Event-based computer simulation model of Aspect-type experiments strictly satisfying Einstein's locality conditions

Inspired by Einstein-Podolsky-Rosen-Bohm experiments with photons, we construct an event-based simulation model in which every essential element in the ideal experiment has a counterpart. The model satisfies Einstein's criteria of local causality and does not rely on concepts of quantum and probability theory. We consider experiments in which the averages correspond to those of a singlet and product state of a system of two $S=1/2$ particles. The data is analyzed according to the experimental procedure, employing a time window to identify pairs. We study how the time window and the passage time of the photons, which depends on the relative angle between their polarization and the polarizer's direction, influences the correlations, demonstrating that the properties of the optical elements in the observation stations affect the correlations although the stations are separated spatially and temporarily. We show that the model can reproduce results which are considered to be intrinsically quantum mechanical

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding

Peer reviewedPublisher PD

Reply to Comment on "A local realist model for correlations of the singlet state"

The general conclusion of Seevinck and Larsson is that our model exploits the so-called coincidence-time loophole and produces sinusoidal (quantum-like) correlations but does not model the singlet state because it does not violate the relevant Bell inequality derived by Larsson and Gill, since in order to obtain the sinusoidal correlations the probability of coincidences in our model goes to zero. In this reply, we refute their arguments that lead to this conclusion and demonstrate that our model can reproduce results of photon and ion-trap experiments with frequencies of coincidences that are not in conflict with the observations.Comment: Corrected typo

Everolimus and long acting octreotide as a volume reducing treatment of polycystic livers (ELATE): study protocol for a randomized controlled trial

Contains fulltext : 97893.pdf (publisher's version ) (Open Access)ABSTRACT: BACKGROUND: Polycystic liver disease (PLD) is defined as having more than 20 liver cysts and can present as a severe and disabling condition. Most symptoms are caused by the mass effect of the liver size and include abdominal pain and distension. The somatostatin analogues octreotide and lanreotide have proven to reduce polycystic liver volume. mTOR inhibitors such as everolimus inhibit cell proliferation and might thereby reduce growth of liver cysts. This trial aims to assess the benefit of combination therapy of everolimus and octreotide compared to octreotide monotherapy. In this study we present the structure of the trial and the characteristics of the included patients. METHODS/DESIGN: This is a randomized open-label clinical trial comparing the effect of 12 months of everolimus and octreotide to octreotide monotherapy in PLD patients. Primary outcome is change in liver volume determined by CT-volumetry. Secondary outcomes are changes in abdominal symptoms and quality of life. Moreover, safety and tolerability of the drugs will be assessed. DISCUSSION: This trial will compare the relative efficacy of combination therapy with octreotide and everolimus to octreotide monotherapy. Since they apply to different pathways of cystogenesis we expect that combining octreotide and everolimus will result in a cumulative reduction of polycystic liver volume. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT01157858