Strategies to prevent intraoperative lung injury during cardiopulmonary bypass

During open heart surgery the influence of a series of factors such as cardiopulmonary bypass (CPB), hypothermia, operation and anaesthesia, as well as medication and transfusion can cause a diffuse trauma in the lungs. This injury leads mostly to a postoperative interstitial pulmonary oedema and abnormal gas exchange. Substantial improvements in all of the above mentioned factors may lead to a better lung function postoperatively. By avoiding CPB, reducing its time, or by minimizing the extracorporeal surface area with the use of miniaturized circuits of CPB, beneficial effects on lung function are reported. In addition, replacement of circuit surface with biocompatible surfaces like heparin-coated, and material-independent sources of blood activation, a better postoperative lung function is observed. Meticulous myocardial protection by using hypothermia and cardioplegia methods during ischemia and reperfusion remain one of the cornerstones of postoperative lung function. The partial restoration of pulmonary artery perfusion during CPB possibly contributes to prevent pulmonary ischemia and lung dysfunction. Using medication such as corticosteroids and aprotinin, which protect the lungs during CPB, and leukocyte depletion filters for operations expected to exceed 90 minutes in CPB-time appear to be protective against the toxic impact of CPB in the lungs. The newer methods of ultrafiltration used to scavenge pro-inflammatory factors seem to be protective for the lung function. In a similar way, reducing the use of cardiotomy suction device, as well as the contact-time between free blood and pericardium, it is expected that the postoperative lung function will be improved

Comparison of the clinical performance of three digital mammography systems in a breast cancer screening programme

This study compares the clinical performance of three digital mammography system types in a breast cancer screening programme. 28 digital mammography systems from three different vendors were included in the study. The retrospective analysis included 238 182 screening examinations of females aged between 50 and 64 years over a 3-year period. All images were double read and assigned a result according to a 5-point rating scale to indicate the probability of cancer. Females with a positive result were recalled for further assessment imaging and biopsy if necessary. Clinical performance in terms of cancer detection rate was analysed and the results presented. No statistically significant difference was found between the three different mammography systems in a population-based screening programme, in terms of the overall cancer detection rate or in the detection of invasive cancer and ductal carcinoma in situ. This was shown in both prevalent and subsequent screening examination categories. The results demonstrate comparable cancer detection performance for the three imaging system types operational in the screening programme

The frequencies of double- and multiple-break translocations in relation to radiation dose, and other genetical studies

(1) The Frequencies of Double- and Multiple- Break Translocations in relation to Radiation Dose. (2) A Case of Gonosomic Mosaicism involving a Lethal. (3) Genetical Studies of the "Spheroidal" Mutant of Drosohila Funebris

The European network on Neutron Techniques Standardization for Structural Integrity - NeT

This paper provides an overview over the work of the European Network on Neutron Techniques Standardization for Structural Integrity NeT . The network involves some 35 organisations from industry and academia and these partners undertake the application of modern experimental and numerical techniques to problems related to the structural integrity of components, mainly relevant to nuclear applications. While being built around neutron scattering techniques, which are predominantly applied for analyses of welding residual stresses, one of the major strengths of the consortium is the diversity in available experimental and numerical techniques. In the residual stress area, for example, many types of materials characterizations testing, several methods for residual stress analysis, including neutron and Xray diffraction, deep hole drilling, the contour method and others, and many different ways of numerical analysis employing several commercially available FEM codes can be covered by the partners. Currently the network has embarked on five different Task Groups. Four of these are dealing with welding residual stress assessment, and one applies Small Angle Neutron Scattering for studying thermal ageing processes in duplex stainless steels used for reactor core internals. The work already performed in the context of NeT and the envisaged investigations for the ongoing Task Groups are briefly outlined in this paper. The aim is to give the reader a comprehensive overview of the work of NeT and to shed some light on the potential present in this kind of collaborative effor

Quality Controls in Digital Mammography protocol of the EFOMP Mammo Working group

This article aims to present the protocol on Quality Controls in Digital Mammography published online in 2015 by the European Federation of Organisations for Medical Physics (EFOMP) which was developed by a Task Force under the Mammo Working Group. The main objective of this protocol was to define a minimum set of easily implemented quality control tests on digital mammography systems that can be used to assure the performance of a system within a set and acceptable range. Detailed step-by-step instructions have been provided, limiting as much as possible any misinterpretations or variations by the person performing. It is intended that these tests be implemented as part of the daily routine of medical physicists and system users throughout Europe in a harmonised way so allowing results to be compared. In this paper the main characteristics of the protocol are illustrated, including examples, together with a brief summary of the contents of each chapter. Finally, instructions for the download of the full protocol and of the related software tools are provided