168 research outputs found

    Sharpenings of Li's criterion for the Riemann Hypothesis

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    Exact and asymptotic formulae are displayed for the coefficients λn\lambda_n used in Li's criterion for the Riemann Hypothesis. For nn \to \infty we obtain that if (and only if) the Hypothesis is true, λnn(Alogn+B)\lambda_n \sim n(A \log n +B) (with A>0A>0 and BB explicitly given, also for the case of more general zeta or LL-functions); whereas in the opposite case, λn\lambda_n has a non-tempered oscillatory form.Comment: 10 pages, Math. Phys. Anal. Geom (2006, at press). V2: minor text corrections and updated reference

    Cell-Specific Monitoring of Protein Synthesis In Vivo

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    Analysis of general and specific protein synthesis provides important information, relevant to cellular physiology and function. However, existing methodologies, involving metabolic labelling by incorporation of radioactive amino acids into nascent polypeptides, cannot be applied to monitor protein synthesis in specific cells or tissues, in live specimens. We have developed a novel approach for monitoring protein synthesis in specific cells or tissues, in vivo. Fluorescent reporter proteins such as GFP are expressed in specific cells and tissues of interest or throughout animals using appropriate promoters. Protein synthesis rates are assessed by following fluorescence recovery after partial photobleaching of the fluorophore at targeted sites. We evaluate the method by examining protein synthesis rates in diverse cell types of live, wild type or mRNA translation-defective Caenorhabditis elegans animals. Because it is non-invasive, our approach allows monitoring of protein synthesis in single cells or tissues with intrinsically different protein synthesis rates. Furthermore, it can be readily implemented in other organisms or cell culture systems

    A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres

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    Background: Pyrenophora teres f. teres is a necrotrophic fungal pathogen and the cause of one of barley’s most important diseases, net form of net blotch. Here we report the first genome assembly for this species based solely on short Solexa sequencing reads of isolate 0-1. The assembly was validated by comparison to BAC sequences, ESTs, orthologous genes and by PCR, and complemented by cytogenetic karyotyping and the first genome-wide genetic map for P. teres f. teres. Results: The total assembly was 41.95 Mbp and contains 11,799 gene models of 50 amino acids or more. Comparison against two sequenced BACs showed that complex regions with a high GC content assembled effectively. Electrophoretic karyotyping showed distinct chromosomal polymorphisms between isolates 0-1 and 15A, and cytological karyotyping confirmed the presence of at least nine chromosomes. The genetic map spans 2477.7 cM and is composed of 243 markers in 25 linkage groups, and incorporates SSR markers developed from the assembly. Among predicted genes, non-ribosomal peptide synthetases and efflux pumps in particular appear to have undergone a P. teres f. teres-specific expansion of non-orthologous gene families. Conclusions: This study demonstrates that paired-end Solexa sequencing can successfully capture coding regions of a filamentous fungal genome. The assembly contains a plethora of predicted genes that have been implicated in a necrotrophic lifestyle and pathogenicity and presents a significant resource for examining the bases for P. teres f. teres pathogenicity

    Seed Planter.

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    Patent for the improvement of the seed-box so the seeds are properly distributed into the soil while preventing the seed from clogging the machine, including illustration

    Geschlechtersensible Beratung. Traditionslinien und praktische Ansätze

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    Keiper U, Kleine M. Geschlechtersensible Beratung. Traditionslinien und praktische Ansätze. In: Gröning K, Kunstmann A-C, Neumann C, eds. Geschlechtersensible Beratung. Traditionslinien und praktische Ansätze. 2015: 223-238

    Pedagogical Innovations For the Millennial Sport Management Student: Socrative and Twitter

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    © 2017 North American Society for Sport Management. Pedagogical innovation involving smartphone technology paired with complementary applications may offer sport management faculty the opportunity to create an environment of engaging instruction. Technologically enhanced and innovative assignments have the potential to stimulate student interest and critical-thinking skills by presenting new experiences and active learning opportunities via participatory education. Through the discussion of technology integration and pedagogical innovation when teaching millennial students, the purpose of this paper is to provide a conceptual framework-namely, the concerns-based adoption model (CBAM)-to introduce mobile technologies, such as Socrative and Twitter, into the sport management classroom
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