SHED, PRF, and Chitosan as Three-Dimensional of Tissue Engineering for Dental Pulp Regeneration

The gold standard for pulpitis irreversible treatment is root canal treatment. However, it caused the loss of tooth vitality. To restore tooth vitality, materials that have regenerative ability in the pulp is needed. The exfoliated deciduous teeth stem cells (SHED) not only expressed specific markers for mesenchymal stem cells (MSC) but also induced the odontoblastic differentiation, and stimulating the formation of endothelium and fibroblast. The combination SHED with platelet rich fibrin (PRF) and chitosan were able to facilitate and increase the migration, proliferation and odontoblastic differentiation of dental pulp cells. Based on that fact, the combination of SHED, PRF and chitosan as three-dimensional tissue engineering is promising as new modality to pulp regeneration in the clinical setting. The purpose of this review is describing the potential combination of SHED, PRF, and chitosan scaffold as three-dimensional tissue engineering for pulp regeneration

The Level of Knowledge of Dental Profession Students of Universitas Airlangga on Leukoplakia as an Oral Potentially Malignant Disorder: An Observational Analytic Cross-Sectional Study

Introduction Some oral cancers are preceded by oral potentially malignant disorders (OPMD), clinically and histologicallycharacterized byepithelial dysplasia. Leukoplakia is one of the OPMDs which clinically categorized into homogenous and nonhomogenous. Nonhomogeneous leukoplakia has a higher potential for malignant change. Therefore, dentists are required to recognize leukoplakia early during an oral (visual) examination, and this competency must be one of the requirements before graduation. Objective This study aimed to understand the level of knowledge of the dental undergraduate students about leukoplakia as an OPMD. Methods This research was an observational analytic study using a cross-sectional design. Data were collected via a questionnaire survey conducted using Google Forms. The total score was divided into high (9–12), medium (5–8), and low (0–4). Data were analyzed using SPSS version 25 using comparative analysis Mann–Whitney techniques test. Results A total of 180 dental profession students completed the questionnaire. Of these, 74 (41.40%) respondents were 22 years old, and 146 (81.10%) respondents were female. A high level of knowledge was achieved by 130 (72.20%) respondents, with each revealing 68 respondents from the 2019 batch and 62 from the 2018 batch, 49 (27.20%) respondents with a medium level of knowledge with 26 from the 2018 batch and 23 from the 2019 batch, and 1 respondent (0.60%) from the 2019 batch with a low level of knowledge. The results showed a p-value of 0.211