自発的ドック受診者群と企業健診受診者群の脳MRIにおけるT2高信号域個数の比較

he purpose of this study was to evaluate the difference in T2-elongated spots (T2ES) between self-referred and third party-referred subjects.The brain MRI studies of 814 healthy adults were assessed. The subjects were categorized into two groups. Group A included 312 self-referred subjects ranging in age from 49 to 65 years (mean age, 56.5 years). Group B included 502 third party-referred subjects same ranging in age (mean age, 54.3 years). All subjects were asked to complete an interview sheet dealing with current and past diseases. To compare the two groups, an ‘Age-related Grading System\u27 was created.Grade 4 was defined as including patients who had 10 to 14 more T2ESs than their age minus 49; 20.027771275620f Group B and 13.51111400240f Group A (P<0.05) were classified as Grade 4. Diabetes mellitus was present in 15.016010062550f Group A and 9.615734071165f Group B (P<0.05). Hyperlipidemia was present in 18.015710062563f Group A and 9.015035020146f Group B (P<0.01).Although diabetes mellitus and hyperlipidemia were more common in Group A, these diseases were considered to be well controlled. It would appear that the patients in Group A were more health conscious than those in Group B

Additional file 1: Figure S1. of Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs

Within-pair differences for the methylation levels (WPDMs) of each CpG island. Red circles indicate male pairs, and blue circles indicate female pairs. Within-pair differences in male pairs are greater in most autosomal CpG islands. (TIF 2145 kb

Additional file 3: Figure S2. of Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs

Comparison of within-pair differences in methylation levels (WPDMs) between older male and older female pairs. The gender difference index is positive when the mean within-pair differences in the methylation levels are higher in male pairs than female pairs. (TIF 298 kb

Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study

<div><p>Whereas most of studies investigating relationship between oral health and atherosclerosis have focused on periodontitis, very few of them were examined about occlusal status of natural teeth which possibly influence dietary habit. The primary aim of this cross-sectional study was to investigate the association between the occlusal support of posterior teeth and the prevalence of atherosclerosis in community-dwelling septuagenarians. Also, the second aim was to test the hypothesis that the intake of key nutrients for atherosclerosis prevention would have a mediating effect on the relationship between the occlusal status and atherosclerosis. The study population included 468 community-dwelling dentate persons aged 69–71 years recruited from the local residential registration in Japan. Participants were divided into three groups, according to the number of occlusal support zones (OSZ) in the posterior area: Complete (four OSZ), Moderate (three or two OSZ), and Collapsed (one or no OSZ). Dietary intakes were assessed using a brief-type self-administered diet history questionnaire. Atherosclerosis was defined as carotid intima-media thickness ≧1.10 mm by using carotid ultrasonography test. The logistic or linear regression model was used in multivariate analysis to assess relationship between occlusal status and atherosclerosis, and the mediating effect of key nutrients within the relationship. Multivariable analysis showed a significant association between occlusal status and atherosclerosis (odds ratio for Collapsed group to Complete group: 1.87; 95% CI: 1.45–2.41), independent of periodontal status (odds ratio: 2.01, 95%CI: 1.46–2.78). Fish and shellfish, vitamin B6 and n-3PUFAs were significantly related to both of occlusal status and atherosclerosis, and also was indicated a mediating effect on the association between occlusal status and atherosclerosis. This study implied that, within the limitation of the cross-sectional study design, the reduced posterior occlusion was related to the increased prevalence of atherosclerosis via the decline of key dietary intakes among Japanese community-dwelling dentate individuals.</p></div

Demographic and clinical characteristics of the group A by prevalence of atherosclerosis.

<p>Demographic and clinical characteristics of the group A by prevalence of atherosclerosis.</p

Odds ratio of occlusal status towards atherosclerosis assessing the effect of fish and shellfish, vitamin B6 and n-3PUFAs.

<p>CI: Confidence Interval, OR: Odds Ratio, n-3PUFAs: n-3 polyunsaturated fatty acid, Model*: adjusting for periodontal disease, gender, region of residence, smoking habits, drinking habits, education level, diabetes mellitus, hypertension, dyslipidemia, and hyperuricemia., Model**: Model* + (Fish & Shellfish), Model***: Model* + (Vitamin B6), Model****: Model* + (n-3PUFAs).</p

Demographic and clinical characteristics of the group B by prevalence of atherosclerosis.

<p>Demographic and clinical characteristics of the group B by prevalence of atherosclerosis.</p

Relationship of each key food or nutrient to atherosclerosis and to occlusal support, adjusted for covariates.

<p>Relationship of each key food or nutrient to atherosclerosis and to occlusal support, adjusted for covariates.</p

Unadjusted association between key food or nutrient intakes and occlusal support.

<p>Unadjusted association between key food or nutrient intakes and occlusal support.</p

Odds ratios of main variables with adjustment for periodontal disease.

<p>Odds ratios of main variables with adjustment for periodontal disease.</p