12 research outputs found
Evaluation of dietary pattern stability and physical activity in three consecutive generations of women
The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran
A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis
Optimizing a two-level closed-loop supply chain under the vendor managed inventory contract and learning: Fibonacci, GA, IWO, MFO algorithms
Recipient factors in faecal microbiota transplantation: one stool does not fit all
International audienceFaecal microbiota transplantation (FMT) is a promising therapy for chronic diseases associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile infections. However, in complex diseases, such as inflammatory bowel disease, irritable bowel syndrome and metabolic syndrome, its efficacy remains variable. It is accepted that donor selection and sample administration are key determinants of FMT success, yet little is known about the recipient factors that affect it. In this Perspective, we discuss the effects of recipient parameters, such as genetics, immunity, microbiota and lifestyle, on donor microbiota engraftment and clinical efficacy. Emerging evidence supports the possibility that controlling inflammation in the recipient intestine might facilitate engraftment by reducing host immune system pressure on the newly transferred microbiota. Deciphering FMT engraftment rules and developing novel therapeutic strategies are priorities to alleviate the burden of chronic diseases associated with an altered gut microbiota such as inflammatory bowel disease