Small Angle X-Ray Scattering Imaging of Soft Tissue by Using Laue Diffraction Optical System

We performed a feasibility study of Small angle X-ray scattering imaging under the condition of X-ray bright field imaging by Laue crystal diffraction optics of X-ray dark-field imaging that works as an angular analysis. Collagen in chicken tibia containing abundant soft fibrous tissue was chosen as a specimen. In traditional Small angle X-ray scattering optical system, we can derive the structure information of sample by calculating q value which is available from a scattering pattern. Thus it is usually necessary to conduct a 2D scan in order to obtain scattering image. In this paper it is described by a method by which not only small angle X-ray scattering imaging is available directly but also bright-field imaging and dark-field imaging can be obtained at the same time. As the first step, the feasibility of the imaging method should be confirmed by taking pictures of the samples with known periodic length. The preliminary test showed that the collgan’s lattice spacing d is 65.1 nm that was also taken photos by scanning electron microscopy. By rotating Laue angular analyzer by 112 arcseconds small angle X-ray scattering image appeared in bright-field

Is the “Seikatsu Bamen Mensetsu” the “Life Space Interview”? –Consideration as a term–

本研究は，レドルの Life Space Interview の訳語が「生活場面面接」で妥当か検討するため，その用語（訳語）と説明から検証する研究である．1990 年代まで国内では生活場面面接に関する研究論文がない．その実態のなかで “Life Space Interview” の用語が入っている限られた国内文献を調査対象としている．その調査研究の結果，レヴィンの「場の理論」における「生活空間」との関連等から「生活空間面接」が妥当と結論づけた．また，辞典等では，その説明も十分でないことが判明した．レヴィンとの関連を明確にしたことが本研究の意義であるが，その理論的理解は今回の資料だけでは限界がある．場の理論を踏まえた生活場面面接の研究が課題である．departmental bulletin pape

6U CubeSat for Ultraviolet Time-Domain Astronomy

A wide-field ultraviolet observatory for time-domain astronomy utilizing 6U CubeSat is presented. Ultraviolet waveband is one of the unexplored fields in astronomy. Potential targets are short duration transient sources in UV-band: early-phase emission from gravitational wave sources, supernovae shock-breakouts, tidal disruption events around super massive blackholes, etc. The telescope was designed for covering the large error circle of GW detectors, FoV~100 deg2. Thanks to the high quantum efficiency of “delta-doping” detector, the detection limit achieves 20 mag (AB) for 1800 s exposure in NUV band, which is sufficient to detect UV emission from a binary neutron star merger within 200 Mpc from the earth. The satellite has a high-performance on-board computer for on-orbit analysis to detect transient sources and measure the magnitude and the accurate position of the target. The obtained information is required to be transferred to the ground within 30 min from the detection to start multi-messenger follow-up observations utilizing ground-based observatories and astronomical satellites. In this presentation we show the mission overview and conceptual design of the satellite system

The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema

金沢大学医薬保健研究域医学

The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis

C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with beta 2-glycoprotein I (beta 2GPI), implicating oxLDL/P2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/beta 2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/R2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and beta 2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of adierosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/beta 2GPI complexes correlated with total cholesterol and hemoglobin Al c. Thus, the generation of CRP/oxLDL/beta 2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/R2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis