Relationship of Circulating Ghrelin and Leptin Concentrations in Beef Cattle ExhibitingDifferences in Composition of Gain

Beef steers (n = 72) of similar age, weight (651 ± 3.1 lb), and genetic background (Angus crossbred) were used to determine the effects of growing period diet on the relationship of plasma ghrelin and leptin concentrations with growth performance and carcass composition. At trial initiation (d 0), 8 steers were harvested for initial carcass composition. The remaining 64 steers were allotted, by weight, to pen and treatment was assigned randomly. Treatments were 1) a high‐forage diet fed during the growing period (0‐116 d) followed by a high‐concentrate diet during the finishing period (117‐209 d; GRW‐FNSH) or 2) a high‐concentrate diet fed for the duration of the trial (0‐209 d; FNSH‐FNSH). Steers were allowed ad libitum consumption regardless of dietary treatment. Eight steers per treatment (1 pen) were harvested on d 88, 116, 165, and 209. At each harvest date, 9‐10‐11th rib sections were dissected for chemical composition, and carcass characteristics were recorded. Replicate blood samples were collected from every steer prior to each harvest, and assayed for ghrelin, leptin, GH, insulin, and NEFA concentrations. Hormone, growth performance, and carcass composition were analyzed statistically using the GLM procedure of SAS to evaluate diet, harvest date, and their interaction. Linear, quadratic, and cubic contrasts were performed. Percent carcass protein decreased linearly (P \u3c 0.001) and percent carcass fat increased linearly (P \u3c 0.001) in both treatments. At each harvest day, FNSH‐FNSH steers had greater carcass fat (P \u3c 0.01) compared with GRW‐FNSH steers. Plasma ghrelin concentrations for FNSH‐FNSH increased quadraticly (P \u3c 0.001) over time, whereas plasma ghrelin concentrations were not different over time for GRW‐FNSH. Plasma leptin concentrations for FNSH‐FNSH increased (P \u3c 0.001) from d 0 to 88 and then plateaued, whereas plasma leptin concentrations increased linearly (P \u3c 0.001) for the GRW‐FNSH. Plasma ghrelin and leptin concentrations fluctuated relative to nutritional status, and plasma ghrelin concentrations were highest in excessively fat cattle. The role of ghrelin during fat accumulation warrants further investigation

Post-weaning Nutritional Programming of Ovarian Developmentin Beef Heifers

The nutritional management of replacement females from weaning to breeding is critical to lifetime productivity. Traditionally, cereal grains have been used to develop replacement heifers to attain puberty and enter the breeding system at a younger age. However, overfeeding heifers decreases number of calves weaned, while peri-pubertal caloric restriction increased primordial follicle numbers in the developing ovary. The number of primordial follicles a female has can determine her overall fertility; females with a greater amount of follicles have greater reproductive lifespans. In this study, two groups of heifers were developed to prebreeding status. One group received a control diet (228 kcal ME/BW kg0.75) while the other received a restricted diet (157 kcal ME/BW kg0.75) for 84 days, and were then stepped up to receive a diet containing 277 kcal ME/BW kg0.75. Both groups were evaluated at three different time points for number of primordial follicles. Heifers on the restricted diet had more primordial follicles than control heifers at 13 mo of age. In summary, heifer input costs could be decreased without negatively effecting overall fertility and perhaps improve fertility

Running Spectral Index and Formation of Primordial Black Hole in Single Field Inflation Models

A broad range of single field models of inflation are analyzed in light of all relevant recent cosmological data, checking whether they can lead to the formation of long-lived Primordial Black Holes (PBHs). To that end we calculate the spectral index of the power spectrum of primordial perturbations as well as its first and second derivatives. PBH formation is possible only if the spectral index increases significantly at small scales, i.e. large wave number $k$. Since current data indicate that the first derivative $\alpha_S$ of the spectral index $n_S(k_0)$ is negative at the pivot scale $k_0$, PBH formation is only possible in the presence of a sizable and positive second derivative ("running of the running") $\beta_S$. Among the three small-field and five large-field models we analyze, only one small-field model, the "running mass" model, allows PBH formation, for a narrow range of parameters. We also note that none of the models we analyze can accord for a large and negative value of $\alpha_S$, which is weakly preferred by current data.Comment: 26 pages, 5 figures, Refs. added, Minor textual change; version to appear in JCA

Non-Gaussian isocurvature perturbations in dark radiation

We study non-Gaussian properties of the isocurvature perturbations in the dark radiation, which consists of the active neutrinos and extra light species, if exist. We first derive expressions for the bispectra of primordial perturbations which are mixtures of curvature and dark radiation isocurvature perturbations. We also discuss CMB bispectra produced in our model and forecast CMB constraints on the nonlinearity parameters based on the Fisher matrix analysis. Some concrete particle physics motivated models are presented in which large isocurvature perturbations in extra light species and/or the neutrino density isocurvature perturbations as well as their non-Gaussianities may be generated. Thus detections of non-Gaussianity in the dark radiation isocurvature perturbation will give us an opportunity to identify the origin of extra light species and lepton asymmetry.Comment: 32 pages, 7 figure

Isocurvature perturbations in extra radiation

Recent cosmological observations, including measurements of the CMB anisotropy and the primordial helium abundance, indicate the existence of an extra radiation component in the Universe beyond the standard three neutrino species. In this paper we explore the possibility that the extra radiation has isocurvatrue fluctuations. A general formalism to evaluate isocurvature perturbations in the extra radiation is provided in the mixed inflaton-curvaton system, where the extra radiation is produced by the decay of both scalar fields. We also derive constraints on the abundance of the extra radiation and the amount of its isocurvature perturbation. Current observational data favors the existence of an extra radiation component, but does not indicate its having isocurvature perturbation. These constraints are applied to some particle physics motivated models. If future observations detect isocurvature perturbations in the extra radiation, it will give us a hint to the origin of the extra radiation.Comment: 41 pages, 8 figures; version accepted for publication in JCA

Issues Concerning Loop Corrections to the Primordial Power Spectra

We expound ten principles in an attempt to clarify the debate over infrared loop corrections to the primordial scalar and tensor power spectra from inflation. Among other things we note that existing proposals for nonlinear extensions of the scalar fluctuation field $\zeta$ introduce new ultraviolet divergences which no one understands how to renormalize. Loop corrections and higher correlators of these putative observables would also be enhanced by inverse powers of the slow roll parameter $\epsilon$. We propose an extension which should be better behaved.Comment: 36 pages, uses LaTeX2e, version 3 revised for publication with a much expanded section 4, proving that our proposed extension of the zeta-zeta correlator absorbs the one loop infrared divergences from graviton