Cluster Entropy: Active Domain Adaptation in Pathological Image Segmentation

The domain shift in pathological segmentation is an important problem, where a network trained by a source domain (collected at a specific hospital) does not work well in the target domain (from different hospitals) due to the different image features. Due to the problems of class imbalance and different class prior of pathology, typical unsupervised domain adaptation methods do not work well by aligning the distribution of source domain and target domain. In this paper, we propose a cluster entropy for selecting an effective whole slide image (WSI) that is used for semi-supervised domain adaptation. This approach can measure how the image features of the WSI cover the entire distribution of the target domain by calculating the entropy of each cluster and can significantly improve the performance of domain adaptation. Our approach achieved competitive results against the prior arts on datasets collected from two hospitals.Comment: Accepted by IEEE ISBI'2

Complexation of 4,4′-Dipyridyl Derivatives Changed the Orientations of Metalloporphyrins Linked to the Cyclic Peptide Gramicidin S

Pairs of Zn and Co(III) porphyrins linked to the natural cyclic β-sheet peptide, Gramicidin S, formed stable host-guest complexes with the 4,4′-dipyridyl derivatives in dichloromethane, in which the Cotton effects reflected the orientational changes of the metalloporphyrins upon the complexations

Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer

Purpose. Immune responses following stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) were examined from the point of view of lymphocyte subset counts and natural killer cell activity (NKA). Patients and Methods. Peripheral blood samples were collected from 62 patients at 4 time points between pretreatment and 4 weeks post-treatment for analysis of the change of total lymphocyte counts (TLC) and lymphocyte subset counts of CD3 + , CD4 + , CD8 + , CD19 + , CD56 + , and NKA. In addition, the changes of lymphocyte subset counts were compared between patients with or without relapse. Further, the correlations between SBRT-related parameters and immune response were analyzed for the purpose of revealing the mechanisms of the immune response. Results. All lymphocyte subset counts and NKA at post-treatment and 1 week post-treatment were significantly lower than pre-treatment ( < 0.01). No significant differences in the changes of lymphocyte subset counts were observed among patients with or without relapse. The volume of the vertebral body receiving radiation doses of 3 Gy or more (VV 3 ) significantly correlated with the changes of nearly all lymphocyte subset counts. Conclusions. SBRT for stage I NSCLC induced significant immune suppression, and the decrease of lymphocyte subset counts may be associated with exposure of the vertebral bone marrow

Rib fracture after stereotactic radiotherapy on follow-up thin-section computed tomography in 177 primary lung cancer patients

<p>Abstract</p> <p>Background</p> <p>Chest wall injury after stereotactic radiotherapy (SRT) for primary lung cancer has recently been reported. However, its detailed imaging findings are not clarified. So this study aimed to fully characterize the findings on computed tomography (CT), appearance time and frequency of chest wall injury after stereotactic radiotherapy (SRT) for primary lung cancer</p> <p>Materials and methods</p> <p>A total of 177 patients who had undergone SRT were prospectively evaluated for periodical follow-up thin-section CT with special attention to chest wall injury. The time at which CT findings of chest wall injury appeared was assessed. Related clinical symptoms were also evaluated.</p> <p>Results</p> <p>Rib fracture was identified on follow-up CT in 41 patients (23.2%). Rib fractures appeared at a mean of 21.2 months after the completion of SRT (range, 4 -58 months). Chest wall edema, thinning of the cortex and osteosclerosis were findings frequently associated with, and tending to precede rib fractures. No patients with rib fracture showed tumors > 16 mm from the adjacent chest wall. Chest wall pain was seen in 18 of 177 patients (10.2%), of whom 14 patients developed rib fracture. No patients complained of Grade 3 or more symptoms.</p> <p>Conclusion</p> <p>Rib fracture is frequently seen after SRT for lung cancer on CT, and is often associated with chest wall edema, thinning of the cortex and osteosclerosis. However, related chest wall pain is less frequent and is generally mild if present.</p

プロダクトデザインにおける地域・ローカル性の検証/ヘルシンキ–神戸「屋外の食事」

本研究・プロジェクトは、今後のプロダクトデザインのあり様を探るために、地域・ローカル性と言えるものが、日常生活でのプロダクト、そのデザインにどのような姿で表現されるかを検証しようと試みるものであり、ヘルシンキのアアルト大学と神戸芸術工科大学の二カ国のデザイン学生が各国独自の生活慣習に則って、一つのテーマを支える用品・道具をデザインした。プロジェクトの共通テーマを「屋外の食事」とし、アアルト大学はトリコユ（露店・オープンカフェ）、神戸芸術工科大学は花見のプロダクトとしてプロジェクトに取り組み、実際にデザインされた道具を用いて各大学がトリコユ、花見を行なった。その後、使用された作品はヘルシンキ、東京、神戸でそれぞれが持ち寄って、その場の雰囲気が理解できるような展示会を行なった。それぞれの作品は、共に各国の地域性を強く表わしたものとなったが、同時に国際性が高いとの評価も得た。共に外観スタイルとしては、地域性を出しながらも、プロダクトとしての品質の高さ、またシンプルな様相を呈していることが、今日のモダンデザインを基本とするデザイントレンドに合致していることもありそのような結果になったと思われるが、地域性と国際性が共に並立して評価できることを確認することができた。The aim of this project is to examine the local characteristics of design appears in the product of daily use in order to describe the future of the product design.Eating in Open Air is a common design theme of the project for the students from Aalto University, School of Arts, Design and Architecture, Finland and Kobe Design University, Japan. A group of students from both Universities run out their own projects under the common theme. Torikoju and Hanami were realized in each country with necessary equipments designed by students. The result of the work was brought together into three exhibitions in autumn 2012, first in Helsinki, then in Tokyo and Kobe. They were valued expressing not only of their local characteristics but also their international characteristics. Their simple style of their appearances adapts modern design trend seems to make the assessment. This proves both local and international characteristics can be estimated at the same time

Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes

Background: The number of patients suffering from diabetic nephropathy resulting in end-stage kidney disease is increasing worldwide. In clinical settings, there are limited data regarding the impact of the urinary albumin-to-creatinine ratio (UACR) and reduced estimated glomerular filtration rate (eGFR) on renal and cardiovascular outcomes and all-cause mortality. Methods: We performed a historical cohort study of 4328 Japanese participants with type 2 diabetes from 10 centers. Risks for renal events (requirement for dialysis or transplantation, or half reduction in eGFR), cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke), and all-cause mortality were assessed according to UACR and eGFR levels. Results: During follow-up (median 7.0 years, interquartile range 3.0-8.0 years), 419 renal events, 605 cardiovascular events and 236 deaths occurred. The UACR levels increased the risk and the adjusted hazard ratios for these three events. In addition to the effects of UACR levels, eGFR stages significantly increased the adjusted hazard ratios for renal events and all-cause mortality, especially in patients with macroalbuminuria. Diabetic nephropathy score, based on the prognostic factors, well predicted incidence rates per 1000 patient/year for each event. Conclusions: Increased UACR levels were closely related to the increase in risks for renal, cardiovascular events and all-cause mortality in Japanese patients with type 2 diabetes, whereas the association between high levels of UACR and reduced eGFR was a strong predictor for renal events. © 2013 Japanese Society of Nephrology

創造都市におけるコミュニケーションデザイン/神戸ビエンナーレ2013 の視点から

神戸ビエンナーレ2013 のメイン会場・メリケンパークに、会期限定でオープンした輸送用コンテナを利用した公式デザインショップの企画とデザイン、及びその展開についての研究。このプロジェクトは、これまでのアートの概念を越えた新しい表現や価値、都市の魅力の創生をコンセプトに開催される神戸ビエンナーレにおいて、神戸芸術工科大学が保有するリソースを活かし地元企業との連携で、オリジナルグッズの企画・開発から空間デザイン、運営までをトータルに行った、地場産業と地域活性化のための新しい試みである。開発プロダクトをプレゼンテーションするためのショップとスタンドを併設し、アートを接点に都市に集う多種多様な人々の交流をテーマにデザインした。また、同じくビエンナーレ会場である灘区・ミュージアムロードの公共施設で、研究で制作した３基の展示什器を使用し、市民を対象にしたデザインとアートによる地域交流や体験を深めるコンテンツを展開した。This study is about the planning, design and deployment at Meriken Park, the main venue for KOBE Biennale 2013, featured official design shop housed in shipping container, operating only for the duration of the event. Drawing on the resources of Kobe Design University, this project was a new attempt at revitalizing the region and local industry for which we provided a total service, from the planning of the original goods to the spatial design and actual operation stages. Our design theme was the exchange of the great diversity of people who congregate in cities, with art as their contact point. In addition, at the Museum Road in Nada-ku where is also the venue of KOBE Biennale 2013, we installed three display furniture in public facilities along the road and, in the spaces created by their placement, worked with students and artists to hold exhibits and workshops on design and art aimed at local residents