Prevention and treatment of venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency

Objective: The aims of the study reported here were to provide data from six pregnant subjects who were enrolled in a clinical trial of antithrombin (AT) concentrate, discuss other published case series and case reports, and provide general guidance for the use of AT concentrate for inherited AT deficiency in pregnancy. Methods: In the late 1980s, 31 AT-deficient subjects were enrolled in a prospective treatment trial of the plasma-derived AT concentrate Thrombate III®. Herein, newly available treatment data about the six pregnant subjects in the trial is tabulated and summarized. Results: All six experienced venous thromboembolism (VTE) during pregnancy, were dosed according to a weight-based protocol, and were treated concomitantly with anticoagulation. Loading doses of AT concentrate of 54–62 units/kg were followed by maintenance doses of 50%–100% of the loading dose for 3–10 days. At the time of labor, loading doses of 46–50 units/kg were followed by maintenance doses of 50%–75% of the loading dose for 5–7 days. None of the six experienced recurrent thrombosis while receiving treatment with AT concentrate. Conclusion: Currently we suggest that women with AT deficiency who are pregnant or postpartum and have a personal history of VTE or current VTE receive AT concentrates

Clustering Hyperspectral Imagery for Improved Adaptive Matched Filter Performance

This paper offers improvements to adaptive matched filter (AMF) performance by addressing correlation and non-homogeneity problems inherent to hyperspectral imagery (HSI). The estimation of the mean vector and covariance matrix of the background should be calculated using “target-free” data. This statement reflects the difficulty that including target data in estimates of the mean vector and covariance matrix of the background could entail. This data could act as statistical outliers and severely contaminate the estimators. This fact serves as the impetus for a 2-stage process: First, attempt to remove the target data from the background by way of the employment of anomaly detectors. Next, with remaining data being relatively “target-free” the way is cleared for signature matching. Relative to the first stage, we were able to test seven different anomaly detectors, some of which are designed specifically to deal with the spatial correlation of HSI data and/or the presence of anomalous pixels in local or global mean and covariance estimators. Relative to the second stage, we investigated the use of cluster analytic methods to boost AMF performance. The research shows that accounting for spatial correlation effects in the detector yields nearly “target-free” data for use in an AMF that is greatly benefitted through the use of cluster analysis methods

Exact field ionization rates in the barrier suppression-regime from numerical TDSE calculations

Numerically determined ionization rates for the field ionization of atomic hydrogen in strong and short laser pulses are presented. The laser pulse intensity reaches the so-called "barrier suppression ionization" regime where field ionization occurs within a few half laser cycles. Comparison of our numerical results with analytical theories frequently used shows poor agreement. An empirical formula for the "barrier suppression ionization"-rate is presented. This rate reproduces very well the course of the numerically determined ground state populations for laser pulses with different length, shape, amplitude, and frequency. Number(s): 32.80.RmComment: Enlarged and newly revised version, 22 pages (REVTeX) + 8 figures in ps-format, submitted for publication to Physical Review A, WWW: http://www.physik.tu-darmstadt.de/tqe

Photometric observations of selected, optically bright quasars for Space Interferometry Mission and other future celestial reference frames

Photometric observations of 235 extragalactic objects that are potential targets for the Space Interferometry Mission (SIM) are presented. Mean B, V, R, I magnitudes at the 5% level are obtained at 1 - 4 epochs between 2005 and 2007 using the 1-m telescopes at Cerro Tololo Inter-American Observatory and Naval Observatory Flagstaff Station. Of the 134 sources which have V magnitudes in the Veron & Veron-Cetty catalog a difference of over 1.0 mag is found for the observed-catalog magnitudes for about 36% of the common sources, and 10 sources show over 3 mag difference. Our first set of observations presented here form the basis of a long-term photometric variability study of the selected reference frame sources to assist in mission target selection and to support in general QSO multi-color photometric variability studies.Comment: 40 pages, 13 figures, 4 table

FIRE Spectroscopy of Five Late-type T Dwarfs Discovered with the Wide-field Infrared Survey Explorer

We present the discovery of five late-type T dwarfs identified with the Wide-field Infrared Survey Explorer (WISE). Low-resolution near-infrared spectroscopy obtained with the Magellan Folded-port InfraRed Echellette (FIRE) reveal strong water and methane absorption in all five sources, and spectral indices and comparison to spectral templates indicate classifications ranging from T5.5 to T8.5:. The spectrum of the latest-type source, WISE J1812+2721, is an excellent match to that of the T8.5 companion brown dwarf Wolf 940B. WISE-based spectrophotometric distance estimates place these T dwarfs at 12-13 pc from the Sun, assuming they are single. Preliminary fits of the spectral data to the atmosphere models of Saumon & Marley indicate effective temperatures ranging from 600 K to 930 K, both cloudy and cloud-free atmospheres, and a broad range of ages and masses. In particular, two sources show evidence of both low surface gravity and cloudy atmospheres, tentatively supporting a trend noted in other young brown dwarfs and exoplanets. In contrast, the high proper motion T dwarf WISE J2018-7423 exhibits a suppressed K-band peak and blue spectrophotometric J-K colors indicative of an old, massive brown dwarf; however, it lacks the broadened Y-band peak seen in metal-poor counterparts. These results illustrate the broad diversity of low-temperature brown dwarfs that will be uncovered with WISE.Comment: 19 pages, 13 figures; accepted for publication to Ap

Malware Type Recognition and Cyber Situational Awareness

Current technologies for computer network and host defense do not provide suitable information to support strategic and tactical decision making processes. Although pattern-based malware detection is an active research area, the additional context of the type of malware can improve cyber situational awareness. This additional context is an indicator of threat capability thus allowing organizations to assess information losses and focus response actions appropriately. Malware Type Recognition (MaTR) is a research initiative extending detection technologies to provide the additional context of malware types using only static heuristics. Test results with MaTR demonstrate over a 99% accurate detection rate and 59% test accuracy in malware typing

Malware Target Recognition via Static Heuristics

Organizations increasingly rely on the confidentiality, integrity and availability of their information and communications technologies to conduct effective business operations while maintaining their competitive edge. Exploitation of these networks via the introduction of undetected malware ultimately degrades their competitive edge, while taking advantage of limited network visibility and the high cost of analyzing massive numbers of programs. This article introduces the novel Malware Target Recognition (MaTR) system which combines the decision tree machine learning algorithm with static heuristic features for malware detection. By focusing on contextually important static heuristic features, this research demonstrates superior detection results. Experimental results on large sample datasets demonstrate near ideal malware detection performance (99.9+% accuracy) with low false positive (8.73e-4) and false negative rates (8.03e-4) at the same point on the performance curve. Test results against a set of publicly unknown malware, including potential advanced competitor tools, show MaTR’s superior detection rate (99%) versus the union of detections from three commercial antivirus products (60%). The resulting model is a fine granularity sensor with potential to dramatically augment cyberspace situation awareness

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

Thrombophilias are hereditary and/or acquired conditions that predispose patients to thrombosis. Testing for thrombophilia is commonly performed in patients with venous thrombosis and their relatives; however such testing usually does not provide information that impacts management and may result in harm. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance for thrombophilia testing in five clinical situations: following 1) provoked venous thromboembolism, 2) unprovoked venous thromboembolism; 3) in relatives of patients with thrombosis, 4) in female relatives of patients with thrombosis considering estrogen use; and 5) in female relatives of patients with thrombosis who are considering pregnancy. Additionally, guidance is provided regarding the timing of thrombophilia testing. The role of thrombophilia testing in arterial thrombosis and for evaluation of recurrent pregnancy loss is not addressed. Statements are based on existing guidelines and consensus expert opinion where guidelines are lacking. We recommend that thrombophilia testing not be performed in most situations. When performed, it should be used in a highly selective manner, and only in circumstances where the information obtained will influence a decision important to the patient, and outweigh the potential risks of testing. Testing should not be performed during acute thrombosis or during the initial (3-month) period of anticoagulation