MuLan: Towards a 1ppm muon lifetime measurement

The MuLan experiment will measure the lifetime of the positive muon to 1ppm. Within the Standard Model framework, this will permit a determination of the Fermi Constant to 0.5ppm. I present an update on our progress and achievements to date.Comment: 3 pages, 1 figure, contribution to the proceedings of CIPANP 2006 (May 30-June 3, 2006), Rio Grande, Puerto Ric

Composite scalars at CERN LEP: Constraining technicolor theories

LEPI and LEPII data can be used to constrain technicolor models with light, neutral pseudo-Nambu-Goldstone bosons, Pa. We use published limits on branching ratios and cross sections for final states with photons, large missing energy, jet pairs, and b bbar pairs to constrain the anomalous Pa Z0 Z0, Pa Z0 photon, and Pa photon photon couplings. From these results, we derive bounds on the size of the technicolor gauge group and the number of technifermion doublets in models such as Low-scale Technicolor

Casual Mediation Analyses with Structural Mean Models

We represent a linear structural mean model (SMM)approach for analyzing mediation of a randomized baseline intervention\u27s effect on a univariate follow-up outcome. Unlike standard mediation analyses, our approach does not assume that the mediating factor is randomly assigned to individuals (i.e., sequential ignorability). Hence, a comparison of the results of the proposed and standard approaches in with respect to mediation offers a sensitivity analyses of the sequential ignorability assumption. The G-estimation procedure for the proposed SMM represents an extension of the work on direct effects of randomized treatment effects for survival outcomes by Robins and Greenland (1994) (Section 5.0 and Appendix B) and on treatment non-adherence for continuous outcomes by TenHave et al. (2004). Simulations show good estimation and confidence interval performance under unmeasured confounding relative mediation approach. Sensitivity analyses of the sequential ignorability assumption comparing the results of the two approaches are presented in the context of two suicide/depression treatment studies

Tomographic inversion for sediment parameters in shallow water

This article discusses inversions for bottom geoacoustic properties using broadband acoustic signals obtained from explosive sources. The experimental data used for the inversions are SUS charge explosions acquired on a vertical hydrophone array during the Shelf Break Primer Experiment conducted south of New England in the Middle Atlantic Bight in August 1996. The SUS signals were analyzed for their time-frequency behavior using wavelets. The group speed dispersion curves were obtained from the wavelet scalogram of the SUS signals. A genetic algorithm (GA) was used for the inversion of sound speeds in the water column and compressional wave speeds in the sediment layers. The variations in the sound speeds in the water column were represented using empirical orthogonal functions (EOFs). A range-independent normal mode routine was used to construct the replica fields corresponding to the parameters. Comparison of group speeds for modes 1 to 9 and for a range of frequencies 8 to 200 Hz was used to arrive at the best parameter fit. An efficient hybrid optimization scheme using the GA and a Levenberg–Marquardt algorithm is presented. Linear perturbation methods were also used to “fine tune” the inversions and to obtain resolution and variance estimates. Analysis was also done to compute the degree of convergence of each of the parameters by explicitly calculating the Hessian matrices numerically. A posteriori estimation of mean and covariance was also done to obtain error estimates. Group speeds for the inverted sound speed fields provide an excellent match to the experimental data. The inverted sediment compressional speed profile compares well with in situ measurements

Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.

INTRODUCTION: Pregnant women exposed chronically to opioids smoked more cigarettes per day (CPD) and had a higher nicotine metabolite ratio (NMR), 3-hydroxycotinine/cotinine, a biomarker of nicotine metabolism and clearance, than those not receiving opioids. We examined CPD and NMR in a group of pregnant smokers, a quarter of whom were receiving opioid agonist therapy (OAT). AIMS AND METHODS: Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR. RESULTS: Half (52.4%) of the 124 women with NMR data were African American. OAT-treated women (n = 34, 27.4%; 27 receiving methadone and 7 buprenorphine) were more likely to be white (79% vs. 30%, p \u3c .001) and to have a lower mean PHQ-9 total score (2.91 [SD = 2.83] vs. 4.83 [SD = 3.82], p = .007). OAT-treated women reported smoking more CPD (9.50 [SD = 5.26] vs. 7.20 [SD = 3.65], p = .005) and had higher NMR (0.78 [SD = 0.36] vs. 0.56 [SD = 0.25], p = .001) than the non-OAT-treated group. In a linear regression analysis adjusting for race, depression severity, and CPD, NMR was greater in the OAT group (p = .025), among whom the daily methadone-equivalent dosage correlated with NMR (Spearman\u27s ρ = 0.49, p = .003). CONCLUSIONS: Consistent with the findings of Oncken et al. (2019), we found that OAT smokers smoked more and had higher NMR than non-OAT smokers. As higher NMR is associated with a reduced likelihood of smoking cessation, the effects on NMR of both pregnancy and OAT could contribute to a lower smoking cessation rate in pregnant smokers receiving chronic opioid therapy. IMPLICATIONS: We replicated the finding that the NMR is significantly greater among pregnant smokers receiving OAT than those not receiving this treatment for opioid use disorder. Furthermore, we found that the dosage of the OAT was significantly associated with the NMR level. These findings may contribute to a poorer response to smoking cessation treatment in pregnant women treated with OAT, particularly those receiving high-dose therapy, and raise the question of whether novel approaches are needed to treat smoking in this subgroup of pregnant smokers

Corticosteroids in idiopathic pulmonary fibrosis (IPF)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89998/1/white-corticosteroids_idiopathic_pulmonary.pd