al2O3 content is consistently restricted by their plastic deformability. In order to synergistically improve the plastic deformability of Al2O3/Cu composites, Al2O3/Cu–Cr composites with different Cr contents are prepared by internal oxidation combined with heat treatment by replacing part of the Al2O3 particles with Cr phases heat treatment. The effects of Cr content on the microstructure and plastic deformability of Al2O3/Cu–Cr composites are investigated. It is found that the nano-Al2O3 (8 nm) and Cr (25 nm) particles are uniformly distributed in the copper matrix, and both reach a semi-congruent interface with copper matrix. Meanwhile, the copper matrix undergoes a transition from a [111]Cu hard orientation to a [100]Cu soft orientation, and the increase in Cr content leads to a more pronounced degree of recrystallization in the Al2O3/Cu–Cr composites. The results of geometric phase analysis (GPA) show that the coordinated deformability between Cr and Cu is better than that between Al2O3 and Cu. The elongation of 2.5Al2O3/Cu-0.3Cr composite increased to 24.48 % from 22.47 % of the Cr-free 2.8Al2O3/Cu composite. The results of tensile strength calculations show that the tensile strength of Al2O3/Cu–Cr composites is mainly dominated by matrix strengthening and Orowan strengthening induced by Al2O3 particles, while grain strengthening, dislocation strengthening, and Orowan strengthening induced by Cr particles play a secondary role. The correlation coefficient (R2) is 0.95 after fitting the experimental and theoretical values of tensile strength of Al2O3/Cu–Cr composites

Dietary Lysozyme Alters Sow’s Gut Microbiota, Serum Immunity and Milk Metabolite Profile

The aim of current study was to determine variations in sow’s gut microbiota, serum immunity, and milk metabolite profile mediated by lysozyme supplementation. Twenty-four pregnant sows were assigned to a control group without supplementation and two treatments with 0.5 kg/t and 1.0 kg/t lysozyme provided in formula feed for 21 days (n = 8 per treatment). Microbiota analysis and metagenomic predictions were based on 16s RNA high-throughput sequencing. Milk metabolome was assessed by untargeted liquid chromatography tandem mass spectrometry. Serum biochemical indicators and immunoglobulins were also determined. Gut microbial diversity of sows receiving 1.0 kg/t lysozyme treatment was significantly reduced after the trial. Spirochaetes, Euryarchaeota, and Actinobacteria significantly increased while Firmicutes showed a remarkable reduction in 1.0 kg/t group compared with control. Lysozyme addition rebuilt sow’s gut microbiota to beneficial composition identified by reduced richness of Escherichia coli and increased abundance of Lactobacillus amylovorus. Accordingly, microbial metabolic functions including pyrimidine metabolism, purine metabolism, and amino acid related enzymes were significantly up-regulated in 1.0 kg/t group. Microbial metabolic phenotypes like the richness of Gram-positive bacteria and oxidative stress tolerance were also significantly reduced by lysozyme treatment. Serum alanine transaminase (ALT) activity and IgA levels were significantly down-regulated in the 1.0 kg/t group compared with control, but IgM levels showed a significantly increase in 1.0 kg/t group. Milk metabolites such as L-glutamine, creatine, and L-arginine showed significantly dose-dependent changes after treatment. Overall, lysozyme supplementation could effectively improve the composition, metabolic functions, and phenotypes of sow’s gut microbiota and it also benefit sows with better serum immunity and milk composition. This research could provide theoretical support for further application of lysozyme in promoting animal gut health and prevent pathogenic infections in livestock production

PPARγ/mTOR Regulates the Synthesis and Release of Prostaglandins in Ovine Trophoblast Cells in Early Pregnancy

Trophoblast cells synthesize and secrete prostaglandins (PGs), which are essential for ruminants in early gestation to recognize pregnancy. Hormones in the intrauterine environment play an important role in regulating PGs synthesis during implantation, but the underlying mechanism remains unclear. In this study, co-treatment of sheep trophoblast cells (STCs) with progesterone (P4), estradiol (E2), and interferon-tau (IFN-τ) increased the ratio of prostaglandin E2 (PGE2) to prostaglandin F2α (PGF2α) and upregulated peroxisome proliferator-activated receptor γ (PPARγ) expression, while inhibiting the mechanistic target of rapamycin (mTOR) pathway and activating cellular autophagy. Under hormone treatment, inhibition of PPARγ activity decreased the ratio of PGE2/PGF2α and cellular activity, while activating expression of the mTOR downstream marker—the phosphorylation of p70S6K (p-p70S6K). We also found that the PPARγ/mTOR pathway played an important role in regulating trophoblast cell function. Inhibition of the mTOR pathway by rapamycin increased the ratio of PGE2/PGF2α and decreased the expression of apoptosis-related proteins after inhibiting PPARγ activity. In conclusion, our findings provide new insights into the molecular mechanism of prostaglandin regulation of trophoblast cells in sheep during early pregnancy, indicating that the PPARγ/mTOR pathway plays an important role in PGs secretion and cell viability

The Impact of Air Pollution on Intestinal Microbiome of Asthmatic Children: A Panel Study

Air pollution could impact on the alteration of intestinal microbiome. Maturation of intestinal microbiome in early life played an important role in the development of allergic diseases, including asthma. Recent studies presented an increase in the evidence of association between the shift of gut microbiota and asthma. This article is aimed at exploring whether the alteration in the intestinal microbiome triggered by a short wave of air pollution could influence the colonization of bacteria that have been related to the immunological mechanisms of the asthma attack. The impact of air pollution on intestinal microbiome was assessed by longitudinal comparison. Fecal samples were collected twice for twenty-one children in clean and smog days, respectively, including eleven asthmatic children and ten healthy children. Intestinal bacteria were discriminated by using the method of 16S rRNA gene sequence. The results showed that the composition of intestinal microbiome changed between clean and smog days among all children (PERMANOVA, P=0.03). During smog days, Bifidobacteriaceae, Erysipelotrichaceae, and Clostridium sensu stricto 1 decreased, and Streptococcaceae, Porphyromonadaceae, Rikenellaceae, Bacteroidales S24-7 group, and Bacteroides increased in asthmatic children (Wilcoxon test, P<0.05), while Fusicatenibacter decreased and Rikenellaceae and Terrisporobacter increased in healthy children (Wilcoxon test, P<0.05). After controlling for food consumption, the relative abundance of some bacteria belonging to Firmicutes negatively associated with concentration of PM2.5, PM10, NO2, and SO2 (multiple linear regression, P<0.05). This study demonstrated that short wave of air pollution had an impact on the intestinal microbiome of asthmatic children. Intestinal bacteria, which have been related to immunological mechanisms of asthma attack, were also found to be associated with air pollution. This finding suggested that a short wave of air pollution may trigger asthma by impacting on intestinal bacteria

Anti-Eavesdropping by Exploiting the Space–Time Coupling in UANs

Due to the space–time coupling access, we find that anti-eavesdropping opportunities exist in underwater acoustic networks (UANs), where packets can be successfully received only by the intended receiver, but collide at the unintended receivers. These opportunities are highly spatially dependent, and this paper studies the case that linearly deployed sensor nodes directly report data toward a single collector. We found an eavesdropping ring centered around these linearly deployed sensor nodes, where the eavesdropper could steal all the reported data. Since the typical receiving-alignment-based scheduling MAC (TRAS-MAC) will expose the relative spatial information among the sensor nodes with the collector, the eavesdropper can locate the eavesdropping ring. Although moving the collector into the one-dimensional sensor node chain can degrade the eavesdropping ring to a point that constrains the eavesdropping risk, the collector’s location will be subsequently exposed to the eavesdropper. To efficiently protect the reported data and prevent the exposure of the collector’s location, we designed a slotted- and receiving-alignment-based scheduling MAC (SRAS-MAC). The NS-3 simulation results showed the effectiveness of the SRAS-MAC and the TRAS-MAC in protecting data from eavesdropping, which protect 90% of the data from eavesdropping in the one-eavesdropper case and up to 80% of data from eavesdropping in ten-eavesdropper cases. Moreover, unlike TRAS-MAC, which will expose the collector’s location, SRAS-MAC provides multiple positions for the collector to hide, and the eavesdropper cannot distinguish where it is

Thermal and arc erosion behavior of CuCr contact material based on large plastic deformation treatment

CuCr alloys are the main contact materials used in medium-voltage and high-current vacuum interrupters. In this paper, the effect of large plastic deformation on microstructure and the transverse/longitudinal thermal conductivity of CuCr30 contact material were studied. The results show that the morphology of Cr particles in CuCr30 changes from dendritic to oriented fibrous after large plastic deformation, and the longitudinal thermal conductivity of CuCr30 contact material is about 1.5 times higher than its transverse thermal conductivity. During the electrical contacting process, the mass loss of the extruded CuCr30 contact material is lower than that of as-cast CuCr30 contact material, which is directly related to the significantly higher longitudinal thermal conductivity of the extruded CuCr30 contact material. The enhancement of longitudinal thermal conductivity is beneficial to reduce the mass loss of the contact material and improve the arc erosion resistance of the contact material. The mass loss of the cathode with higher longitudinal thermal conductivity is significantly lower than that of the anode contact in extruded CuCr30 contact material

Ningdong Granule Upregulates the Striatal DA Transporter and Attenuates Stereotyped Behavior of Tourette Syndrome in Rats

This study aimed to evaluate the possible mechanism of Ningdong granule (NDG) for the treatment of Tourette syndrome (TS). The rats with stereotyped behavior were established by microinjection with TS patients’ sera; then, the model rats were divided into NDG and haloperidol (Hal) group, and the nonmedication model rats were regarded as treatment control (TS group). The stereotyped behavior of the rats was recorded, the level of dopamine (DA) in striatum, and the content of homovanillic acid (HVA) in sera were tested, and dopamine transporter (DAT) expression was measured in the study. The experimental results showed that NDG effectively inhibited the stereotyped behavior (P<0.01), decreased the levels of DA in the striatum (P<0.05), increased the content of sera HVA (P<0.01), and enhanced the protein and mRNA expression of DAT in the striatum (P<0.01). Additionally, the results also revealed Hal could improve the stereotyped behavior as well but had no remarkable influence on DAT expression and DA metabolism. In conclusion, NDG attenuates stereotyped behavior, and its mechanism of action might be associated with the upregulation of DAT expression to regulate DA metabolism in the brain

Numerical Simulation via CFD Methods of Nitrogen Flooding in Carbonate Fractured-Vuggy Reservoirs

A reservoir-scale numerical conceptual model was established according to the actual geological characteristics of a carbonate fractured-vuggy reservoir. Considering the difference in density and viscosity of fluids under reservoir conditions, CFD (computational fluid dynamic) porous medium model was applied to simulate the process of nitrogen displacement in a fractured-vuggy reservoir after water flooding. The effects of gas injection rate, injection mode, and injector–producer location relation were studied. The results show that nitrogen flooding can yield additional oil recovery of 7–15% after water flooding. Low-speed nitrogen injection is beneficial in obtaining higher oil recovery. High speed injection can expand the sweep area, but gas channeling occurs more easily. In gas–water mixed injection mode, there is fluid disturbance in the reservoir. The gas channeling is faster in low injector–high producer mode, while the high injector–low producer mode is beneficial for increasing the gas sweep range. Nevertheless, the increment of recovery is closely related to well pattern. After nitrogen flooding, there are still a lot of remaining oil distributed in the trap area of gas cap and bottom water in the reservoir that water and gas injection can’t sweep. The establishment of the numerical conceptual model compensates for the deficiency of physical simulation research, stating that only limited parameters can be simulated during experiments, and provides theoretical bases for nitrogen flooding in fractured-vuggy reservoir