The Ursinus Weekly, February 20, 1969

Excavation begun on lab facilities • Byerly discusses U.C. status for Phi Beta Kappa • Emig turns back Sayare challenge; Novak, Rozycka win in close V.P. contests • SFARC to conduct student drinking poll • Parking regulations • UC Arts Festival opens on March 7 • Only 125 attend winter IF dance • In memoriam • Kitchen experiment • On applied pressure • Letters to the editor • Forum review: Man-sculpture relationship born of African creations\u27 animism • Editorial: Arts weekend, March 7-9 • St. Andrews Society grants awards for study in Scotland • SFARC considers alcohol, arrangement of rules • U.C. holds bleed-in • Ursinus offers graduate course • Sirens seek Lorelei dates • Print Club sponsors campus print exhibit • Bears fall to Mules after Hopkins win • Hofmaster lone victor in Delaware mauling • Gillespie takes luncheon award • Dickinson studies alternatives to college fraternity system • Contemplationshttps://digitalcommons.ursinus.edu/weekly/1170/thumbnail.jp

The Ursinus Weekly, January 23, 1969

Williams presents Aesthetic Japan • USGA announces students named to Ursinus Board • Cut system modified for failing students • Ursinus obtains Gulf Oil grant • Merck & Co. awards research grant to UC • Final examination schedule • Confrontation: Black vs. white • Editorial: Another chapter in the ongoing inquiry in the higher morality as precepted and pursued on the Ursinus College campus • Letters to the editor • Exchange • Underground films debut at Ursinus • Editorial: Neglected issues • Faculty portrait: Dr. Levie Van Dam • Freeland spirit pervades • Parents O.K. strict rules • Bears drop three, fall to PMC, 61-60 • UC matmen down Albright squad • The President casts a vote for football • Greek gleanings • Committee deliberates on Ursinus centennial • A.C.A.C. initiates graduate services • Placement Office posts interviewshttps://digitalcommons.ursinus.edu/weekly/1169/thumbnail.jp

Assessment of the In Vivo

The objective of tailoring medicines for cancer patients according to the molecular profile of their disease holds great promise for the improvement of cancer therapy. Nevertheless, this approach has been limited, in part, due to the lack of predictive and informative preclinical studies. Herein, we describe an assessment of the therapeutic potential of targeting PI3K/mTOR and MAPK signaling in genetically defined mouse models of colorectal cancer mirroring disease subtypes targeted for novel therapy in the FOCUS4 trial. Our studies demonstrate that dual PI3K/mTOR inhibition is highly effective in invasive adenocarcinoma models characterized by combinatorial mutations in Apc and Pten; Apc and Kras; and Apc, Pten and Kras. MEK inhibition was effective in the combinatorial Apc and Kras setting, but had no impact in either Apc Pten mutants or in Apc Pten Kras triple mutants. Furthermore, we describe the importance of scheduling for combination studies and show that although no additional benefit is gained in Apc Pten mice, combination of PI3K/mTOR and MAPK inhibition leads to an additive benefit in survival in Apc Kras mice and a synergistic increase in survival in Apc Pten Kras mice. This is the first study using robust colorectal cancer genetically engineered mouse models to support the validity of PI3K/mTOR and MEK inhibitors as tailored therapies for colorectal cancer and highlight the potential importance of drug scheduling in the clinic

The Ursinus Weekly, October 31, 1968

Evaluation favorable; Provincialism assailed • Nixon overwhelms Humphrey; Rightward trend reflected • Founders\u27 Day honors alumni; Honorary degrees conferred • Secret society members elected • Placement Office offers services to \u2769 graduates • Barbara Bruzgo crowned \u2768 Homecoming Queen • Editorial: Activities chaos • Grand Dragon at U.C.; Klan views stated • Grape conspiracy • Letters to the editor • Formation of a fourth party • Editorial: Literary dilemma • Arts forum features four faculty speakers • Opinion: Sulphuric acid + gas • Bears rip Garnet in Homecoming game after humiliating defeat at Muhlenberg • Gillespie and Gane selected as co-captains • Soccer team defeated by Mules and Delaware as Grau is injured • Inside track: And Drexel makes eighteen • Bearettes and West Chester battle here next Thursday • Magicians, Homecoming and R. J. Whatley • Flowers are still undefeated as I.T.F.L. enters fourth week; Beta Sig upsets Sig Rho, 12-7 • Del Valley\u27s QB is man to watch • Hockey team destroys opponents; Cash and Landis star, score 13 • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1165/thumbnail.jp

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor

Background and Purpose Flecainide is a use-dependent blocker of cardiac Na+ channels. Mechanistic analysis of this block showed that the cationic form of flecainide enters the cytosolic vestibule of the open Na+ channel. Flecainide is also effective in the treatment of catecholaminergic polymorphic ventricular tachycardia but, in this condition, its mechanism of action is contentious. We investigated how flecainide derivatives influence Ca2+-release from the sarcoplasmic reticulum through the ryanodine receptor channel (RyR2) and whether this correlates with their effectiveness as blockers of Na+ and/or RyR2 channels. Experimental Approach We compared the ability of fully charged (QX-FL) and neutral (NU-FL) derivatives of flecainide to block individual recombinant human RyR2 channels incorporated into planar phospholipid bilayers, and their effects on the properties of Ca2+ sparks in intact adult rat cardiac myocytes. Key Results Both QX-FL and NU-FL were partial blockers of the non-physiological cytosolic to luminal flux of cations through RyR2 channels but were significantly less effective than flecainide. None of the compounds influenced the physiologically relevant luminal to cytosol cation flux through RyR2 channels. Intracellular flecainide or QX-FL, but not NU-FL, reduced Ca2+ spark frequency. Conclusions and Implications Given its inability to block physiologically relevant cation flux through RyR2 channels, and its lack of efficacy in blocking the cytosolic-to-luminal current, the effect of QX-FL on Ca2+ sparks is likely, by analogy with flecainide, to result from Na+ channel block. Our data reveal important differences in the interaction of flecainide with sites in the cytosolic vestibules of Na+ and RyR2 channels

The Ursinus Weekly, October 10, 1969

Seven join, six leave Ursinus faculty • UC and 500 colleges schedule Vietnam moratorium Wednesday; Classes not officially cancelled • William D. Reimert dies, Ursinus Board President • Dr. E. Lewis\u27 math textbook aids Ursinus blind students • Pre-Med convention • Dean Harris weds Bryn Mawr man • Editorial: A very good year • Focus: Mike Stoner in exile • Compulsory convocation: Its validity and purpose • New view of Ursinus • Dr. Rice endorses Vietnam moratorium • Kitchen cynic: Suppose U.C. had mandatory convocations • Perspectives • To eat or not to eat • Board names new members • Spotlight: Mr. Jones, cook • Centennial plans • Opinion: Suggestions for revision of the school calendar • Weaver raps • Faculty portrait: Mrs. Lucas • Woodstock vs. Ursinus • Essay on the new age • Building plans • Freshman class • Harriers extend streak to 26 • Shuman, Mangan potential greats • Flying Dutchmen edge Bears on late T.D. • Ursinus drops grid opener to Diplomats • Registration system analyzed • Lack of needed funds signals impending collapse of agency • Astronaut Scott Carpenter opens Fall Forum series • Ursinus accounting students rank first twice, and secondhttps://digitalcommons.ursinus.edu/weekly/1149/thumbnail.jp

The Ursinus Weekly, October 24, 1969

Six seniors vie for Homecoming Queen • Ursinus students, faculty observe nationwide Vietnam Moratorium; Hundreds attend night procession • President\u27s statement • Editorial: A day of moratorium, a lifetime of commitment • Focus: Vicki Van Horn • Byerly probes Moratorium, SFARC • The psychiatrist is in • In our mail bag: Sig Nu replies; Moratorium Day; Orientation • Interaction • Deprived students complain • Faculty portrait: Mr. Ehrlich • In the spotlight: Mr. Prindle, custodian • Administration answers: Scholarship cancellations • Sisters speak • Wailing wall shouts • Better homes • Student body rejects current US draft system • Ursinus on display for annual Parents Day fete • Ursinus hosts studies group • Bill Brown elected frosh president • Ten Ursinus seniors selected for \u2770 Who\u27s Who rating • Late Ursinus pass downs Mules • Bear football tide turning • Bakermen even record; Team called balanced • Harriers cop 28th straight • Soph phenom Cash leads Bearettes • October 15, 1969: Vietnam Moratorium at Ursinushttps://digitalcommons.ursinus.edu/weekly/1150/thumbnail.jp

The Ursinus Weekly, March 6, 1969

Officers inducted; Emig emphasizes new responsibility • American dream, brotherhood highlight Festival of the Arts • USGA officers interviewed; Communication gap stressed • Placement interviews scheduled • 200 attend Lorelei; Fischer crowned king • Semi-formal ball highlights junior-senior weekend • Editorial: Potpourri - Or, Could this ever happen here? • State set to punish protestors; Laws threaten civil liberties • Letters to the editor • Remark • Lantern literary lapse termed titanic bomb • Staying out of uniform: A practical guide for the Ursinus male, part I • Whose risk? • Columnist proposes solution to UC\u27s dearth of black students • Albright draws Fifth Dimension • Racism symposium set for March 20 with Lincoln Univ. • Dorm lounges opened; Slacks rule slackened • Rice discusses status for Phi Beta Kappa • Ursinus grapplers rally to win over Drexel, 22-13 • New gym complex to include pool • Carson paces Bearettes over Gettysburg • Badminton team wins six in row • Trackmen run at Swarthmore and Delaware • Gillespie hits 37 points to lead Bears over Swarthmore in finale • Girl swimmers win over Penn and Elizabethtown • Junior varsity hoopmen finish with 11-6 record • Dickinson frat system defended • UC celebrates centennial with unique innovation • Forum features Howellhttps://digitalcommons.ursinus.edu/weekly/1171/thumbnail.jp

The Naturalistic Flight Deck System: An Integrated System Concept for Improved Single-Pilot Operations

This paper reviews current and emerging operational experiences, technologies, and human-machine interaction theories to develop an integrated flight system concept designed to increase the safety, reliability, and performance of single-pilot operations in an increasingly accommodating but stringent national airspace system. This concept, know as the Naturalistic Flight Deck (NFD), uses a form of human-centered automation known as complementary-automation (or complemation) to structure the relationship between the human operator and the aircraft as independent, collaborative agents having complimentary capabilities. The human provides commonsense knowledge, general intelligence, and creative thinking, while the machine contributes specialized intelligence and control, extreme vigilance, resistance to fatigue, and encyclopedic memory. To support the development of the NFD, an initial Concept of Operations has been created and selected normal and non-normal scenarios are presented in this document