272 research outputs found
Transformations in Early Historic and Early Medieval India: Excavations at Paithan, Maharashtra 1996-1999.
Transformations in Early Historic and Early Medieval India: Excavations at Paithan, Maharashtra 1996-1999 (Delhi: Archaeological Survery of India and British Association for South Asian Studies, 2015)
DO INDUSTRIAL CLASSIFICATIONS NEED RE-INVENTINg? AN ANALYSIS OF THE RELEVANCE OF THE U.S. SIC SYSTEM FOR PRODUCTIVITY RESEARCH
Two separate empirical investigations into the conceptual structure underlying the U.S. SIC were undertaken. Government industry specialists and industry classification experts reviewed individual4-digit U.S. SICs and judgmentally determined if these industries had been constructed by grouping similar production processes, or, alternatively, by grouping similar markets. Independently, an algorithm derived from the diversification index developed by Gollop and Monahan (1991) was used to measure the heterogeneity of establishment production functions, by 4-digit industry, using the Census Longitudinal Research Database file. The two reviews yielded broadly similar results: Only about one fifth of US. industries have been designed to be approximately consistent with aggregation conditions derived from production theory
Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).
A barrier to the successful development of new disease treatments is the timely recruitment of participants to experimental medicine studies that are primarily designed to investigate biological mechanisms rather than evaluate clinical efficacy. The aim of this study was to analyse the performance of three recruitment sources and the effect of publicity events during the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).This work is funded by the JDRF (9-2011-253), the Wellcome Trust (091157) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement number 241447 (NAIMIT). The Cambridge Institute for Medical Research (CIMR) is in receipt of a Wellcome Trust Strategic Award (100140).This is the final version of the article. It first appeared from BMC via http://dx.doi.org/10.1186/s13063-015-0583-
CP violating neutrino oscillation and uncertainties in Earth matter density
We propose a statistical formulation to estimate possible errors in long
baseline neutrino oscillation experiments caused by uncertainties in the Earth
matter density. A quantitative investigation of the effect is made on the CP
asymmetry in future neutrino factory experiments.Comment: Latex, 10 pages, 5 figure
Measuring CP violation and mass ordering in joint long baseline experiments with superbeams
We propose to measure the CP phase , the magnitude of the
neutrino mixing matrix element and the sign of the atmopheric scale
mass--squared difference with a superbeam by the joint
analysis of two different long baseline neutrino oscillation experiments. One
is a long baseline experiment (LBL) at 300 km and the other is a very long
baseline (VLBL) experiment at 2100 km. We take the neutrino source to be the
approved high intensity proton synchrotron, HIPA. The neutrino beam for the LBL
is the 2-degree off-axis superbeam and for the VLBL, a narrow band superbeam.
Taking into account all possible errors, we evaluate the event rates required
and the sensitivities that can be attained for the determination of
and the sign of . We arrive at a
representative scenario for a reasonably precise probe of this part of the
neutrino physics.Comment: 25 RevTEX pages, 16 PS figures, revised figure captions and
references adde
Socioeconomic Indicators and the Risk of Acute Coronary Heart Disease Events: Comparison of Population-Based Data from the United States and Finland
We wished to determine whether a gradient of association of low socioeconomic status with incidence of coronary heart disease was present in two population-based cohorts, one from United States the other from Finland
Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.
INTRODUCTION: Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing β cells in the pancreatic islets, leading to insulinopenia and hyperglycaemia. Genetic analyses indicate that alterations of the interleukin-2 (IL-2) pathway mediating immune activation and tolerance predispose to T1D, specifically the polymorphic expression of the IL-2 receptor-α chain (CD25) on T lymphocytes. Replacement of physiological doses of IL-2 could restore self-tolerance and prevent further autoimmunity by enhancing the function of CD4(+) T regulatory cells (Tregs) to limit the activation of auto reactive T effector cells (Teffs). In this experimental medicine study, we use an adaptive trial design to determine the optimal dosing regimen for IL-2 to improve Treg function while limiting activation of Teffs in participants with T1D. METHODS AND ANALYSIS: The Adaptive study of IL-2 dose frequency on Tregs in type 1 diabetes(DILfrequency) is a mechanistic, non-randomised, repeat dose open-label, response-adaptive study of 36 participants with T1D. The objective is to establish the optimal dose and frequency of ultra-low dose IL-2: to increase Treg frequency within the physiological range, to increase CD25 expression on Tregs, without increasing CD4(+) Teffs. DILfrequency has an initial learning phase where 12 participants are allocated to six different doses and frequencies followed by an interim statistical analysis. After analysis of the learning phase, the Dose and Frequency Committee will select the optimal targets for Treg frequency, Treg CD25 expression and Teff frequency. Three groups of eight participants will be treated consecutively in the confirming phase. Each dose and frequency selected will be based on statistical analysis of all data collected from the previous groups. ETHICS: Ethical approval for DILfrequency was granted on 12 August 2014. RESULTS: The results of this study will be reported, through peer-reviewed journals, conference presentations and an internal organisational report. TRIAL REGISTRATION NUMBERS: NCT02265809, ISRCTN40319192, CRN17571.This work is funded by The Sir Jules Thorn Award for Biomedical Research 2013 (13/JTA), the JDRF (9-2011-253), the Wellcome Trust (091157) and the National Institute for Health Research Cambridge Biomedical Research Centre. The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award (100140). AM was supported by the Medical Research Council [grant number G0800860] and the National Institute for Health Research Cambridge Biomedical Research Centre.This is the final version of the article. It was first available from BMJ via http://dx.doi.org/10.1136/bmjopen-2015-00979
Modeling realistic Earth matter density for CP violation in neutrino oscillation
We examine the effect of a more realistic Earth matter density model which
takes into account of the local density variations along the baseline of a
possi ble 2100 km very long baseline neutrino oscillation experiment. Its
influence to the measurement of CP violation is investigated and a comparison
with the commonly used global density models made. Significant differences are
found in the comparison of the results of the different density models.Comment: 16 pages, 8 figure
Observations of the radial velocity of the Sun as measured with the novel SONG spectrograph:results from a 1-week campaign
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