Efficacy and Tolerability of Fixed-Dose Combination of Dexketoprofen and Dicyclomine Injection in Acute Renal Colic

Objective. To evaluate the efficacy and tolerability of a fixed-dose combination of dexketoprofen and dicyclomine (DXD) injection in patients with acute renal colic. Patients and Methods. Two hundred and seventeen patients were randomized to receive either DXD (n = 109) or fixed-dose combination of diclofenac and dicyclomine injection (DLD; n = 108), intramuscularly. Pain intensity (PI) was self-evaluated by patients on visual analogue scale (VAS) at baseline and at 1, 2, 4, 6, and 8 hours. Efficacy parameters were proportion of responders, difference in PI (PID) at 8 hours, and sum of analogue of pain intensity differences (SAPID). Tolerability was assessed by patients and physicians. Results. DXD showed superior efficacy in terms of proportion of responders (98.17% versus 81.48; P < 0.0001), PID at 8 hours (P = 0.002), and SAPID0–8 hours (P = 0.004). The clinical global impression for change in pain was significantly better for DXD than DLD. The incidence of adverse events was comparable in both groups. However, global assessment of tolerability was rated significantly better for DXD. Conclusion. DXD showed superior efficacy and tolerability than DLD in patients clinically diagnosed to be suffering from acute renal colic

Corrosion tests of various alloys in fluorides of lithium, sodium and potassium (FLiNaK) medium for molten salt reactors in the temperature range of 550-750ºC using electrochemical techniques

84-88Hydrogen (H2) is an alternative to petroleum based environment polluting transport fuel. High temperature process heat in the range of 500-1000°C is needed for (H2) production by water splitting. This heat can be generated in molten salt nuclear reactors. Compatibility of materials is a bottle neck problem in this process. Corrosion behaviours of different alloys have been evaluated in fluoride eutectic FLiNaK in the temperature range of 550-750°C under static and dynamic conditions. Electrochemical polarization and impedance techniques have been used to estimate corrosion rate. The results show that the corrosion process is controlled by activation and in some cases by formation of passive layer. In static mode, the corrosion rates followed the order: Inconel 625 > Inconel 617 > Inconel 600 > Incoloy 800 > Ni 220 > Hastelloy N > Incoloy 800 HT. In dynamic mode, Haselloy N and Incoloy 800 show better corrosion resistance in comparison to other alloys

Corrosion tests of various alloys in fluorides of lithium, sodium and potassium (FLiNaK) medium for molten salt reactors in the temperature range of 550-750ºC using electrochemical techniques

Hydrogen (H2) is an alternative to petroleum based environment polluting transport fuel. High temperature process heat in the range of 500-1000°C is needed for (H2) production by water splitting. This heat can be generated in molten salt nuclear reactors. Compatibility of materials is a bottle neck problem in this process. Corrosion behaviours of different alloys have been evaluated in fluoride eutectic FLiNaK in the temperature range of 550-750°C under static and dynamic conditions. Electrochemical polarization and impedance techniques have been used to estimate corrosion rate. The results show that the corrosion process is controlled by activation and in some cases by formation of passive layer. In static mode, the corrosion rates followed the order: Inconel 625 &gt; Inconel 617 &gt; Inconel 600 &gt; Incoloy 800 &gt; Ni 220 &gt; Hastelloy N &gt; Incoloy 800 HT. In dynamic mode, Haselloy N and Incoloy 800 show better corrosion resistance in comparison to other alloys