2 research outputs found
Variations in Aggregation Structures and Fluorescence Properties of a Semialiphatic Fluorinated Polyimide Induced by Very High Pressure
Variations in the molecular aggregation structures and
optical
properties of a semialiphatic fluorinated 10FEDA/DCHM (polyÂ(4,4′-diaminocyclohexylmethane
1,4-bisÂ(3,4-dicarboxytrifluorophenoxy) tetrafluorobenzeneimide) polyimide
(PI), which exhibits strong cyan fluorescence, were examined under
very high pressure up to 8 GPa using synchrotron wide-angle X-ray
diffraction (WAXD) and fluorescence spectroscopy. The fluorescence
intensity of a PI film imidized at 220 °C was significantly reduced
by applying pressure up to 1 GPa, which should be due to an appreciable
reduction in interchain free volume, as indicated by a decrease in
the <i>d</i>-spacing values of WAXD peaks which correspond
to intermolecular ordering. In contrast, a PI film imidized at 300
°C, which exhibited weaker fluorescence than that imidized at
220 °C at atmospheric pressure, demonstrated a much smaller reduction
in fluorescence intensity below 1 GPa. Such differences in pressure
dependence clearly reflect the degrees of PI chain packing formed
at different imidization temperatures. These phenomena induced by
high pressure were almost reversible between pre- and postpressurization
states with small hysteresis in the WAXD patterns and fluorescence
spectra
Efficacy and safety of mycophenolate mofetil for steroid reduction in neuromyelitis optica spectrum disorder: a prospective cohort study
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease that can affect multiple generations and cause complications with long-term prednisolone treatment. This study aimed to evaluate the efficacy and safety of mycophenolate mofetil (MMF) in preventing NMOSD relapse while reducing prednisolone dosage. The trial involved nine patients with NMOSD who received MMF along with prednisolone dose reduction. MMF was effective in achieving prednisolone dose reduction without relapse in 77.8% of patients, with a significant decrease in mean annualized relapse rate. All adverse events were mild. The findings suggest that MMF could be a viable treatment option for middle-aged and older patients who require steroid reduction. Clinical trial registration number: jRCT, jRCTs051180080. Registered February 27th, 2019-retrospectively registered, https://jrct.niph.go.jp/en-latest-detail/jRCTs051180080.</p