The association between gout and cataract risk: A meta-analysis

<div><p>Purpose</p><p>To evaluate the relationship between gout and age-related cataracts (ARCs).</p><p>Methods</p><p>A comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The random-effects model was used instead of the fixed-effects model when heterogeneity was identified, as indicated by a Cochran’s Q statistic P-value <0.10 or I2 index score >50%.</p><p>Results</p><p>A total of 3 cross-sectional studies and 3 case-control studies were included in the meta-analysis. Gout was significantly associated with increased odds of ARCs (OR 1.53, 95% CI 1.27–1.84). In the subgroup analysis, gout exhibited positive associations with the odds of posterior subcapsular cataracts (PSCs, OR 1.69, 95% CI: 1.06–2.70) and cortical cataracts (CCs, OR 1.39, 95% CI: 1.06–1.81). However, no association was identified between gout and the odds of nuclear cataracts.</p><p>Conclusions</p><p>The current literature suggested that gout may be associated with increased odds of ARCs, especially PSCs and CCs. Further efforts should be made to confirm these findings and clarify the effect of gout and gout medications on the development of cataracts.</p></div

Forest plot comparison of CDVA after treatment with FLACS and CPS.

<p>(A) One week. (B) One month. (C) Final follow-up</p

The association of gout with cataract risk in case-control/cross-sectional studies.

<p>The association of gout with cataract risk in case-control/cross-sectional studies.</p

Flow diagram of the literature search in this meta-analysis.

<p>Flow diagram of the literature search in this meta-analysis.</p

Forest plot comparison of MAE of spherical equivalent refraction after treatment with FLACS and CPS.

<p>Forest plot comparison of MAE of spherical equivalent refraction after treatment with FLACS and CPS.</p

Forest plot comparison of UDVA at final follow-up after treatment with FLACS and CPS.

<p>Forest plot comparison of UDVA at final follow-up after treatment with FLACS and CPS.</p

Forest plot comparison of ECL% after treatment with FLACS and CPS.

<p>(A) One week. (B) Three to four weeks. (C) Three months postoperatively.</p

Flow diagram of the literature search in this meta-analysis.

<p>Flow diagram of the literature search in this meta-analysis.</p

Characteristics of included studies.

<p>FLACS, femtosecond laser-assisted cataract surgery; CPS, conventional phacoemulsification surgery; RCT, randomized controlled trial; NA, not available.</p

Characteristics of 6 studies included into present meta-analysis.

<p>Characteristics of 6 studies included into present meta-analysis.</p