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: The aim of the study was to investigate the influences of supplementation of dietary inclusion of Anti Toxic Nutrient (ATN) to the normal concentrate feed and to study the production and reproduction performances of pig maintained at institute farm of ICAR-National Research Centre on Pig, Rani, Guwahati, Assam by supplementing the Anti Toxic Nutrient (ATN) @ 0.3% in their normal feed. The animals were maintained in the standard management conditions with regard to breeding, feeding, housing and health care. The aim of the study is to find out the survivability, body weight gain, growth rate and age at puberty of Crossbred (Crosses between Hampshire and Ghungroo), Duroc and Hampshire piglets under the hot and humid climatic condition of Assam. The ATN was provided from 17-A, Chinar Drive, DLF Farms, Chattarpur, New Delhi-110074, India. The Least Square analysis of variance revealed highly significant (P<0.01) effect of body weight gain from 16th week to 21st week of the experiment and significant effect from 1st week to 3rd week and then 11th week to 15th week of experiment between ATN treated and control group. The feed conversion ratio and average daily gain also shows the highly significant effect (P< 0.01)Not Availabl

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AICRP on pig was launched during IVth five year plan (1970-1971) with the main objective of studying the performance of purebred exotic pigs under existing managemental conditions at the following research centers: I. ANGRAU, Tirupati, Andhra Pradesh II. AAU, Guwahati, Assam III. JNKVV, Jabalpur, Madhya Pradesh IV. IVRI, Izatnagar, Uttar Pradesh In 1992-93, two more centres at Kattupakam (Tamilnadu) and Mannuthy (Kerala) was added in the AICRP network. During the year 2000-2001, two more centres at ICAR Research Complex, Goa and BAU, Ranchi were started to study the performance of indigenous pig for two generations followed by their crossbreeding with Large White Yorkshire boars.AICRP on pig was launched during IVth five year plan (1970-1971) with the main objective of studying the performance of purebred exotic pigs under existing managemental conditions at the following research centers: I. ANGRAU, Tirupati, Andhra Pradesh II. AAU, Guwahati, Assam III. JNKVV, Jabalpur, Madhya Pradesh IV. IVRI, Izatnagar, Uttar Pradesh In 1992-93, two more centres at Kattupakam (Tamilnadu) and Mannuthy (Kerala) was added in the AICRP networkNot Availabl

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Not AvailableThe growth performance and nutrient digestibility on rice polish based feeding regime with and withoutphytase was studied in crossbred (Hampshire × Ghunghroo) pigs. The trial was conducted in two phases. Inphase-I (Grower stage), four iso-nitrogenous (CP18%) diets were prepared by incorporating rice polish at 25and 50% supplemented with phytase @ 20 and 40g/100 kg feed, respectively. The same animals were used insecond phase for finisher trial. In phase II, animals were fed on four iso-nitrogenous (CP16%) diets prepared byincorporation of rice polish at 50 and 70% supplemented with phytase @ 20 and 40g/100kg feed, respectively.Growth was significantly higher (P<0.05) in pigs of grower phase which was fed on rice polish at 50% levelhaving phytase enzyme (40g/100kg feed) with better feed conversion ratio (FCR) and lowest (P<0.01) feedingcost of Rs 49.33±1.48 per kg gain in comparison to other three groups. Digestibility of DM, CP, P and energyvalues increased significantly (P<0.05) by increasing rice polish from 25 to 50% in diet. However, the levels ofinclusion of rice polish with different doses of phytase supplementation in finisher pigs during phase-II did notexhibit any significant effect on ADG, FCR and feeding cost in finisher pigs. The highest average daily gain(ADG) with better FCR and lower (P<0.05) feeding cost per kg gain was recorded in pigs fed on rice polish at50% level with 20g phytase/100 kg. Digestibility of protein decreased (P<0.05) significantly with increasing ricepolish from 50 to 70% in diet irrespective of phytase level. On the other hand, digestible energy valuesincreased (P<0.05) significantly by increasing the rice polish from 50 to 70% in diet. Hence, at maximum of 40gphytase (two lac unit/100kg feed) and 20g phytase (one lac unit/100kg feed) was sufficient for better growthperformance of crossbred grower and finisher pigs, respectively fed diets containing 50% rice polishNot Availabl

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Not AvailableEighteen crossbred (HS x Ghungroo) grower pigs (about 2 months age, weighing from 5.95±0.33 to 6.03±0.53 kg) were divided into three groups of six each in a randomized block design. The pigs were fed on three different experimental diets by replacing maize with bakery waste at 0, 25 and 50% in T1, T2 and T3 groups, respectively. The pigs were fed on the experimental grower rations twice daily. The average dry matter intake (g/d) was ranged from 635.0 in T1 to 690.5 in T3, respectively and same was increased (P0.05) across the treatments, while digestibility of CP and EE were higher with both the bakery waste containing diets T2 and T3 when compared to T1. The digestibility of crude fiber decreased significantly (P0.05) by Rs. 3.71 and Rs.6.25 in T2 and T3 groups, respectively in comparison to T1 group. It is concluded that maize can be replaced up to 50% with bakery waste for formulation of economic ration without affecting the growth, FCR and feed cost per kg gain in crossbred pigsNot Availabl

Development of a Scalable Synthesis of a Bruton’s Tyrosine Kinase Inhibitor via C–N and C–C Bond Couplings as an End Game Strategy

A scalable and convergent synthesis of a BTK (Bruton’s tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, which was prepared <i>via</i> a regioselective cyclization of an isocyanate, mediated by AlCl₃. Improved routes to key building blocks were demonstrated by expedient multikilogram productions. The target compound was assembled through a Pd-catalyzed amidation reaction followed by a Suzuki–Miyaura cross-coupling reaction

Development of a Scalable Synthesis of a Bruton’s Tyrosine Kinase Inhibitor via C–N and C–C Bond Couplings as an End Game Strategy

A scalable and convergent synthesis of a BTK (Bruton’s tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, which was prepared <i>via</i> a regioselective cyclization of an isocyanate, mediated by AlCl₃. Improved routes to key building blocks were demonstrated by expedient multikilogram productions. The target compound was assembled through a Pd-catalyzed amidation reaction followed by a Suzuki–Miyaura cross-coupling reaction