1,496 research outputs found
Entanglement conditions for multi-mode states
We provide a class of inequalities for detecting entanglements in multi-mode
systems. Necessary conditions for fully separable, bi-separable and sufficient
conditions for fully entangled states are explicitly presented.Comment: 12 page
A New 3D Model-Based Minimal Path Segmentation Method for Kidney MR Images
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Global and partitioned reconstructions of undirected complex networks
It is a significant challenge to predict the network topology from a small
amount of dynamical observations. Different from the usual framework of the
node-based reconstruction, two optimization approaches (i.e., the global and
partitioned reconstructions) are proposed to infer the structure of undirected
networks from dynamics. These approaches are applied to evolutionary games
occurring on both homogeneous and heterogeneous networks via compressed
sensing, which can more efficiently achieve higher reconstruction accuracy with
relatively small amounts of data. Our approaches provide different perspectives
on effectively reconstructing complex networks.Comment: 6 pages, 2 figures, 1 table; revised version; added numerical results
of the PR in Table 1 and expanded Section 4; added 7 reference
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Retinol binding protein 4 promotes hyperinsulinism-induced proliferation of rat aortic smooth muscle cells
Recent studies have suggested that retinol binding protein 4 (RBP4), an adipocytokine related to insulin resistance (IR), may play an important role in the development of atherosclerosis and cardiovascular diseases (CVD). Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is one of the most common causes of atherosclerosis. Hyperinsulinism promotes proliferation of VSMCs through the MAPK pathway. However, whether RBP4 is involved in insulin-induced proliferation of VSMCs leading to atherosclerosis remains unclear. In the present study, we evaluated the role of RBP4 and the potential relevance of signaling pathways in this process. Different concentrations of RBP4 (1 and 4 μg/ml) were added to rat aortic smooth muscle cells (RASMCs) during insulin-induced proliferation. The levels of cell growth signaling pathway proteins ERK1/2, p-ERK1/2, JAK2, p-JAK2, STAT3 and p-STAT3 were assessed by western blotting in order to identify the pathway(s) that are activated during insulin-induced proliferation. The specific inhibitors of ERK1/2 (PD98059) and JAK2 (AG490) were used to confirm our findings. Insulin induced proliferation of RASMCs in a concentration- and time-dependent manner, and increased the expression of ERK1/2, p-ERK1/2, JAK2, p-JAK2, STAT3 and p-STAT3 in a time-dependent manner. RBP4 enhanced insulin-induced proliferation of RASMCs and expression of p-ERK1/2 and p-JAK2. RBP4-induced proliferation of RASMCs was reduced by the ERK1/2 inhibitor, while it was unaffected by the JAK2 inhibitor. These results suggest that RBP4 mediates VSMC proliferation induced by insulin via activation of the MAPK pathway, and highlight RBP4 as a modulator of atherosclerosis in hyperinsulinemia, therby enhancing our understanding on a number of unexpected aspects of CVD
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