Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-5

L of PBS, was administered intraperitoneally. There was a significant difference of survival time between the Ad5MK group and the other groups (p = 0.0002 Log-rank test and p = 0.0002 by Wilcoxson's test).<p><b>Copyright information:</b></p><p>Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer"</p><p>http://www.jeccr.com/content/27/1/30</p><p>Journal of Experimental & Clinical Cancer Research : CR 2008;27(1):30-30.</p><p>Published online 21 Aug 2008</p><p>PMCID:PMC2529268.</p><p></p

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-3

Ells were infected with Ad5GFP or Ad5MK at various MOIs. After 1, 3, and 5 days, the number of viable cells was counted.<p><b>Copyright information:</b></p><p>Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer"</p><p>http://www.jeccr.com/content/27/1/30</p><p>Journal of Experimental & Clinical Cancer Research : CR 2008;27(1):30-30.</p><p>Published online 21 Aug 2008</p><p>PMCID:PMC2529268.</p><p></p

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-0

Sion of midkine protein, whereas BxPC-3, HPAC, and Suit-2 cells showed moderate expression. In contrast, expression by PANC-1 cells was low and MIAPaCa-2 cells showed no detectable midkine band. (B) Midkine mRNA expression in non-cancerous pancreatic tissues and human pancreatic cancers. Expression of midkine mRNA in the pancreatic cancers was significantly stronger than in the non-cancerous pancreatic tissues (p < 0.001).<p><b>Copyright information:</b></p><p>Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer"</p><p>http://www.jeccr.com/content/27/1/30</p><p>Journal of Experimental & Clinical Cancer Research : CR 2008;27(1):30-30.</p><p>Published online 21 Aug 2008</p><p>PMCID:PMC2529268.</p><p></p

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-1

Pressing cells were detected by fluorescence microscopy. (Original magnification ×100).<p><b>Copyright information:</b></p><p>Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer"</p><p>http://www.jeccr.com/content/27/1/30</p><p>Journal of Experimental & Clinical Cancer Research : CR 2008;27(1):30-30.</p><p>Published online 21 Aug 2008</p><p>PMCID:PMC2529268.</p><p></p