77 research outputs found
Spreads, arcs, and multiple wavelength codes
AbstractWe present several new families of multiple wavelength (2-dimensional) optical orthogonal codes (2D-OOCs) with ideal auto-correlation λa=0 (codes with at most one pulse per wavelength). We also provide a construction which yields multiple weight codes. All of our constructions produce codes that are either optimal with respect to the Johnson bound (J-optimal), or are asymptotically optimal and maximal. The constructions are based on certain pointsets in finite projective spaces of dimension k over GF(q) denoted PG(k,q)
Coherent matter wave inertial sensors for precision measurements in space
We analyze the advantages of using ultra-cold coherent sources of atoms for
matter-wave interferometry in space. We present a proof-of-principle experiment
that is based on an analysis of the results previously published in [Richard et
al., Phys. Rev. Lett., 91, 010405 (2003)] from which we extract the ratio h/m
for 87Rb. This measurement shows that a limitation in accuracy arises due to
atomic interactions within the Bose-Einstein condensate
WMAP-Compliant Benchmark Surfaces for MSSM Higgs Bosons
We explore `benchmark surfaces' suitable for studying the phenomenology of
Higgs bosons in the minimal supersymmetric extension of the Standard Model
(MSSM), which are chosen so that the supersymmetric relic density is generally
compatible with the range of cold dark matter density preferred by WMAP and
other observations. These benchmark surfaces are specified assuming that
gaugino masses m_{1/2}, soft trilinear supersymmetry-breaking parameters A_0
and the soft supersymmetry-breaking contributions m_0 to the squark and slepton
masses are universal, but not those associated with the Higgs multiplets (the
NUHM framework). The benchmark surfaces may be presented as M_A-tan_beta planes
with fixed or systematically varying values of the other NUHM parameters, such
as m_0, m_{1/2}, A_0 and the Higgs mixing parameter mu. We discuss the
prospects for probing experimentally these benchmark surfaces at the Tevatron
collider, the LHC, the ILC, in B physics and in direct dark-matter detection
experiments. An Appendix documents developments in the FeynHiggs code that
enable the user to explore for her/himself the WMAP-compliant benchmark
surfaces.Comment: Minor corrections, references added. 43 pages, 10 figures. Version to
appear in JHE
A method to estimate climate-critical construction materials applied to seaport protection
Ancillary techniques on the evaluation of canine cutaneous mast cell tumors from Brazil
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets. © 2022. The Author(s). Published by the American Astronomical Society
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters
A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known to be associated with lung cancer risk, promotes lung cancer by acting on cells that harbour pre-existing oncogenic mutations in healthy lung tissue. Focusing on EGFR-driven lung cancer, which is more common in never-smokers or light smokers, we found a significant association between PM2.5 levels and the incidence of lung cancer for 32,957 EGFR-driven lung cancer cases in four within-country cohorts. Functional mouse models revealed that air pollutants cause an influx of macrophages into the lung and release of interleukin-1β. This process results in a progenitor-like cell state within EGFR mutant lung alveolar type II epithelial cells that fuels tumorigenesis. Ultradeep mutational profiling of histologically normal lung tissue from 295 individuals across 3 clinical cohorts revealed oncogenic EGFR and KRAS driver mutations in 18% and 53% of healthy tissue samples, respectively. These findings collectively support a tumour-promoting role for PM2.5 air pollutants and provide impetus for public health policy initiatives to address air pollution to reduce disease burden
Transferable atoms: an intra-atomic perspective through the study of homogeneous oligopeptides
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