Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects

Synthesis and coordination chemistry of scorpionate ligands and their applications in 11C-positron emission tomography

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Synthesis and coordination chemistry of scorpionate ligands and their applications in 11C-positron emission tomography

This thesis is concerned with the synthesis and coordination chemistry of· a range of poly(pyrazolyl)borate 'scorpionate' ligands and examines their suitability in facilitating rapid [llC]carbonylation reactions to form radiotracers for application in positron emission tomography (PET). Author (full names): Steven Kealey Title of thesis: Synthesis and Coordination Chemistry of Scorpionate Ligands and their Applications in He-Positron Emission Tomography The second part of this thesis concerns the use of a copper(I)-Tp system for selectively solubilising llCO from nitrogen-rich gas streams for subsequent use in palladium-catalysed carbonylation reactions between amines and aryl-halides to form amides. These reactions were performed on a microfluidic device and in Schlenk apparatus using unlabelled carbon monoxide. These reactions ~were transferred to the radiochemical laboratory whereby efficient llCO trapping was observed prior to the formation of llC-radiolabelled amides. The third part of this thesis explores the coordination chemistry of palladium(II) towards a novel hybrid ligand consisting of pyrazolyl and triphenylphosphine moieties. The potential hemilabile behaviour of this ligand and its derivatives towards palladium was investigated and the use of these complexes as catalysts for carbonylation reactions is described. The final part of this thesis examines the coordination chemistry of poly(pyrazolyl)borates bearing additional coordinating groups appended to the 3- or 5~position ofthe pyrazolyl rings. Reactions ofthe 3-substituted derivatives were carried out with a range of metals and found to display varied coordination behaviour depending on the specific coordination requirements ofthe metal.EThOS - Electronic Theses Online ServiceGBUnited Kingdo