TGF - ベータ1 Transforming growth factor ガンシン コラーゲン スポンジ オ モチイタ ガッコツ ノ サイセイ シュウフク

京都大学0048新制・論文博士博士(医学)乙第11289号論医博第1834号新制||医||843(附属図書館)UT51-2003-N938(主査)教授 開 祐司, 教授 飯塚 忠彦, 教授 清水 慶彦学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDA

Changes in average nasal skin temperature after left cervical sympathetic ganglion block (CSGB).

<p>There was a significant increase in average nasal skin temperature after CSGB, which lasted for 10 weeks on the left side and 3 weeks on the right side. Values are expressed as mean ± SD. *P < 0.01 in comparison with the baseline value.</p

Gross images of regenerated inferior alveolar nerve in the reconstruction (A) and cervical sympathetic ganglion block (B) groups.

<p>Nerve regeneration (region between white arrowheads) was observed in both groups.</p

Semi-thin transverse sections (A–C; toluidine blue staining) and transmission electron microscopy images (D–F) of the regenerated inferior alveolar nerve (IAN) at 3 months post-reconstruction.

<p>Distal segments of the regenerated left IAN in the reconstruction-only (A, D) and reconstruction + cervical sympathetic ganglion block (reconstruction+CSGB; B, E) groups. (C, F) Central segment of the right IAN in the reconstruction-only group (normal control). Black and white arrowheads indicate myelinated and non-myelinated nerve fibers, respectively. Scale bars, 50 μm (A–C) and 5 μm (D–F).</p

Gross image (A) and scanning electron micrograph (B) of a polyglycolic acid tube filled with collagen sponge.

<p>Gross image (A) and scanning electron micrograph (B) of a polyglycolic acid tube filled with collagen sponge.</p

Light microscopy images of hematoxylin–eosin-stained transverse sections of the left (A) and right (B) cervical sympathetic ganglia at 6 months after ethanol injection.

<p>While the left side exhibited no ganglion cells in the entire ganglion, the right side exhibited ganglion cells throughout the ganglion. Scale bars, 50 μm.</p

Electrophysiological findings in the IAN at 3 months after surgery.

<p>Electrophysiological findings in the IAN at 3 months after surgery.</p

Percent changes in oral mucosal blood flow in the left mental region after cervical sympathetic ganglion block (CSGB).

<p>Blood flow was measured in the region dominated by the left mental arterial branch. The proportion of oral mucosal blood flow on the left side after CSGB remained significantly higher than that at baseline for up to 7 weeks. Values are expressed as mean ± standard deviation; *P < 0.01 in comparison with the baseline value.</p

Can nerve regeneration on an artificial nerve conduit be enhanced by ethanol-induced cervical sympathetic ganglion block? - Fig 4

<p>(A) Thermogram acquired before left cervical sympathetic ganglion block (CSGB) by ethanol injection. There was no difference in bilateral skin temperature. (B) A week after left CSGB, skin temperature on the left side was significantly higher compared to the baseline value.</p

Immunohistochemistry images of distal segments of the regenerated left inferior alveolar nerve at 3 months post-reconstruction (neurofilament and S100 staining).

<p>(A, C) reconstruction-only group; (B, D) reconstruction + cervical sympathetic ganglion block (CSGB) group. Black arrowheads indicate regenerated axons. White arrowheads indicate Schwann cells. Scale bars, 50 μm.</p