Common principles for optimization of the athletes’ acclimatization to hot and humid climate

Objective: to develop an adaptation control technology to the hot climate for elite athletes. Materials and methods: data analysis, summarizing the experience of adaptation and acclimatization measures in preparation of national teams of Russia for the major international competitions; development and testing of integrated technologies for acceleration and optimization of the athletes’ body state in the light of specific features of the sport in a hot and humid climate. Results: materials about preparation of teams of the USSR and Russia for the largest international competition in hot and humid climates were analyzed. ^e plan of implementation of an integrated management technology for adaptation of athletes was developed at the stage of immediate preparation for major competitions and included activities in three areas: organizational, scientific-methodical and educational. Methodological recommendations were developed including monitoring of the athletes’ status and prevention of disorders of the major organs and systems. Conclusions: an acclimatization training camp should be advantageously carried out in an intermediate geographic area, similar in time zone, climatic and geographic characteristics of the competition place. The sport team should be moved to the competition place within two or three days before the championship’s beginning. It is important to monitor hydration status, electrolyte balance and levels of key hormones in the process of adaptation

Экспрессия муцинов при раке печени

Increasing incidence, difficulties in early diagnosis, and a high mortality rate in liver cancer (LC) determine the relevance of studying the mechanisms of its development. The aim of the work is to evaluate the expression of high molecular weight glycoproteins MUC-1, MUC-13 in liver cancer. The object of study is LC tissue samples of 65 patients from the archives and 34 blood serum samples from patients with morphologically confirmed LC. The age of subjects was 26– 97 years. The level of antibodies to MUC-1 and MUC-13 was studied by ELISA. The reference value ranges of MUC-1 (0.250 ± 0.10 ng/ml) and MUC-13 (0.321 ± 0.13 ng/ml) in the blood serum of healthy individuals were established. The concentration of antibodies to MUC-1 and MUC-13 in the blood serum in RP was significantly higher than that in practically healthy individuals. The concentration of MUC-1 and MUC-13 in the LC tumor tissue was higher than that in the blood serum of apparently healthy individuals and LC patients. With a confirmed LC diagnosis, the level of antibodies to MUC-1 in the blood serum, which exceeds 0.373 ng/ml, and the level of antibodies to MUC-13, which is more than 0.939 ng/ml, may indicate a high risk of a tumor process.Рост заболеваемости, трудности ранней диагностики и высокий уровень летальности пациентов при раке печени (РП) определяют актуальность изучения механизмов его развития. Оценена экспрессия высокомолекулярных гликопротеинов MUC-1, MUC-13 при РП. Предметом исследования были 65 архивных образцов тканей опухоли печени и 34 пробы сыворотки крови у пациентов с морфологически подтвержденным РП. Возраст обследуемых составил 26–97 лет. Исследование уровня антител к MUC-1 и MUC-13 проводили методом ИФА. Установлены пределы референтных значений MUC-1 (0,250 ± 0,10 нг/мл) и MUC-13 (0,321 ± 0,13 нг/мл) в сыворотке крови у здоровых лиц. Концентрация сывороточных антител к MUC-1 и MUC-13 у пациентов с РП была значимо выше показателей здоровых лиц. Содержание MUC-1 и MUC-13 в ткани опухоли печени было более высоким, чем в сыворотке крови практически здоровых лиц и пациентов с РП. При подтвержденном диагнозе РП уровень антител к MUC-1, превышающий в сыворотке крови 0,373 нг/мл, и уровень антител к MUC-13 более 0,939 нг/мл может указывать на высокий риск наличия опухолевого процесса

A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area

Tn this work we focus on a microsatellite-defined Y-chromosomal lineage (network 1.2) identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers. Here, we set network 1.2 in the Y-chromosomal phylogenetic tree, date it with respect to other lineages associated with the same movements by other authors, examine its diversity by means of tri- and tetranucleotide loci and discuss the implications hi reconstructing the spread of this group of chromosomes in the Mediterranean area. Our results define a tripartite phylogeny wit-bin HG 9 (Rosser et al. 2000) with the deepest branching defined by alleles T (Haplogroup Eu 10) or G (Haplogroup Eu9) at M172 (Semino et al. 2000), and a subsequent branching within Eu9 defined by network 1.2. Population distributions of HG 9 and network 1.2 show that their occurrence in the surveyed area is not due to the spread of people from a single parental population but, rather, to a process punctuated by at least two phases. Our data identify the wide area of the Balkans, Aegean and Anatolia as the possible homeland harbouring the largest variation within network 1.2. The use of recently proposed tests based on the stepwise mutation model suggests that its spread was associated to a population expansion, xvith a high rate of male gene flow in the Turkish Greek area

ДИЭЛЕКТРИЧЕСКИЕ ХАРАКТЕРИСТИКИ МОНОКРИСТАЛЛОВ TlGaS2, ДОПИРОВАННЫХ Со и Yb

Electrical conductivity and dielectric properties of TlGaS2, TlGa0,999Yb0,001S2 and TlGa0,99 Co0,01S2  single crystals are investigated in the temperature range 150–320 K at the measuring field frequencies of 103 –106 Hz. The values of generalized activation energy of charge carriers in these crystals are determined. It is shown that the absolute values of the characteristics studied increase with temperature. The temperature dependences of the dielectric constant of these crystals have revealed the anomalies in the form of wide peaks, indicating the presence of their structural changes at temperatures ~ 170–250 K. The dispersion of the dielectric properties of the single crystals under study is seen: with a frequency growth the dielectric constant values decrease, and electrical conductivity values increase. It is found that the cobalt and ytterbium doping of TlGaS2 crystals decrease permittivity values and increase electrical conductivity values.Проведены исследования электропроводности и диэлектрических характеристик монокристаллов TlGaS2, TlGa0,999Yb0,001S2 и TlGa0,99 Co0,01S2 в интервале температур 150–320 К на частотах измерительного поля 103 –106 Гц. Определены значения обобщенной энергии активации основных носителей заряда в этих кристаллах. Показано, что абсолютные значения изученных характеристик возрастают при увеличении температуры. На кривых температурной зависимости диэлектрической проницаемости исследуемых кристаллов обнаружены аномалии в виде широких максимумов, свидетельствующие о наличии структурных превращений в них в области температур ~ 170–250 К. Выявлена дисперсия диэлектрических свойств исследованных монокристаллов: с ростом частоты значения диэлектрической проницаемости уменьшаются, а удельной электропроводности – увеличиваются. Показано, что легирование кристаллов TlGaS2 кобальтом и иттербием приводит к уменьшению значений диэлектрической проницаемости и увеличению значений электропроводности

Modern approach to complex treatment of diabetic foot syndrome in a surgical hospital

139 patients exposed to surgical interventions concerning the diabetic foot syndrome (DFS) from 2013 to 2015 were analyzed in this article. They were divided in two groups: patients with neuropathic (n=60) and neuroischemic (n=79) types of DFS. The dependence of surgical treatment results from the prevalence of purulent-necrotic processes was evaluated. The tendency of decrease of major amputations was established.В статье проанализированы 139 пациентов, которым выполнены хирургические вмешательства по поводу синдрома диабетической стопы (СДС) в период с 2013-го по 2015 год. Выделены 2 группы: пациенты с нейропатическим (n=60) и нейроишемическим (n=79) типами СДС. В ходе работы была оценена зависимость исходов операций от распространенности гнойно-некротических процессов, а также была установлена тенденция к уменьшению количества больших ампутаций

Electronic properties and phase transitions in low-dimensional semiconductors

We present the first review of the current state of the literature on electronic properties and phase transitions in TlX and TlMX2 (M = Ga, In; X = Se, S, Te) compounds. These chalcogenides belong to a family of the low-dimensional semiconductors possessing chain or layered structure. They are of significant interest because of their highly anisotropic properties, semi- and photoconductivity, non-linear effects in their I-V characteristics (including a region of negative differential resistance), switching and memory effects, second harmonic optical generation, relaxor behavior and potential applications for optoelectronic devices. We review the crystal structure of TlX and TlMX2 compounds, their transport properties under ambient conditions, experimental and theoretical studies of the electronic structure, transport properties and semiconductor-metal phase transitions under high pressure, and sequences of temperature-induced structural phase transitions with intermediate incommensurate states. Electronic nature of the ferroelectric phase transitions in the above-mentioned compounds, as well as relaxor behavior, nanodomains and possible occurrence of quantum dots in doped and irradiated crystals is discussed.Comment: 70 pages, 38 figure

Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period

Mucin expression in liver tumors

Difficulties in diagnosis, the prevalence of oncological processes, their medical, social and economic significance and high mortality rate determine the relevance of the fight against them and make the problem of studying the mechanisms of their early diagnosis one of the key ones. The subject of research now is the description of many biological markers, the determination of which allows us to assess the risks of developing a disease, diagnose a tumor, and serve as a biological indicator of the tumor process. The subjects of the study were tissue samples from 65 patients with liver cancer. The level of antibodies to MUC-1 and MUC-13 was studied. The established value of the concentration of antibodies to MUC-1 and MUC-13 in the blood serum of people with liver cancer is higher than the values in practically healthy individuals (p = 0.002; p = 0.0001), and the concentration of antibodies to MUC-1 and MUC-13 in the tissue tumors of cancer patients is higher than in the blood serum of healthy individuals and patients with liver cancer (p<0.05). The expression level of MUC-1 and MUC-13 in the tumor tissue is not related to the age and sex of patients