Astrophysics and cosmology with a deci-hertz gravitational-wave detector: TianGO

We present the astrophysical science case for a space-based, deci-Hz gravitational-wave (GW) detector. We particularly highlight an ability in inferring a source's sky location, both when combined with a network of ground-based detectors to form a long triangulation baseline, and by itself for the early warning of merger events. Such an accurate location measurement is the key for using GW signals as standard sirens for constraining the Hubble constant. This kind of detector also opens up the possibility of testing type Ia supernovae progenitor hypotheses by constraining the merger rates of white dwarf binaries with both super- and sub-Chandrasekhar masses separately. We will discuss other scientific outcomes that can be delivered, including the precise determination of black hole spins, the constraint of structure formation in the early Universe, and the search for intermediate-mass black holes

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA.

In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage by DNA. We investigated evolutionary advantages for using DNA as the genetic material. The error rate of replication imposes a fundamental limit on the amount of information that can be stored in the genome, as mutations degrade information. We compared misincorporation rates of RNA and DNA in experimental non-enzymatic polymerization and calculated the lowest possible error rates from a thermodynamic model. Both analyses found that RNA replication was intrinsically error-prone compared to DNA, suggesting that total genomic information could increase after the transition to DNA. Analysis of the transitional RNA/DNA hybrid duplexes showed that copying RNA into DNA had similar fidelity to RNA replication, so information could be maintained during the genetic takeover. However, copying DNA into RNA was very error-prone, suggesting that attempts to return to the RNA world would result in a considerable loss of information. Therefore, the genetic takeover may have been driven by a combination of increased chemical stability, increased genome size and irreversibility

Relaxation oscillations, stability, and cavity feedback in a superradiant Raman laser

We experimentally study the relaxation oscillations and amplitude stability properties of an optical laser operating deep into the bad-cavity regime using a laser-cooled $^{87}$Rb Raman laser. By combining measurements of the laser light field with nondemolition measurements of the atomic populations, we infer the response of the gain medium represented by a collective atomic Bloch vector. The results are qualitatively explained with a simple model. Measurements and theory are extended to include the effect of intermediate repumping states on the closed-loop stability of the oscillator and the role of cavity feedback on stabilizing or enhancing relaxation oscillations. This experimental study of the stability of an optical laser operating deep into the bad-cavity regime will guide future development of superradiant lasers with ultranarrow linewidths.Comment: 9 pages, 6 figure

Gravitational waveforms of binary neutron star inspirals using post-Newtonian tidal splicing

The tidal deformations of neutron stars within an inspiraling compact binary alter the orbital dynamics, imprinting a signature on the gravitational wave signal. Modeling this signal could be done with numerical-relativity simulations, but these are too computationally expensive for many applications. Analytic post-Newtonian treatments are limited by unknown higher-order nontidal terms. This paper further builds upon the “tidal splicing” model in which post-Newtonian tidal terms are “spliced” onto numerical relativity simulations of black-hole binaries. We improve on previous treatments of tidal splicing by including spherical harmonic modes beyond the (2,2) mode, expanding the post-Newtonian expressions for tidal effects to 2.5 order, including dynamical tide corrections, and adding a partial treatment of the spin-tidal dynamics. Furthermore, instead of numerical relativity simulations, we use the spin-aligned binary black hole (BBH) surrogate model “NRHybSur3dq8” to provide the BBH waveforms that are input into the tidal slicing procedure. This allows us to construct spin-aligned, inspiraling TaylorT2 and TaylorT4 splicing waveform models that can be evaluated quickly. These models are tested against existing binary neutron star and black hole–neutron star simulations. We implement the TaylorT2 splicing model as an extension to “NRHybSur3dq8,” creating a model that we call “NRHybSur3dq8Tidal.

Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study.

BackgroundPoor socioeconomic and health-related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).MethodsThe CCSS is a retrospective cohort study with longitudinal follow-up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person-years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory-18, the Medical Outcomes Study 36-Item Short Form Health Survey, and the CCSS-Neurocognitive Questionnaire also were assessed.ResultsAmong 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all-cause late mortality rates were 0.70 (95% CI, 0.68-0.73) prior to stroke, 1.03 (95% CI, 0.73-1.46) after the first stroke, and 2.42 (95% CI, 1.48-3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4-3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7-16.8]) compared with stroke-free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4-4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1-10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2-3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1-10.5]).ConclusionsStroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134502/1/ana24584_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134502/2/ana24584.pd

Astrophysics and cosmology with a decihertz gravitational-wave detector: TianGO

We present the astrophysical science case for a space-based, decihertz gravitational-wave (GW) detector. We particularly highlight an ability to infer a source’s sky location, both when combined with a network of ground-based detectors to form a long triangulation baseline, and by itself for the early warning of merger events. Such an accurate location measurement is the key for using GW signals as standard sirens for constraining the Hubble constant. This kind of detector also opens up the possibility to test type Ia supernovae progenitor hypotheses by constraining the merger rates of white dwarf binaries with both super- and sub-Chandrasekhar masses separately. We will discuss other scientific outcomes that can be delivered, including the constraint of structure formation in the early Universe, the search for intermediate-mass black holes, the precise determination of black hole spins, the probe of binary systems’ orbital eccentricity evolution, and the detection of tertiary masses around merging binaries