10 research outputs found
S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects
Background
In acute HIV-1 infection (AHI) there are infectioninduced
polyclonal shifts in blood and bone marrow Bcell
subsets from naïve to memory cells and plasmablasts/
plasma cells (PCs) coupled with decreased numbers of
naive B cells. To study the initial antibody response to
HIV, we have used recombinant technology to create a
database of PC antibody sequences derived from 3 early
stage AHI subjects