On-Campus Occupational Therapy Clinic: Exploring a Supervision Model for Level I Fieldwork Within Curriculum

This study explored how a revised on-campus occupational therapy clinic model impacted occupational therapy graduate student professional development and clinical practice educator confidence in areas related to the on-campus clinic environment, professionalism, student learning, and collaboration. Specifically, clinical practice educator and student confidence were compared through quantitative survey data across multiple cohorts and clinical educators. This data was used to triangulate qualitative findings from focus groups and open-ended survey questions. Analysis across five years of qualitative data revealed themes related to professionalism including time management, planning, feedback, observation, collaboration, and communication. Quantitative data analysis found significant differences between clinical practice educator and student confidence in clinic environment, professionalism, and learning in an on-campus clinic. No significance was found in collaboration. Students were more confident in their familiarity with the on-campus clinic routine than clinical practice educators. Familiarity with the clinic routine was also related to clinical practice educators’ confidence in supporting student learning for growth and change and resolving challenges that impede student learning. Feedback and communication were important in the students\u27 experiences with benefits and suggestions to improve feedback provided by students. Educators and practitioners interested in alternative Level I fieldwork opportunities can consider the implications for a collaborative supervision model in an on-campus clinic environment

Beyond trade: The European Union - New Zealand Free Trade Agreement

The 2022 announcement of the European Union- New Zealand Free Trade Agreement was seminal for both sides. For New Zealand, the deal is projected to be worth up to an extra NZ$1.8 billion per annum by 2035. What is less evident is the motivation for securing the deal for Europe – New Zealand is only the EU’s 50th most important trading partner and accounts for 0.2% of its total trade. This article outlines three major benefits for the EU. Firstly, it symbolises that the EU’s neoliberal trading agenda is continuing in the face of perceived increased protectionism. Second, the deal includes a seminal clause of holding each partner to account in climate change responsibilities – a detail that should garner support from EU citizens. Finally, closer EU cooperation with New Zealand may add to the EU’s legitimacy in the Indo-Pacific

Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons

Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets (PNNs), a specialized extracellular matrix typically localized around inhibitory neurons, also surround mouse CA2 pyramidal neurons and envelop their excitatory synapses. CA2 pyramidal neurons express mRNA transcripts for the major PNN component aggrecan, identifying these neurons as a novel source for PNNs in the hippocampus. We also found that disruption of PNNs allows synaptic potentiation of normally plasticity-resistant excitatory CA2 synapses; thus, PNNs play a role in restricting synaptic plasticity in area CA2. Finally, we found that postnatal development of PNNs on CA2 pyramidal neurons is modified by early-life enrichment, suggesting that the development of circuits containing CA2 excitatory synapses are sensitive to manipulations of the rearing environment

On the formation of glycolaldehyde in dense molecular cores

Glycolaldehyde is a simple monosaccharide sugar linked to prebiotic chemistry. Recently, it was detected in a molecular core in the star-forming region G31.41+0.31 at a reasonably high abundance. We investigate the formation of glycolaldehyde at 10 K to determine whether it can form efficiently under typical dense core conditions. Using an astrochemical model, we test five different reaction mechanisms that have been proposed in the astrophysical literature, finding that a gas-phase formation route is unlikely. Of the grain-surface formation routes, only two are efficient enough at very low temperatures to produce sufficient glycolaldehyde to match the observational estimates, with the mechanism culminating in CH3OH + HCO being favored. However, when we consider the feasibility of these mechanisms from a reaction chemistry perspective, the second grain-surface route looks more promising, H3CO + HCO

Spatiotemporal dynamics of vector-borne disease risk across human land-use gradients: examining the role of agriculture, indigenous territories, and protected areas in Costa Rica

Background Costa Rica has undergone significant changes to its forest ecosystems due, in part, to the proliferation of palm oil and other industrial agriculture operations. However, the country also boasts conservation programmes that are among the most robust in the neotropics. Consequently, gradients of anthropogenic to intact ecosystems are found throughout the country. Forest ecosystems may decrease vector-borne disease (VBD) risk by maintaining insect populations in a state of relative equilibrium; however, evidence suggests that intact forests foster biodiversity and may also amplify VBD risk in some circumstances. As a result, focal points of human-vector contact are likely idiosyncratic. This may be particularly true in indigenous territories, which have been shown to play a vital role in maintaining the ecological integrity of conservation areas. Here, we investigate the relationships between anthropogenic landscapes, indigenous territories, protected areas, and risk of VBD. Methods We quantified spatial dynamics of risk across three distinct categories of VBD in Costa Rica: emerging flaviviruses (Zika virus disease and dengue); neglected tropical diseases (cutaneous leishmaniasis and Chagas disease); and a disease nearing eradication (malaria). We collected district-level incidence data from between 2006 and 2017 and used spatial statistics to identify hotspots of elevated risk. We then quantified the associations between anthropogenic landscapes, intact forest ecosystems, and indigenous territories with both the presence and persistence of elevated transmission risk over time using multivariate hurdle models. Findings We detected clear patterns of non-random disease risk across each of the three categories of VBD. Compared with protected areas, districts with higher proportions of human-altered landscapes, particularly agricultural intensification, were at higher risk for VBD across all categories. Districts with the highest proportion of crop cover, compared with the lowest proportion, were significantly associated with the presence of hotspots for Zika virus disease (OR 15·19 [95% CI 6·19–37·26]), dengue (13·00 [7·24–23·35]), leishmaniasis (4·46 [1·18–16·84]), Chagas disease (3·09 [1·47–6·49]), and malaria (8·40 [3·56–19·83]). Interpretation A set of spatial epidemiology tools within a planetary health framework allowed for a refined understanding of the risk of VBD of global public health significance in a biodiversity hotspot. Our findings may be used to better guide targeted public health disease surveillance, control, and prevention programmes. Additional research to understand the role that socioeconomic factors play in the variating VBD risk would contribute additional context to these findings, as these factors are often also spatially associated

Innovative approaches to investigator-initiated, multicentre paediatric clinical trials in Canada

Data from clinical trials are needed to guide the safe and effective use of medicines in children. Clinical trials are challenging to design and implement in all populations, and children present additional considerations. Several regions including the UK, USA and Europe have established clinical trial infrastructure to capitalise on expertise and promote clinical trials enrolling children. Our objective is to describe the partnerships and operational considerations for the development of paediatric clinical trials infrastructure in Canada. We describe the design and conduct of four emergency room paediatric trials, with four separate sponsors, across four provinces in parallel. Operations discussed include multisite contract development, centralised risk-based data monitoring, ethical review and patient engagement. We conclude with lessons learnt, additional challenges and potential solutions to facilitate drug development for children in Canada

Ionized Gas Extended Over 40 kpc in an Odd Radio Circle Host Galaxy

A new class of extragalactic astronomical sources discovered in 2021, named Odd Radio Circles (ORCs, Norris et al. 2021), are large rings of faint, diffuse radio continuum emission spanning ~1 arcminute on the sky. Galaxies at the centers of several ORCs have photometric redshifts of z~0.3-0.6, implying physical scales of several 100 kiloparsecs in diameter for the radio emission, the origin of which is unknown. Here we report spectroscopic data on an ORC including strong [OII] emission tracing ionized gas in the central galaxy of ORC4 at z=0.4512. The physical extent of the [OII] emission is ~40 kpc in diameter, larger than expected for a typical early-type galaxy (Pandya et al, 2017) but an order of magnitude smaller than the large-scale radio continuum emission. We detect a ~200 km/s velocity gradient across the [OII] nebula, as well as a high velocity dispersion of ~180 km/s. The [OII] equivalent width (EW, ~50 Ang) is extremely high for a quiescent galaxy. The morphology, kinematics, and strength of the [OII] emission are consistent with the infall of shock ionized gas near the galaxy, following a larger-scale, outward moving shock driven by a galactic wind. Both the extended optical and radio emission, while observed on very different scales, may therefore result from the same dramatic event.Comment: 7 figures, accepted to Natur