27 research outputs found
Role of GeneXpert in the diagnosis of mycobacterium tuberculosis
Introduction: GeneXpert (GX) is a novel, integrated, cartridge-based, nucleic acid amplification test with an established role for rapid diagnosis of Mycobacterium tuberculosis and detection of rifampicin resistance.Aim: To evaluate the role of GX in pulmonary and extrapulmonary tuberculosis (TB) cases.Material and methods: A prospective study was conducted in the pulmonary medicine department of a tertiary care hospital after the Ethics Comittee permission. Data of 257 presumptive TB patients was retrieved for GX, acid fast bacilli smear and cul-ture (AFB smear and culture) and drug susceptibility test (DST). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of GX in diagnosis and determination of rifampicin resistance in pulmonary and extrapulmonary TB cases were calculated and compared with culture and DST results.Results: Our study included 132 pulmonary and 125 extrapulmonary cases. On the basis of clinicoradiological and microbiological correlation, diagnosis of TB was confirmed in 104 pulmonary and 103 extrapulmonary cases. Out of a total of 104 pulmonary TB cases, 73 were rifampicin-sensitive and 31 were rifampicin-resistant cases. 103 extrapulmonary TB patients included 66 rifampicin-sensitive and 37 rifampicin-resistant cases. The sensitivity, specificity, PPV, NPV of GX in diagnosis and detection of rifampicin resistance in pulmonary TB was 95%, 93%, 98%, 84% and 96%, 100%, 100%, 96%, respectively. The sensitivity, specificity, PPV, NPV of GX in diagnosis and detection of rifampicin resistance in extrapulmonary TB cases was 79%, 86%, 96%, 47% and 97%, 95%, 97%, 95%, respectively.Conclusions: GX results are superior to smear microscopy and comparable to culture with shorter turnaround time.We recom-mend using it in routine TB diagnosis as this will expedite the management of patients with presumptive TB
Diffuse Pan Bronchiolitis Presenting with Bronchiectasis: A Case Report
Diffuse Pan Bronchiolitis (DPB) is a peculiar airway disease with its pathogenesis enrooted in a complex interplay of various genetic and environmental factors. Airway inflammation, chronic airflow limitation and suppuratives in pulmonary infections are the distinctive features of this entity. It poses a close differential to
other frequently encountered pulmonary conditions like chronic bronchitis, emphysema, bronchiectasis and constrictive bronchiolitis. Deferment in diagnosis can culminate in irreversible airway remodeling and progressive respiratory failure. Hence a punctual recognition is vital. Macrolide group of drugs are prime
modality of therapy and the response to therapy is benignant. We herein describe a case of DPB with development of sequelae owing to its delayed detection
ΠΡΠ΅Π½ΠΊΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΎΡΠ³Π°Π½ΠΎΠ² Π³ΡΡΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π±ΠΈΠΎΠΏΡΠΈΠΈ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ
Computed tomography (CT) guided percutaneous procedures like the fine needle aspiration cytology (FNAC) and fine needle aspiration biopsy (FNAB) are reliable techniques for diagnosing various thoracic diseases. These modalities are used for diagnosis in suspicious lung, pleural, mediastinal and vertebral and pulmonary lesions.The aim. We conducted a study in a Pulmonary Medicine Department of tertiary care hospital to study the efficacy and safety of CT guided FNCA/FNAB in thoracic diseases.Methods. A retrospective study was conducted at a tertiary care center with Information and Ethics committee permission within a total duration of two years. The study included patients presenting with following: 1) mediastinal mass lesions, 2) pulmonary solitary pulmonary nodules/masses, 3) pulmonary cavity, cyst and consolidation of undiagnosed etiology, 4) pleural mass, nodules, loculated collections, 5) extra-pulmonary and spinal tuberculosis suspects with pre/paravertebral abscess. Procedure details, radiological images and pathological and microbiological reports were retrieved from case record book of patients available in department.Results. Study population consisted of 108 patients. Neoplastic diseases were 85 (78.70%) and Non- neoplastic diseases 23 (21.29%). In neoplastic diseases 78.82% patients had lung Cancer of which 85.07% non small cell carcinoma and 14.92% small cell lung cancer. Out of non small cell lung cancer adenocarcinoma of lung was the commonest. The most common non neoplastic diseases was tuberculosis. CT guided biopsy procedure was performed without any complications in 61.11%. The most common complication was pneumothorax (27.77%). The yield of CT guided biopsy was 98.14%.Conclusion. Percutaneous CT-guided lung biopsy is an effective, highly accurate, and safe method of obtaining tissue for the diagnosis of indeterminate pulmonary lesions especially in neoplastic diseases and tuberculosis.Π§ΡΠ΅ΡΠΊΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠ’), ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ ΡΠΎΠ½ΠΊΠΎΠΈΠ³ΠΎΠ»ΡΠ½Π°Ρ Π°ΡΠΏΠΈΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ (fine needle aspiration cytology β FNAC) ΠΈ ΡΠΎΠ½ΠΊΠΎΠΈΠ³ΠΎΠ»ΡΠ½Π°Ρ Π°ΡΠΏΠΈΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Π±ΠΈΠΎΠΏΡΠΈΡ (fine needle aspiration biopsy β FNAB), ΡΠ²Π»ΡΡΡΡΡ Π½Π°Π΄Π΅ΠΆΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΎΡΠ³Π°Π½ΠΎΠ² Π³ΡΡΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ. ΠΡΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ
, ΠΏΠ»Π΅Π²ΡΡ, ΡΡΠ΅Π΄ΠΎΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΠ·Π²ΠΎΠ½ΠΎΡΠ½ΠΈΠΊΠ° ΠΈ Π»Π΅Π³ΠΊΠΈΡ
.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΏΡΠ»ΡΠΌΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΠΈΡΡ ΡΡΠ΅ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ, ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ FNCA / FNAB ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΠ’ ΠΏΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² Π³ΡΡΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π Π΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2 Π»Π΅Ρ Π² ΡΠ΅Π½ΡΡΠ΅ ΡΡΠ΅ΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ Ρ ΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΎΠΌΠΈΡΠ΅ΡΠ° ΠΏΠΎ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΈ ΡΡΠΈΠΊΠ΅. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ: 1) Ρ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ ΡΡΠ΅Π΄ΠΎΡΡΠ΅Π½ΠΈΡ; 2) Ρ Π»Π΅Π³ΠΎΡΠ½ΡΠΌΠΈ ΡΠΎΠ»ΠΈΡΠ°ΡΠ½ΡΠΌΠΈ ΡΠ·Π»Π°ΠΌΠΈ / Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ; 3) Ρ ΠΏΠΎΠ»ΠΎΡΡΡΠΌΠΈ, ΠΊΠΈΡΡΠ°ΠΌΠΈ ΠΈ ΠΊΠΎΠ½ΡΠΎΠ»ΠΈΠ΄Π°ΡΠΈΠ΅ΠΉ Π² Π»Π΅Π³ΠΊΠΈΡ
Π½Π΅Π²ΡΡΡΠ½Π΅Π½Π½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ; 4) Ρ ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ, ΡΠ·Π΅Π»ΠΊΠ°ΠΌΠΈ, ΠΎΡΡΠΌΠΊΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΡΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡΠΌΠΈ; 5) Ρ ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ°ΡΡΠ°ΠΌΠΈ, ΡΠ·Π΅Π»ΠΊΠ°ΠΌΠΈ, ΠΎΡΡΠΌΠΊΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΡΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡΠΌΠΈ, ΠΏΠΎΠ΄ΠΎΠ·ΡΠ΅Π½ΠΈΠ΅ΠΌ Π½Π° Π²Π½Π΅Π»Π΅Π³ΠΎΡΠ½ΡΠΉ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π· ΠΈ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π· ΠΏΠΎΠ·Π²ΠΎΠ½ΠΎΡΠ½ΠΈΠΊΠ° Ρ ΠΏΡΠ΅-, ΠΏΠ°ΡΠ°Π²Π΅ΡΡΠ΅Π±ΡΠ°Π»ΡΠ½ΡΠΌ Π°Π±ΡΡΠ΅ΡΡΠΎΠΌ. ΠΠ°Π½Π½ΡΠ΅ ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ΅, ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΈΠ΅ ΡΠ½ΠΈΠΌΠΊΠΈ, ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΡΠ΅ΡΡ Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΈΠ· ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ, ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΡ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ±ΠΎΡΠΊΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 108 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Ρ Ρ 85 (78,70 %), Π½Π΅ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ β Ρ 23 (21,29 %) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π£ 78,82 % ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π²ΡΡΠ²Π»Π΅Π½ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Ρ 85,07 % ΠΈΠ· Π½ΠΈΡ
β Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ, Ρ 14,92 % β ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ Π²ΡΡΡΠ΅ΡΠ°Π»Π°ΡΡ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌ Π½Π΅ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ ΡΠ²Π»ΡΠ»ΡΡ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·. ΠΠΈΠΎΠΏΡΠΈΡ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΠ’ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π±Π΅Π· ΠΊΠ°ΠΊΠΈΡ
-Π»ΠΈΠ±ΠΎ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π² 61,11 % ΡΠ»ΡΡΠ°Π΅Π². ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠ΅ΠΌ (27,77 %) Π±ΡΠ» ΠΏΠ½Π΅Π²ΠΌΠΎΡΠΎΡΠ°ΠΊΡ. ΠΠΈΠΎΠΏΡΠΈΡ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΠ’ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ· Π² 98,14 % ΡΠ»ΡΡΠ°Π΅Π².ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π§ΡΠ΅ΡΠΊΠΎΠΆΠ½Π°Ρ Π±ΠΈΠΎΠΏΡΠΈΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ ΠΠ’ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ, Π²ΡΡΠΎΠΊΠΎΡΠΎΡΠ½ΡΠΌ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠ°Π½ΠΈ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ
, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΏΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
ΠΈ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π΅
Idiopathic lymphocytic interstitial pneumonia
Lymphocytic interstitial pneumonia (LIP) is one of the rare interstitial lung diseases exhibiting a profuse infiltration of lymphoid cells in the interstitium of the lung. It has been classified as one of the rare idiopathic interstitial pneumonias (IIPs) as per the recent American Thoracic Society/European Respiratory Society classification of IIPs. It is an uncommon entity in itself with the idiopathic variety being prodigiously singular. Diagnosis is accomplished by collaboration of clinicoradiological and histopathological attributes. Corticosteroids form the mainstay of therapy with a protean response to therapy. We hereby report a distinctive case of idiopathic LIP picked up inadvertently during a preoperative evaluation
KlippelβFeil syndrome with inherited coagulopathy: A rare case report
KlippelβFeil syndrome is a rare disease known to be associated with many musculoskeletal as well as somatic diseases. Thromboembolism is one of the complications, which although rarely described earlier with this syndrome, can be life-threatening. Earlier case reports have attributed it to structural abnormalities seen in this syndrome. We, however, report a rare instance of inherited coagulopathy seen with KlippelβFeil syndrome, leading to pulmonary thromboembolism
Allergic bronchopulmonary aspergillosis masquerading as malignancy in a nonasthmatic: A rare case report
Allergic bronchopulmonary aspergillosis (ABPA) is a lung disease caused by hypersensitivity reaction to antigens of Aspergillus species of which Aspergillus fumigatus is the most common culprit. ABPA is most commonly diagnosed in patients with a history of uncontrolled bronchial asthma despite optimum treatment. ABPA is rarely diagnosed in nonasthmatics. Diverse radiological appearances are known in ABPA patients; however, whole lung collapse has been rarely reported. We report a case of ABPA in a 62-year-old female with no background history of asthma, initially suspected to have bronchogenic carcinoma of the right lung. After ruling out malignancy, the diagnosis of ABPA was established based on Rosenberg-Patterson criteria. Treatment with oral steroids for 6 months in tapering doses lead to clinical and radiological improvement and decrease in IgE levels. This case is unique as ABPA masquerading as malignancy causing a lung collapse in a nonasthmatic is a very rare presentation
Treatment outcomes of drug-resistant pulmonary tuberculosis under programmatic management of multidrug-resistant tuberculosis, at tertiary care center in Mumbai
Background: This study was undertaken to analyze the clinical profile and treatment outcome in pulmonary drug-resistant tuberculosis (TB) patients under programmatic management of multidrug-resistant tuberculosis (PMDT) at a tertiary care center in Mumbai. Methodology: A retrospective study was conducted at PMDT site of a tertiary care hospital. The data of 194 pulmonary multidrug-resistant (MDR) TB patients diagnosed at our hospital or prediagnosed patients referred to our hospital were meticulously reviewed to study demography, baseline drug susceptibility to first- and second-line drugs, treatment outcomes, comorbidities, and adverse drug reactions (ADRs). Results: Out of 194 patients, 48.4% (68 cured + 26 treatment completed) were successfully treated, 22 (11.3%) failed on therapy, 39 (20.15%) patients died, 23 (11.8%) defaulted, 26 (13.4%) completed treatment with outcomes unknown, 13 (6.7%) were transferred out and in 3 patients (1.5%) treatment was stopped due to ADRs. Most common ADRs were gastrointestinal 32 (16.4%) and psychiatric 37 (19%). However, there was no statistical significance between the prevalence of ADRs and unfavorable outcomes. Most common comorbidities were GERD 27 (40.2%) and diabetes mellitus 22 (32.8%). Conclusion: Baseline drug susceptibility testing (DST) with rapid diagnostic tests, performing DST for second-line drugs, i.e., fluoroquinolones and aminoglycoside and modification of treatment regimen based on the same at start of MDR treatment has prime importance. Early detection of ADR's and comorbidities and their prompt treatment are also equally important