Cardiomyopathy: Recent Findings

In 1957, Wallace Brigden published an article on the Lancet, such as uncommon myocardial diseases: the non-coronary cardiomyopathy. In this article, he mentioned that “the term cardiomyopathy is used here to indicate isolated noncoronary myocardial disease.” Then “cardiomyopathy” has become a commonly used term in the cardiovascular field, and has been defined and classified by many researchers and academic societies. The basic concept of cardiomyopathy is a group of diseases with mechanical and/or electrophysiological dysfunction of the ventricles, and cardiomyopathy is distinguished with normal ischemic heart disease, valvular disease, and hypertensive heart disease. It can often cause heart failure and cardiac death. In this chapter, we describe the classification, details, and treatment of cardiomyopathy, and iPS cell from pathological myocardium

サリチル酸中毒に関する研究(第II報) : サリチル酸長期投与ラットの病理学的研究

Intoxication of salicylic acid was experimented on Wister rats. The salicylic acid that dissolved in drinking water was administered to rats for 98 weeks. The experimental groups were administered each of salicylic acid solution in 0.025% (1st group), 0.1% (2nd group), 0.2% (3rd group). Part I (Takagi et al, 1973) reported on hematological, serological and biochemical approaches to this problem. The present paper is concerned with the gross anatomical and histopathological examination. Gross anatomically in lungs of half of the rats lesion by neoplasma was observed but no remarkable chenges in other organs. Histopathological examinations were as follows. ln most livers of the rats increased kuppffer\u27s cells, Inlarged sinusoid, affected nucleus in liver cells were seen. Half of the rats showed slight lipoid metamorphosis in spongiocytes of adrenal glands and some chenges in other organs

サリチル酸中毒に関する研究(第I報) : サリチル酸長期投与ラットの臨床的観察

In this thesis we treat with the clinical effects of chronic toxicity in Wistar rats by 98-week oral administration experiments with salicylic acid. The results were as follows : (1) Inhibition of increase of body weight was observed in administered groups, especially in 0.1% level of salicylic acid. (2) A high incidence of tumors in lung, skin and lymphatic vessel was found in administered groups. (3) Effects of salicylic acid on the count of erythrocyte and leucocyte, and concentration of hemoglobin were not observed