Additional file 1: Table S1. of Comparison between two amplicon-based sequencing panels of different scales in the detection of somatic mutations associated with gastric cancer

Panel description and references. Table S2. Cutting areas of ESD-resected specimens (n=19) by laser capture microdissection and biopsies (n=2). Table S3. Assessment of tumor-derived DNA qualities. (XLS 43 kb

Successful Resection of Intracranial Metastasis of Hepatocellular Carcinoma

Intracranial metastasis of hepatocellular carcinoma (HCC) is rare, but has an extremely poor prognosis. We report a case with successful surgical removal of intracranial metastasis of HCC. A 32-year-old man was admitted to our hospital with severe vomiting. He had been followed for liver cirrhosis due to hepatitis B virus infection and received a right hepatic trisectionectomy for HCC 1 year earlier. For the recurrence of HCC, sorafenib had been administered 6 months before admission. On admission, he exhibited consciousness disturbance, which gradually worsened. Two days later, both computed tomography and magnetic resonance imaging revealed an intra-axial tumor with perifocal edema and hemorrhage in the left frontal lobe. The tumor was successfully removed by craniotomy and pathological examination revealed that it was composed of moderately differentiated HCC cells. The day after surgical resection of the tumor, his consciousness returned to normal. Subsequently, he was treated with hepatic arterial infusion chemotherapy with 5-fluorouracil and cisplatin using an implanted port-catheter system. Surgical resection of intracranial metastasis of HCC would be important and meaningful in some cases

Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma.

As there are no reports of studies in patients with pelvic chondrosarcoma treated with carbon ion radiotherapy (CIRT), the aim of this study was to evaluate the applicability of CIRT for patients with chondrosarcoma of the pelvis

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma

Background. The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Methods. A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 (not detectable) were evaluated by three trainees and three experts using white light imaging (WLI), LCI mode, and blue laser imaging bright (BLI-b) mode. In addition, L∗a∗b∗ color values and color differences (ΔE∗) were evaluated using the CIELAB color space system. Results. The visibility score of the BE in LCI mode (2.94±1.32) was significantly higher than those in WLI (2.46±1.48) and BLI-b mode (2.35±1.46) (p<0.01). The color difference (ΔE∗) from the adjacent gastric mucosa in LCI mode (17.11±8.53) was significantly higher than those in other modes (12.52±9.37 in WLI and 11.96±6.59 in BLI-b mode, p<0.01). The visibility scores of EAC in LCI mode (2.56±1.47) and BLI-b mode (2.51±1.28) were significantly higher than that in WLI (1.64±1.46) (p<0.01). The color difference (ΔE∗) from the adjacent normal Barrett’s mucosa in LCI mode (19.96±7.97) was significantly higher than that in WLI (12.95±11.86) (p=0.03). Conclusion. The present findings suggest that LCI increases the visibility of BE and EAC and contributes to the improvement of the detection of these lesions