Rapid prototyping and validation of FS-FBMC dynamic spectrum radio with simulink and ZynqSDR

This paper presents the research carried out in developing and targeting a novel real-time Dynamic Spectrum Access (DSA) Frequency Spread Filter Bank Multicarrier (FS-FBMC) transmitter prototype to programmable ‘ZynqSDR’ Software Defined Radio (SDR) hardware, and introduces a series of experiments used to validate the design’s ‘cognitive’ DSA capabilities. This transmitter is a proof of concept, that uses DSA techniques to enable Secondary Users (SUs) to access the band traditionally used for FM Radio broadcasting (88-108 MHz), and establish data communication channels in vacant parts of the FM Radio Primary User (PU) spectrum using a multicarrier modulation scheme with a Non Contiguous (NC) channel mask. Once implemented on the hardware, the transmitter is subjected to various FM Radio environments sampled from around Central Scotland, and it is demonstrated that it can dynamically adapt its NC transmitter mask in real time to protect the FM Radio signals it detects. A video is presented of this dynamic on-hardware spectral reconfiguration, and the reader is encouraged to view the video to appreciate the responsiveness of the design. An investigation into potential FBMC guardband sizes is carried out, with initial findings indicating a guardband of 200 kHz (either side of an FM Radio station) is required in order to prevent interference with the PUs. This paper also demonstrates the capabilities of the MATLAB®/ Simulink ZynqSDR workflow, and provides a case study and reference design that we feel other researchers working in this field can benefit from

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer

Abstract OBJECTIVE: Patients with cancer have antibodies against tumour antigens. Characterising the antibody repertoire may provide insights into aberrant cellular mechanisms in cancer development, ultimately leading to novel diagnostic or therapeutic targets. The aim of this study was to characterise the antibody profiles in patients whose symptoms warranted colonoscopy, to see if there was a difference in patients with and without colorectal cancer. METHODS: Patients were recruited from a colonoscopy clinic. Individual serum samples from 43 patients with colorectal cancer and 40 patients with no cancer on colonoscopy were profiled on a 37 830 clone recombinant human protein array. Antigen expression was evaluated by quantitative reverse transcription-PCR and by immunohistochemistry on tissue microarrays. RESULTS: Using a sex- and age-matched training set, 18 antigens associated with cancer and 4 associated with the absence of cancer (p\u3c0.05) were identified and confirmed. To investigate the mechanisms triggering antibody responses to these antigens, antigen expression was examined in normal colorectal mucosa and colorectal carcinoma of the same patients. The identified antigens showed cellular accumulation (p53), aberrant cellular expression (high mobility group B1 (HMGB1)) and overexpression (tripartite motif-containing 28 (TRIM28), p53, HMGB1, transcription factor 3 (TCF3), longevity assurance gene homologue 5 (LASS5) and zinc finger protein 346 (ZNF346)) in colorectal cancer tissue compared with normal colorectal mucosa. CONCLUSIONS: It is demonstrated for the first time that screening high-density protein arrays identifies unique antibody profiles that discriminate between symptomatic patients with and without colorectal cancer. The differential expression of identified antigens suggests their involvement in aberrant cellular mechanisms in cance

Measurement of the hadronic activity in events with a Z and two jets and extraction of the cross section for the electroweak production of a Z with two jets in pp collisions at s√=7 TeV

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2FJHEP10%282013%29062.The first measurement of the electroweak production cross section of a Z boson with two jets (Zjj) in pp collisions at s√=7 TeV is presented, based on a data sample recorded by the CMS experiment at the LHC with an integrated luminosity of 5 fb(−1). The cross section is measured for the ℓℓjj (ℓ = e, μ) final state in the kinematic region m(ℓℓ) > 50 GeV, m(jj) > 120 GeV, transverse momenta p(j)(T)>25 GeV and pseudorapidity |η(j)| < 4.0. The measurement, combining the muon and electron channels, yields σ = 154 ± 24 (stat.) ± 46 (exp. syst.) ± 27 (th. syst.) ± 3 (lum.) fb, in agreement with the theoretical cross section. The hadronic activity, in the rapidity interval between the jets, is also measured. These results establish an important foundation for the more general study of vector boson fusion processes, of relevance for Higgs boson searches and for measurements of electroweak gauge couplings and vector boson scattering

Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men

We recently reported that the nonselective cyclooxygenase (COX) inhibitor ketorolac attenuated sweating but not cutaneous vasodilation during moderate‐intensity exercise in the heat. However, the specific contributions of COX‐1 and COX‐2 to the sweating response remained to be determined. We tested the hypothesis that COX‐1 but not COX‐2 contributes to sweating with no role for either COX isoform in cutaneous vasodilation during moderate‐intensity exercise in the heat. In thirteen young males (22 ± 2 years), sweat rate and cutaneous vascular conductance were measured at three forearm skin sites that were continuously treated with (1) lactated Ringer\u27s solution (Control), (2) 150 μmmol·L−1 celecoxib, a selective COX‐2 inhibitor, or (3) 10 mmol L−1 ketorolac, a nonselective COX inhibitor. Participants first rested in a non heat stress condition (≥85 min, 25°C) followed by a further 70‐min rest period in the heat (35°C). They then performed 50 min of moderate‐intensity cycling (~55% peak oxygen uptake) followed by a 30‐min recovery period. At the end of exercise, sweat rate was lower at the 150 μmol·L−1 celecoxib (1.51 ± 0.25 mg·min−1·cm−2) and 10 mmol·L−1 ketorolac (1.30 ± 0.30 mg·min−1·cm−2) treated skin sites relative to the Control site (1.89 ± 0.27 mg·min−1·cm−2) (both P ≤ 0.05). Additionally, sweat rate at the ketorolac site was attenuated relative to the celecoxib site (P ≤ 0.05). Neither celecoxib nor ketorolac influenced cutaneous vascular conductance throughout the experiment (both P > 0.05). We showed that both COX‐1 and COX‐2 contribute to sweating but not cutaneous vasodilation during moderate‐intensity exercise in the heat in young men

Measurement of the Λ(0)(b) lifetime in pp collisions at s√=7 TeV

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2FJHEP07%282013%29163.A measurement of the Λ(0)(b) lifetime using the decay Λ(0)(b)→J/ψΛ in protonproton collisions at s√=7 TeV is presented. The data set, corresponding to an integrated luminosity of about 5 fb(−1), was recorded with the CMS experiment at the Large Hadron Collider using triggers that selected dimuon events in the J/ψ mass region. The Λ(0)(b) lifetime is measured to be 1.503 ± 0.052 (stat.) ± 0.031 (syst.) ps

Search for new physics in events with same-sign dileptons and b jets in pp collisions at s√=8 TeV

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2FJHEP03%282013%29037.A search for new physics is performed using events with isolated same-sign leptons and at least two bottom-quark jets in the final state. Results are based on a sample of proton-proton collisions collected at a center-of-mass energy of 8 TeV with the CMS detector and corresponding to an integrated luminosity of 10.5 fb(−1). No excess above the standard model background is observed. Upper limits are set on the number of events from non-standard-model sources and are used to constrain a number of new physics models. Information on acceptance and efficiencies is also provided so that the results can be used to confront an even broader class of new physics models

Measurement of the production cross section for Zγ→ν(ν-bar)γ in pp collisions at s√=7 TeV and limits on ZZγ and Zγγ triple gauge boson couplings

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2FJHEP10%282013%29164.A measurement of the Zγ→ν(ν-bar)γ cross section in pp collisions at s√=7 TeV is presented, using data corresponding to an integrated luminosity of 5.0 fb(−1) collected with the CMS detector. This measurement is based on the observation of events with an imbalance of transverse energy in excess of 130 GeV and a single photon in the absolute pseudorapidity range |η| < 1.4 with transverse energy above 145 GeV. The Zγ→ν(ν-bar)γ production cross section is measured to be 21.1 ± 4.2 (stat.) ± 4.3 (syst.) ± 0.5 (lum.) fb, which agrees with the standard model prediction of 21.9 ± 1.1 fb. The results are combined with the CMS measurement of Zγ production in the ℓ (+) ℓ (−) γ final state (where ℓ is an electron or a muon) to yield the most stringent limits to date on triple gauge boson couplings: ∣∣h(Z)(3)∣∣<2.7×10(−3) , ∣∣h(Z)(4)∣∣<1.3×10(−5) for ZZγ and ∣∣h(γ)(3)∣∣<2.9×10(−3) , ∣∣h(γ)(4)∣∣<1.5×10(−5) for Zγγ couplings

Measurement of the W-boson helicity in top-quark decays from tt-bar production in lepton+jets events in pp collisions at s√=7 TeV

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2FJHEP10%282013%29167.The W-boson helicity fractions in top-quark decays are measured with tt-bar events in the lepton+jets final state, using proton-proton collisions at a centre-of-mass energy of 7 TeV, collected in 2011 with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 5.0 fb(−1). The measured fractions of longitudinal, left-, and right-handed helicity are F 0 = 0.682 ± 0.030 (stat.) ± 0.033 (syst.), F L = 0.310 ± 0.022 (stat.) ± 0.022 (syst.), and F R = 0.008 ± 0.012 (stat.) ± 0.014 (syst.), consistent with the standard model predictions. The measured fractions are used to probe the existence of anomalous Wtb couplings. Exclusion limits on the real components of the anomalous couplings g L , g R are also derived

Search for pair-produced dijet resonances in four-jet final states in pp collisions at s√=7 TeV

This is the publisher's version, also available electronically from http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.110.141802.A search for the pair production of a heavy, narrow resonance decaying into two jets has been performed using events collected in s√=7  TeV pp collisions with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 5.0  fb(−1). Events are selected with at least four jets and two dijet combinations with similar dijet mass. No resonances are found in the dijet mass spectrum. The upper limit at 95% confidence level on the product of the resonance pair production cross section, the branching fractions into dijets, and the acceptance varies from 0.22 to 0.005 pb, for resonance masses between 250 and 1200 GeV. Pair-produced colorons decaying into qq-bar are excluded for coloron masses between 250 and 740 GeV

Search for supersymmetry in final states with a single lepton, b-quark jets, and missing transverse energy in proton-proton collisions at s√=7 TeV

This is the publisher's version, also available electronically from http://journals.aps.org/prd/abstract/10.1103/PhysRevD.87.052006.A search motivated by supersymmetric models with light top squarks is presented using proton-proton collision data recorded with the CMS detector at a center-of-mass energy of s√=7  TeV during 2011, corresponding to an integrated luminosity of 4.98  fb(−1). The analysis is based on final states with a single lepton, b-quark jets, and missing transverse energy. Standard model yields are predicted from data using two different approaches. The observed event numbers are found to be compatible with these predictions. Results are interpreted in the context of the constrained minimal supersymmetric standard model and of a simplified model with four top quarks in the final state