From Being Known in the Classroom to “Moments of Meeting”: What Intersubjectivity offers Contemplative Pedagogy

Despite recent advances in psychological theory and research, often empirical knowledge of intersubjectivity is not incorporated into teaching. In this paper we suggest that using the intersubjective space of the classroom can provide students with experiences of being known and “moments of meeting” which can result in transformative learning. Using a conceptual framework, we explore why being known is a relevant concept in education and contemplative pedagogy, and highlight student perspectives and an example from our own teaching. We suggest that contemplative pedagogical activities are inherently intersubjective, thereby providing opportunities for being known and educational moments of meeting

The Grizzly, February 27, 1981

Police Involvement: Fraternity Pledging Marred by Bad Reports • Lewis Thomas Graduation Speaker • FCA Gearing Up for Special Olympics • Off-Campus Housing Explored by USGA • USGA Notes • Wickersham Outlines Fall Semester Senior Symposium • Departmental Focus: Romance Languages • Middle East: Soviet Rivalry Topic of Forum • Beta Sig to Sponsor Franken & Davis • Cafe International Opens Tonight • Bierprobe Taste-Testing a Big Success • Reborn Songfest Loses Appeal • IFC Dance Slated for March 20 • You See UC to Become Regular Friday Feature • Registration Delayed • Gifford Heading for Nationals • Lady Swimmers End Season at .500 • Basketball Shooting for NCAA Tournament • Aquabears Have High Hopes for MACs • Sweeney, DiMattia Take 1sts in Indoor Track • Women Hoopsters Enter Playoffs Looking for Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1054/thumbnail.jp

UV Absorption Lines from High-Velocity Gas in the Vela Supernova Remnant: New insights from STIS Echelle Observations of HD72089

The star HD72089 is located behind the Vela supernova remnant and shows a complex array of high and low velocity interstellar absorption features arising from shocked clouds. A spectrum of this star was recorded over the wavelength range 1196.4 to 1397.2 Angstroms at a resolving power lambda/Delta lambda = 110,000 and signal-to-noise ratio of 32 by STIS on the Hubble Space Telescope. We have identified 7 narrow components of C I and have measured their relative populations in excited fine-structure levels. Broader features at heliocentric velocities ranging from -70 to +130 km/s are seen in C II, N I, O I, Si II, S II and Ni II. In the high-velocity components, the unusually low abundances of N I and O I, relative to S II and Si II, suggest that these elements may be preferentially ionized to higher stages by radiation from hot gas immediately behind the shock fronts.Comment: 11 pages, 2 figures, Latex. Submitted for the special HST ERO issue of the Astrophysical Journal Letter

The architecture of EMC reveals a path for membrane protein insertion.

Funder: Boehringer Ingelheim Fonds; FundRef: http://dx.doi.org/10.13039/501100001645Funder: Naito Foundation; FundRef: http://dx.doi.org/10.13039/100007428Funder: Japanese Biochemical SocietyApproximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of individual subunits, site-specific photocrosslinking, and cryo-EM reconstruction. Our results suggest that EMC's cytosolic domain contains a large, moderately hydrophobic vestibule that can bind a substrate's transmembrane domain (TMD). The cytosolic vestibule leads into a lumenally-sealed, lipid-exposed intramembrane groove large enough to accommodate a single substrate TMD. A gap between the cytosolic vestibule and intramembrane groove provides a potential path for substrate egress from EMC. These findings suggest how EMC facilitates energy-independent membrane insertion of TMDs, explain why only short lumenal domains are translocated by EMC, and constrain models of EMC's proposed chaperone function

The architecture of EMC reveals a path for membrane protein insertion

Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of individual subunits, site-specific photocrosslinking, and cryo-EM reconstruction. Our results suggest that EMC’s cytosolic domain contains a large, moderately hydrophobic vestibule that can bind a substrate’s transmembrane domain (TMD). The cytosolic vestibule leads into a lumenally-sealed, lipid-exposed intramembrane groove large enough to accommodate a single substrate TMD. A gap between the cytosolic vestibule and intramembrane groove provides a potential path for substrate egress from EMC. These findings suggest how EMC facilitates energy-independent membrane insertion of TMDs, explain why only short lumenal domains are translocated by EMC, and constrain models of EMC’s proposed chaperone function

The architecture of EMC reveals a path for membrane protein insertion

Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of individual subunits, site-specific photocrosslinking, and cryo-EM reconstruction. Our results suggest that EMC’s cytosolic domain contains a large, moderately hydrophobic vestibule that can bind a substrate’s transmembrane domain (TMD). The cytosolic vestibule leads into a lumenally-sealed, lipid-exposed intramembrane groove large enough to accommodate a single substrate TMD. A gap between the cytosolic vestibule and intramembrane groove provides a potential path for substrate egress from EMC. These findings suggest how EMC facilitates energy-independent membrane insertion of TMDs, explain why only short lumenal domains are translocated by EMC, and constrain models of EMC’s proposed chaperone function

The architecture of EMC reveals a path for membrane protein insertion

Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of individual subunits, site-specific photocrosslinking, and cryo-EM reconstruction. Our results suggest that EMC’s cytosolic domain contains a large, moderately hydrophobic vestibule that can bind a substrate’s transmembrane domain (TMD). The cytosolic vestibule leads into a lumenally-sealed, lipid-exposed intramembrane groove large enough to accommodate a single substrate TMD. A gap between the cytosolic vestibule and intramembrane groove provides a potential path for substrate egress from EMC. These findings suggest how EMC facilitates energy-independent membrane insertion of TMDs, explain why only short lumenal domains are translocated by EMC, and constrain models of EMC’s proposed chaperone function

The Grizzly, December 5, 1980

Work Study Pay Increased To Minimum Wage • Chemistry Department Victimized by Malicious Pranks • Holiday Vacation Marred By Campus Break-ins • Richter Outlines Campus Concerns • Petition Shows Strong Support for Greaseband Return • Alumni Committee for Pre-Med Consultation • Wismer Corner • 1980 at Ursinus: The Year in Review • Southern Bands \u27Rock\u27 Spectrum • Handel\u27s \u27Messiah\u27 to Be Presented Tomorrow • Songfest Tradition Revived • Women\u27s Basketball Lookin\u27 Good • Basketball Off to Slow Start • Football Ends Victorioushttps://digitalcommons.ursinus.edu/grizzlynews/1049/thumbnail.jp

The Grizzly, January 30, 1981

Gambling Investigation Prompts Student Withdrawals • Thornburgh Discusses Education At Conference • Todd Hall Fined $200 For Alcohol Violation • Tower Restoration Scheduled • McQuillan Presents Financial Aid Workshop • Magazine Addresses Students • J-Board Workings Explained By Barth • Fraternity Theories • Bids Distribution • Top Ten Albums of 1980 • Greaseband Unable To Return This Semester • Spiritwood: A Different Coffeehouse • Theatre: A Midsummer Night\u27s Dream • Shipping Delay Postpones NMD Window Installation • Departmental Focus: Health And Physical Education • Swim Coach Hopes For .500 Season • Men\u27s Basketball Holding 1st Place In MAC • Grapplers Having An Up & Down Year • Haag Leads Lady Hoopsters Past Widenerhttps://digitalcommons.ursinus.edu/grizzlynews/1050/thumbnail.jp