Uncertainty quantification in the machine-learning inference from neutron star probability distribution to the equation of state

We discuss the machine-learning inference and uncertainty quantification for the equation of state (EoS) of the neutron star (NS) matter directly using the NS probability distribution from the observations. We previously proposed a prescription for uncertainty quantification based on ensemble learning by evaluating output variance from independently trained models. We adopt a different principle for uncertainty quantification to confirm the reliability of our previous results. To this end, we carry out the MC sampling of data to infer an EoS and take the convolution with the probability distribution of the observational data. In this newly proposed method, we can deal with arbitrary probability distribution not relying on the Gaussian approximation. We incorporate observational data from the recent multimessenger sources including precise mass measurements and radius measurements. We also quantify the importance of data augmentation and the effects of prior dependence.Comment: 34 pages, 2 tables, 13 figures, v2: minor correction, references adde

Key Interactions in Integrin Ectodomain Responsible for Global Conformational Change Detected by Elastic Network Normal-Mode Analysis

AbstractIntegrin, a membrane protein with a huge extracellular domain, participates in cell-cell and cell-extracellular-matrix interactions for metazoan. A group of integrins is known to perform a large-scale structural change when the protein is activated, but the activation mechanism and generality of the conformational change remain to be elucidated. We performed normal-mode analysis of the elastic network model on integrin αVβ3 ectodomain in the bent form and identified key residues that influenced molecular motions. Iterative normal-mode calculations demonstrated that the specific nonbonded interactions involving the key residues work as a snap to keep integrin in the bent form. The importance of the key residues for the conformational change was further verified by mutation experiments, in which integrin αIIbβ3 was used. The conservation pattern of amino acid residues among the integrin family showed that the characteristic pattern of residues seen around these key residues is found in the limited groups of integrin β-chains. This conservation pattern suggests that the molecular mechanism of the conformational change relying on the interactions found in integrin αVβ3 is unique to the limited types of integrins

Discovery of X rays from Class 0 protostar candidates in OMC-3

We have observed the Orion Molecular Clouds 2 and 3 (OMC-2 and OMC-3) with the Chandra X-ray Observatory (CXO). The northern part of OMC-3 is found to be particularly rich in new X-ray features; four hard X-ray sources are located in and along the filament of cloud cores. Two sources coincide positionally with the sub$mm$-$mm$ dust condensations of MMS 2 and 3 or an outflow radio source VLA 1, which are in a very early phase of star formation. The X-ray spectra of these sources show an absorption column of (1-3) x 10^23 H cm-2. Assuming a moderate temperature plasma, the X-ray luminosity in the 0.5-10 keV band is estimated to be ~10^30 erg s^-1 at a distance of 450 pc. From the large absorption, positional coincidence and moderate luminosity, we infer that the hard X-rays are coming from very young stellar objects embedded in the molecular cloud cores. We found another hard X-ray source near the edge of the dust filament. The extremely high absorption of 3 x 10^23 H cm^-2 indicates that the source must be surrounded by dense gas, suggesting that it is either a YSO in an early accretion phase or a Type II AGN (e.g. a Seyfert 2), although no counterpart is found at any other wavelength. In contrast to the hard X-ray sources, soft X-ray sources are found spread around the dust filaments, most of which are identified with IR sources in the T Tauri phase.Comment: 9 pages, To be appeared in ApJ v554 n2 Jun 20, 2001 issue, related press release is available at http://science.psu.edu/alert/Tsuboi11-2000.htm, Figure 1 and figure 2 with the best resolution is available at ftp.astro.psu.edu/pub/tsuboi/OMC/010205

The Excimer Lamp Induces Cutaneous Nerve Degeneration and Reduces Scratching in a Dry-Skin Mouse Model

Epidermal hyperinnervation, which is thought to underlie intractable pruritus, has been observed in patients with atopic dermatitis (AD). The epidermal expression of axonal guidance molecules has been reported to regulate epidermal hyperinnervation. Previously, we showed that the excimer lamp has antihyperinnervative effects in nonpruritic dry-skin model mice, although epidermal expression of axonal guidance molecules was unchanged. Therefore, we investigated the antipruritic effects of excimer lamp irradiation and its mechanism of action. A single irradiation of AD model mice significantly inhibited itch-related behavior 1 day later, following improvement in the dermatitis score. In addition, irradiation of nerve fibers formed by cultured dorsal root ganglion neurons increased bleb formation and decreased nerve fiber expression of nicotinamide mononucleotide adenylyl transferase 2, suggesting degenerative changes in these fibers. We also analyzed whether attaching a cutoff excimer filter (COF) to the lamp, thus decreasing cytotoxic wavelengths, altered hyperinnervation and the production of cyclobutane pyrimidine dimer (CPD), a DNA damage marker, in dry-skin model mice. Irradiation with COF decreased CPD production in keratinocytes, as well as having an antihyperinnervative effect, indicating that the antipruritic effects of excimer lamp irradiation with COF are due to induction of epidermal nerve degeneration and reduced DNA damage

Advanced moderately differentiated neuroendocrine carcinoma of the rectum with favorable prognosis by postoperative chemoradiation

Rectal neuroendocrine carcinoma is rare with poor prognosis. We report herein a case of advanced moderately differentiated neuroendocrine carcinoma of the rectum with relatively favorable prognosis treated by postoperative adjuvant chemoradiation therapy. A 58-year-old Japanese female was referred and colonofiberscopy revealed an easy-bleeding irregular tumor in the lower rectum, which was pathologically diagnosed as a neuroendocrine carcinoma. Surgical treatment consisted of abdominoperineal resection and lymph node dissection. The tumor invaded deeply into perirectal tissues, and 9 of 11 lymph node metastases were observed. Immunohistochemically, chromogranin A showed diffuse and strong staining, and the MIB-1 labeling index was 18.3 ± 5.6, supporting the high proliferation of the tumor. Some nucleus of the tumor showed positive staining for p21/WAF1. A total dose of 46 Gy of radiotherapy was delivered with 800 mg of daily oral doxifluridine. At 5 years post-surgery, the patient demonstrated no clinical evidence of intrapelvic recurrence or distant metastases

The first isolation of Aspergillus allahabadii from a cormorant with pulmonary aspergillosis

In this study, we report the first isolation of Aspergillus allahabadii from a Japanese cormorant with pulmonary aspergillosis. We performed molecular identification and antifungal susceptibility testing with the E-test. A 7-month-old male cormorant died because of uric acid deposition secondary to dehydration. Whitish nodular lesions were present on the caudal thoracic air sac in the right thoracic cavity. Histopathology revealed multifocal pyogranulomatous necrotic lesions with numerous fungal hyphae in the thoracic air sac. Identification of the etiologic agent was confirmed by comparative analyses of the sequences of the internal transcribed spacer (ITS) region and β-tubulin-encoding genes. According to the E-test, the minimum inhibitory concentrations of the isolate to amphotericin B, fluconazole, itraconazole, and voriconazole were 0.75 μg/ml, >256 μg/ml, 0.38 μg/ml, and 0.38 μg/ml, respectively

Fate of Polycyclic Aromatic Hydrocarbons and Radionuclides through Loess over Pan-Japan Sea Area -Reaction, Transportation and Deposition-

金沢大学大学院自然科学研究科金沢大学工学部Nankai, UniversityChinese Academy of SciencesScedule:17-18 March 2003, Vemue: Kanazawa, Japan, Kanazawa Citymonde Hotel, Project Leader : Hayakawa, Kazuichi, Symposium Secretariat: XO kamata, Naoto, Edited by:Kamata, Naoto