Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

Rs in cardiogenesis remain unclear.Rs mimicked the phenotype of the AV valve defect that result from the inhibition of calcineurin, and it could be rescued by constitutively active calcineurin.Rs in cardiogenesis in part through the regulation of calcineurin-NFAT signaling

Shortening of intraventricular conduction time with rapid ventricular pacing

Background: Supernormal conduction (SNC) of the human ventricular myocardium has been reported, but its mechanism remains controversial. Methods: We recorded monophasic action potentials during rapid ventricular pacing from the right ventricular endocardium in 24 patients with supraventricular tachyarrhythmias who underwent catheter ablation. Results: In 7 of 24 patients, shortening of the QRS duration was observed at a pacing cycle length ≤400 ms and lengthening of the QRS duration was observed in 3. Conclusions: Shortening of the QRS duration during rapid ventricular pacing was observed in the patients

Analysis of the spatial and transmural dispersion of repolarization and late potentials derived using signal-averaged vector-projected 187-channel high-resolution electrocardiogram in patients with early repolarization pattern

Background: Electrophysiological characteristics of early repolarization syndrome (ERS), i.e., the spatial and transmural dispersion of ventricular repolarization and ventricular late potentials can be evaluated using a signal-averaged vector-projected 187-channel high-resolution electrocardiogram (187-ch SAVP-ECG). We investigated these characteristics as markers of ventricular fibrillation and sudden cardiac arrest in patients presenting with an ER pattern. Methods: The 187-ch SAVP-ECGs were recorded for 8 patients with idiopathic ventricular fibrillation associated with ERS (ERS patients), and 5 patients with an ER pattern without arrhythmic events (ER pattern patients). Results: The ER pattern was located in the inferior leads (n=7), lateral leads (n=1), or both inferior and lateral leads (n=5). The corrected RT(RTc) (peak point of the R wave − positive maximum peak of the first derivative of the T wave interval corrected using the Bazett formula) interval and T(peak-end)-c interval from the 187 channels were calculated. Late potentials were positive in 7 of 8 ERS patients and in 3 of 5ER pattern patients (P=0.25). The average RTc was shorter in patients with ERS (192.6±29.8 ms vs. 234.0±25.5 ms, P=0.04). However, average T(peak-end)-c interval did not differ between the 2 groups. Conclusion: Late ventricular potentials were common in ERS and ER pattern patients. Lethal arrhythmia in ERS patients appeared to be related to the relatively short average repolarization time rather than the spatial and transmural dispersion of repolarization

A case of cardiac sarcoidosis presenting with double tachycardia

Although the most feared cardiac manifestation in cardiac sarcoidosis is the onset of ventricular arrhythmia, some patients may present with supraventricular arrhythmias. We present a rare case of cardiac sarcoidosis associated with double tachycardia manifesting as atrial flutter and ventricular tachycardia

Wavefront direction and cycle length affect left atrial electrogram amplitude

Background: The relationship between atrial electrogram (EGM) characteristics in atrial fibrillation (AF) and those in sinus rhythm (SR) are generally unknown. The activation rate and direction may affect EGM characteristics. We examined characteristics of left atrial (LA) EGMs obtained during pacing from different sites. Methods: The study included 10 patients undergoing pulmonary vein isolation for AF. Atrial EGMs were recorded from a 64-pole basket catheter placed in the LA, and bipolar EGM amplitudes from the distal electrode pair (1–2) and proximal electrode pair (6–7) from 8 splines were averaged. The high right atrium (HRA), proximal coronary sinus (CSp), and distal coronary sinus (CSd) were paced at 600 ms and 300 ms. Results: When the LA voltage at SR was ≥1.5 mV, bipolar voltages of the HRA were greater than those of the CSp, which were greater than those of the CSd, regardless of the pacing cycle length. The shorter pacing cycle length resulted in a reduction of the LA EGM voltage at sites of SR voltage ≥1.5 mV, but no significant difference was seen at sites where the SR EGM amplitude was between >0.5 and <1.5 mV. No significant differences were seen in intra-basket conduction times between pacing cycle lengths of 600 ms and 300 ms at any pacing site. Conclusion: The rate and direction-dependent reduction of the amplitude of atrial EGMs may explain, in part, the voltage discordance during SR and AF

Monophasic action potential duration alternans after abrupt shortening of the cardiac cycle in humans

Background: Action potential alternans may be important in causing ventricular arrhythmias. Methods and results: We recorded monophasic action potentials from the right ventricular endocardium in patients with persistent atrial fibrillation who underwent internal atrial defibrillation during rapid ventricular pacing. In 3 of 45 patients, monophasic action potential duration alternans was observed at a pacing cycle length ≤350 ms. Conclusion: Action potential alternans is not a rare phenomenon (6.6%) in humans

Left atrial remodeling: Regional differences between paroxysmal and persistent atrial fibrillation

Background: The mechanisms underlying self-perpetuation of persistent atrial fibrillation (AF) are not well understood. To gain insight into these mechanisms, we conducted a study comparing left atrial (LA) electroanatomic maps obtained during sinus rhythm between patients with paroxysmal AF (PAF) and patients with persistent AF (PerAF). Methods: The study included 23 men with PAF (age, 56.3±12.1 years) and 13 men with PerAF (age, 54.3±13.4 years). LA voltage mapping was performed during sinus rhythm. The clinical and electroanatomic characteristics of the two groups were evaluated and analyzed statistically. Results: The bipolar voltages at the LA septum, roof, and posterior wall, right superior pulmonary vein (PV) and its antrum, right superior PV carina, and right inferior PV antrum were significantly lower in patients with PerAF than in those with PAF. The bipolar voltages in other parts of the LA did not differ statistically between the two groups. Conclusion: PAF and PerAF seem to be characterized by differences in the regional voltage in the LA and PVs. The LA structural remodeling of PerAF may initiate from the right PVs and their antra and LA septum, roof, and posterior wall

Clinical implications of serum adiponectin on progression of atrial fibrillation

Background: The association between circulating adiponectin levels and atrial fibrillation (AF) is uncertain. We, therefore, investigated whether an increased serum adiponectin level is implicated in the long-term recurrence of AF after ablation therapy. Methods: Our study included 100 consecutive patients (88 men; median age, 57.9±10.9 years) who underwent catheter ablation for AF at our hospital between 2011 and 2013. The adiponectin and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured before ablation and compared between those in whom AF recurred and those in whom AF did not recur. Results: Elevation in adiponectin levels was significantly associated with female sex, non-paroxysmal AF, heart failure, higher NT-proBNP and matrix metallo-proteinase-2 levels, and lower body mass index. After a stepwise adjustment for any potential confounding variables, the adiponectin levels remained significantly associated with female sex (beta=0.2601, P=0.0041), non-paroxysmal AF (beta=0.2708, P=0.0080), and higher NT-proBNP levels (beta=0.2536, P= 0.0138). During the median follow-up period of 26.2 months, AF recurred in 48 of the 100 patients. Stepwise multivariate adjustment showed that an increased log-transformed NT-proBNP (Hazard ratio [HR], 2.18; 95% confidence interval [CI] 1.25â4.00; P=0.0055), longer duration of AF (HR, 1.87; 95%CI 1.01â3.76; P=0.0465), and decreased left ventricular ejection fraction (HR, 0.96; 95%CI 0.93â0.99; P=0.0391) were independent predictors of recurrent AF after catheter ablation, but adiponectin was not. Conclusions: Our data indicated that adiponectin was partially responsible for progression of AF, but the correlation between adiponectin levels and AF recurrence was not significant. Keywords: Atrial fibrillation, Adiponectin, NT-proBNP, Ablatio