Structural plasticity and associative memory in balanced neural networks with spike-time dependent inhibitory plasticity

Peer reviewe

A Suzaku, NuSTAR, and XMM-Newton view on variable absorption and relativistic reflection in NGC 4151

We disentangle X-ray disk reflection from complex line-of-sight absorption in the nearby Seyfert NGC 4151, using a suite of Suzaku, NuSTAR, and XMM-Newton observations. Extending upon earlier published work, we pursue a physically motivated model using the latest angle-resolved version of the lamp-post geometry reflection model relxillCp_lp together with a Comptonization continuum. We use the long-look simultaneous Suzaku/NuSTAR observation to develop a baseline model wherein we model reflected emission as a combination of lamp-post components at the heights of 1.2 and 15.0 gravitational radii. We argue for a vertically extended corona as opposed to two compact and distinct primary sources. We find two neutral absorbers (one full-covering and one partial-covering), an ionized absorber ($\log \xi = 2.8$), and a highly-ionized ultra-fast outflow, which have all been reported previously. All analyzed spectra are well described by this baseline model. The bulk of the spectral variability between 1 keV and 6 keV can be accounted for by changes in the column density of both neutral absorbers, which appear to be degenerate and inversely correlated with the variable hard continuum component flux. We track variability in absorption on both short (2 d) and long ($\sim$1 yr) timescales; the observed evolution is either consistent with changes in the absorber structure (clumpy absorber at distances ranging from the broad line region (BLR) to the inner torus or a dusty radiatively driven wind) or a geometrically stable neutral absorber that becomes increasingly ionized at a rising flux level. The soft X-rays below 1 keV are dominated by photoionized emission from extended gas that may act as a warm mirror for the nuclear radiation.Comment: 21 pages, 19 figures, 8 tables, accepted for publication by A&

Half a Century of Supreme Court Clean Air Act Interpretation: Purposivism, Textualism, Dynamism, and Activism

This Article addresses the history of the Supreme Court’s interpretation of the Clean Air Act, which now goes back almost half a century. Many scholars have argued that the Court has shifted from an approach to statutory interpretation that relied heavily on purposivism—the custom of giving statutory goals weight in interpreting statutes—toward one that relies more heavily on textualism during this period. At the same time, proponents of dynamic statutory interpretation have argued that courts, in many cases, do not so much excavate a statute’s meaning as adapt a statute to contemporary circumstances

Stochastic Transition States: Reaction Geometry amidst Noise

Classical transition state theory (TST) is the cornerstone of reaction rate theory. It postulates a partition of phase space into reactant and product regions, which are separated by a dividing surface that reactive trajectories must cross. In order not to overestimate the reaction rate, the dynamics must be free of recrossings of the dividing surface. This no-recrossing rule is difficult (and sometimes impossible) to enforce, however, when a chemical reaction takes place in a fluctuating environment such as a liquid. High-accuracy approximations to the rate are well known when the solvent forces are treated using stochastic representations, though again, exact no-recrossing surfaces have not been available. To generalize the exact limit of TST to reactive systems driven by noise, we introduce a time-dependent dividing surface that is stochastically moving in phase space such that it is crossed once and only once by each transition path

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530 and D535. To gain information on other regions that will be relevant for vaccine design, we employed yeast surface display of antibodies that bound to genotype 1a H77C E2 mutant proteins containing a substitution either at Y632A (to avoid selecting non-neutralizing antibodies) or D535A. A panel of nine human monoclonal antibodies (HMAbs) was isolated and designated as HC-84-related antibodies. Each HMAb neutralized cell culture infectious HCV (HCVcc) with genotypes 1–6 envelope proteins with varying profiles, and each inhibited E2 binding to the viral receptor CD81. Five of these antibodies neutralized representative genotypes 1–6 HCVcc. Epitope mapping identified a cluster of overlapping epitopes that included nine contact residues in two E2 regions encompassing aa418–446 and aa611–616. Effect on virus entry was measured using H77C HCV retroviral pseudoparticles, HCVpp, bearing an alanine substitution at each of the contact residues. Seven of ten mutant HCVpp showed over 90% reduction compared to wild-type HCVpp and two others showed approximately 80% reduction. Interestingly, four of these antibodies bound to a linear E2 synthetic peptide encompassing aa434–446. This region on E2 has been proposed to elicit non-neutralizing antibodies in humans that interfere with neutralizing antibodies directed at an adjacent E2 region from aa410–425. The isolation of four HC-84 HMAbs binding to the peptide, aa434–446, proves that some antibodies to this region are to highly conserved epitopes mediating broad virus neutralization. Indeed, when HCVcc were passaged in the presence of each of these antibodies, virus escape was not observed. Thus, the cluster of HC-84 epitopes, designated as antigenic domain D, is relevant for vaccine design for this highly diverse virus

The Making of the Finnish Polar Silk Road : Status in Spring 2019

Peer reviewe

Unfolding of eigenvalue surfaces near a diabolic point due to a complex perturbation

The paper presents a new theory of unfolding of eigenvalue surfaces of real symmetric and Hermitian matrices due to an arbitrary complex perturbation near a diabolic point. General asymptotic formulae describing deformations of a conical surface for different kinds of perturbing matrices are derived. As a physical application, singularities of the surfaces of refractive indices in crystal optics are studied.Comment: 23 pages, 7 figure

Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model

► Global levels of ubiquitinated proteins increased in the hippocampus of Tg2576 mice. ► No global changes in either SUMO-1 or SUMO-2/3 conjugation in any brain regions analysed. ► SUMO conjugating and deconjugating enzymes, UBC9 and SENP-1, unaltered in Tg2576 mice. ► Total levels of AMPA and kainate receptors were also unaffected in Tg2576 mice. ► Posttranslational modification by ubiquitin may play a role in Alzheimer's disease

Relationship tensions and mood: Adult children’s daily experience of aging parents’ stubbornness

This study examined middle‐aged individuals’ reports of parents’ behaviors commonly attributed to stubbornness. Middle‐aged adults (N = 192) completed a 7‐day diary reporting their mood and how often they felt their parents (N = 254) engaged in behaviors often described as “stubbornness” (insistent or risky). Thirty‐one percent of middle‐aged children reported insistent behaviors, and 17% reported risky behaviors by their parent(s). Daily reports of parent behaviors attributed to stubbornness were positively associated with parent–child relationship quality, parent functional limitations, and child neuroticism. Reports of perceived parent insistent behaviors were also associated with greater daily negative mood among adult children. Findings highlight the impact of adult children’s daily perceptions of parent behaviors commonly attributed to stubbornness on the individual and relationship.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142899/1/pere12229_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142899/2/pere12229.pd