The Lantern Vol. 7, No. 1, December 1938

• The Greatest Gift of All • Peace • Two Bums • October Paints the Valleys • Have the Notes Died? • America\u27s Defeatism Complex • Tahiti Jacques • When We Take Heed of Life • From The Sky Image • Still Moments • Noel • Foreign Hills • Just Beforehttps://digitalcommons.ursinus.edu/lantern/1012/thumbnail.jp

The Lantern Vol. 6, No. 3, June 1938

• Editorial • A Senior Muses • Affinity • From Darkness Into Light • Just an Old Bell! • Memories of a Friend • To a Small Animal as it Passes • The Sky and I • Between the Mountain and the River • Solace • Three Little Islands Far From Home • Beachcomberhttps://digitalcommons.ursinus.edu/lantern/1011/thumbnail.jp

The Lantern Vol. 7, No. 3, June 1939

• Commencement Sonnet • Largo Appassionato • More Sonnets to Earth • Vladimir • Abe Lincoln in Illinois • Dark Lives • Enter Mr. Smithingham II • A Character is Sketched • Sonnet • Out of the Dawn • Wistaria • Poem Without a Name • You Have Loved the Nighthttps://digitalcommons.ursinus.edu/lantern/1018/thumbnail.jp

The Lantern Vol. 6, No. 2, March 1938

• Among Our Contributors • Of Special Interest To You! • Jenny Lee • The Arguments Against Isolation • The Note • Visit of the Grandchildren • One Finds God • To The North Lies New Hampshire • The Two Camps in Washington • Substitutes • At Times It Seems So Very Strange • Episode on a Lake Shore • My Campus Song • Irony • A Chinese Mysteryhttps://digitalcommons.ursinus.edu/lantern/1017/thumbnail.jp

Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes: Findings From the NCAA and Department of Defense CARE Consortium

Importance: There is potential scientific and clinical value in validation of objective biomarkers for sport-related concussion (SRC). Objective: To investigate the association of acute-phase blood biomarker levels with SRC in collegiate athletes. Design, Setting, and Participants: This multicenter, prospective, case-control study was conducted by the National Collegiate Athletic Association (NCAA) and the US Department of Defense Concussion Assessment, Research, and Education (CARE) Consortium from February 20, 2015, to May 31, 2018, at 6 CARE Advanced Research Core sites. A total of 504 collegiate athletes with concussion, contact sport control athletes, and non-contact sport control athletes completed clinical testing and blood collection at preseason baseline, the acute postinjury period, 24 to 48 hours after injury, the point of reporting being asymptomatic, and 7 days after return to play. Data analysis was conducted from March 1 to November 30, 2019. Main Outcomes and Measures: Glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilament light chain, and tau were quantified using the Quanterix Simoa multiplex assay. Clinical outcome measures included the Sport Concussion Assessment Tool-Third Edition (SCAT-3) symptom evaluation, Standardized Assessment of Concussion, Balance Error Scoring System, and Brief Symptom Inventory 18. Results: A total of 264 athletes with concussion (mean [SD] age, 19.08 [1.24] years; 211 [79.9%] male), 138 contact sport controls (mean [SD] age, 19.03 [1.27] years; 107 [77.5%] male), and 102 non-contact sport controls (mean [SD] age, 19.39 [1.25] years; 82 [80.4%] male) were included in the study. Athletes with concussion had significant elevation in GFAP (mean difference, 0.430 pg/mL; 95% CI, 0.339-0.521 pg/mL; P < .001), UCH-L1 (mean difference, 0.449 pg/mL; 95% CI, 0.167-0.732 pg/mL; P < .001), and tau levels (mean difference, 0.221 pg/mL; 95% CI, 0.046-0.396 pg/mL; P = .004) at the acute postinjury time point compared with preseason baseline. Longitudinally, a significant interaction (group × visit) was found for GFAP (F7,1507.36 = 16.18, P < .001), UCH-L1 (F7,1153.09 = 5.71, P < .001), and tau (F7,1480.55 = 6.81, P < .001); the interaction for neurofilament light chain was not significant (F7,1506.90 = 1.33, P = .23). The area under the curve for the combination of GFAP and UCH-L1 in differentiating athletes with concussion from contact sport controls at the acute postinjury period was 0.71 (95% CI, 0.64-0.78; P < .001); the acute postinjury area under the curve for all 4 biomarkers combined was 0.72 (95% CI, 0.65-0.79; P < .001). Beyond SCAT-3 symptom score, GFAP at the acute postinjury time point was associated with the classification of athletes with concussion from contact controls (β = 12.298; 95% CI, 2.776-54.481; P = .001) and non-contact sport controls (β = 5.438; 95% CI, 1.676-17.645; P = .005). Athletes with concussion with loss of consciousness or posttraumatic amnesia had significantly higher levels of GFAP than athletes with concussion with neither loss of consciousness nor posttraumatic amnesia at the acute postinjury time point (mean difference, 0.583 pg/mL; 95% CI, 0.369-0.797 pg/mL; P < .001). Conclusions and Relevance: The results suggest that blood biomarkers can be used as research tools to inform the underlying pathophysiological mechanism of concussion and provide additional support for future studies to optimize and validate biomarkers for potential clinical use in SRC

Circadian fluctuation of plasma epinephrine in supine humans

Previous studies have demonstrated circadian fluctuations of systemic catecholamines in man. However, methodological differences and conflicting results with epinephrine are apparent. In the present study, plasma and urinary epinephrine and norepinephrine and plasma cortisol were studied in healthy young adult males over 24 hr with 20 min plasma sampling and EEG monitoring of sleep. Plasma epinephrine did not have a circadian variation in supine subjects. Urinary epinephrine levels and small urinary circadian variations were increased by normal posture and activity. Sleep and sleep stage were not associated with different plasma epinephrine levels, and no ultradian fluctuation was observed. Levels of norepinephrine and cortisol were normal. Based on all studies to date, it appears that basal plasma epinephrine has either a very small amplitude or no circadian rhythm, but that changes in posture and activity or the rest/activity cycle may modify this pattern.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26858/1/0000423.pd

The Lantern Vol. 7, No. 2, March 1939

• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp

The Lantern Vol. 7, No. 2, March 1939

• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp

The Lantern Vol. 5, No. 3, May 1937

• Dedication • Dr. McClure: An Ursinus Man • Roar, O Wind! • To the Ladies! • The Futility of Dying • The Symbolism of the British Crown • Oh! • It Might Have Been • Treat Yourself? • Three Writers • Hawaii in June • On Being a Twin • Black Magic • Triangle • Who Longs? • A Son Passes • Sing an Old-Fashioned Song • Questioning • An Argument About a Fish • That Morning Eye-Opener • Scoop for the Sun • The Dead Do Not Die Once • Give Us Timehttps://digitalcommons.ursinus.edu/lantern/1010/thumbnail.jp

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.

Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients. Identification of reliable prognostic biomarkers would enable treatment to be personalized so that patients destined to experience aggressive disease could receive appropriately potent therapies from diagnosis, while those who will experience more indolent disease are not exposed to the risks and side effects of unnecessary immunosuppression. Using transcriptional profiling of circulating T cells isolated from patients with CD and UC, we identified analogous CD8+ T cell transcriptional signatures that divided patients into 2 otherwise indistinguishable subgroups. In both UC and CD, patients in these subgroups subsequently experienced very different disease courses. A substantially higher incidence of frequently relapsing disease was experienced by those patients in the subgroup defined by elevated expression of genes involved in antigen-dependent T cell responses, including signaling initiated by both IL-7 and TCR ligation - pathways previously associated with prognosis in unrelated autoimmune diseases. No equivalent correlation was observed with CD4+ T cell gene expression. This suggests that the course of otherwise distinct autoimmune and inflammatory conditions may be influenced by common pathways and identifies what we believe to be the first biomarker that can predict prognosis in both UC and CD from diagnosis, a major step toward personalized therapy