Transcranial Magnetic Stimulation with the Maximum Voluntary Muscle Contraction Facilitates Motor Neuron Excitability and Muscle Force

Three trials of transcranial magnetic stimulation (TMS) during the maximum voluntary muscle contraction (MVC) were repeated at 15-minute intervals for 1 hour to examine the effects on motor evoked potentials (MEPs) in the digital muscles and pinching muscle force before and after 4 high-intensity TMSs (test 1 condition) or sham TMS (test 2 condition) with MVC. Under the placebo condition, real TMS with MVC was administered only before and 1 hour after the sham TMS with MVC. Magnetic stimulation at the foramen magnum level (FMS) with MVC was performed by the same protocol as that for the test 2 condition. As a result, MEP sizes in the digital muscles significantly increased after TMS with MVC under test conditions compared with the placebo conditions (P < 0.05). Pinching muscle force was significantly larger 45 minutes and 1 hour after TMS with MVC under the test conditions than under the placebo condition (P < 0.05). FMS significantly decreased MEP amplitudes 60 minutes after the sham TMS with MVC (P < 0.005). The present results suggest that intermittently repeated TMS with MVC facilitates motor neuron excitabilities and muscle force. However, further studies are needed to confirm the effects of TMS with MVC and its mechanism

Rapid reduction in black carbon emissions from China: evidence from 2009–2019 observations on Fukue Island, Japan

A long-term, robust observational record of atmospheric black carbon (BC) concentrations at Fukue Island for 2009–2019 was produced by unifying the data from a continuous soot monitoring system (COSMOS) and a Multi-Angle Absorption Photometer (MAAP). This record was then used to analyze emission trends from China. We identified a rapid reduction in BC concentrations of (−5.8±1.5) % yr−1 or −48 % from 2010 to 2018. We concluded that an emission change of (−5.3±0.7) % yr−1, related to changes in China of as much as −4.6 % yr−1, was the main underlying driver. This evaluation was made after correcting for the interannual meteorological variability (IAV) by using the regional atmospheric chemistry model simulations from the Weather Research and Forecasting (WRF) and Community Multiscale Air Quality (CMAQ) models (collectively WRF/CMAQ) with the constant emissions. This resolves the current fundamental disagreements about the sign of the BC emissions trend from China over the past decade as assessed from bottom-up emission inventories. Our analysis supports inventories reflecting the governmental clean air actions after 2010 (e.g., MEIC1.3, ECLIPSE versions 5a and 6b, and the Regional Emission inventory in ASia (REAS) version 3.1) and recommends revisions to those that do not (e.g., Community Emissions Data System – CEDS). Our estimated emission trends were fairly uniform across seasons but diverse among air mass origins. Stronger BC reductions, accompanied by a reduction in carbon monoxide (CO) emissions, occurred in regions of south-central East China, while weaker BC reductions occurred in north-central East China and northeastern China. Prior to 2017, the BC and CO emissions trends were both unexpectedly positive in northeastern China during winter months, which possibly influenced the climate at higher latitudes. The pace of the estimated emissions reduction over China surpasses the Shared Socioeconomic Pathways (SSPs with reference to SSP1, specifically) scenarios for 2015–2030, which suggests highly successful emission control policies. At Fukue Island, the BC fraction of fine particulate matter (PM2.5) also steadily decreased over the last decade. This suggests that reductions in BC emissions started without significant delay when compared to other pollutants such as NOx and SO2, which are among the key precursors of scattering PM2.5

Development of the Curriculum for the Connection Period of an Elementary School and a Junior High School : Through Teachers in Kindergarten Joining Classes at Elementary School

本研究は，幼稚園教員・小学校教員がそれぞれの校種の保育・授業に参観・参加し，それぞれの専門性を活かして交流することを通し，幼小接続期におけるカリキュラムの開発に向けた基礎的情報を得ることを目的とする。特に，本研究では幼稚園教員による１年生の授業参加を通して認識した共通点・差異点に着目する。研究の方法としては，幼稚園教員が小学校１年生の生活科・音楽科の授業にＴ２として参加し，他の幼稚園教員は参観する。その後，幼稚園教員に対して質問紙調査を実施した。また，生活科・音楽科の授業後に，幼稚園教員と小学校教員で授業参加に関する研究協議を実施した。結果としては，次の３点である。１点目は，ねらいによって，受容・共感の言葉がけやねらいに向けて展開していく言葉がけが必要である。２点目は，幼稚園教師は子どもの成長を見ており，小学校教師は子どもを教科の枠で見ていることに違いがあり，この点に関しては接続期において配慮することが必要である。３点目は，ねらいが幼小で同じようでも活動の展開の仕方に違いがあり，子どもの発達に応じて活動の展開を工夫することが必要である。The purpose of this study was to develop a connective curriculum between kindergarten and elementary school. To achieve this, the differences between kindergarten and elementary school teachers were investigated. Kindergarten teachers participated in a music or a human life and science class in a team teaching staff or as observers. After this experiences, participants were asked some open-ended questions. The main results are as follows: (1) it is important to express sympathy to and adoption of the aims and goals of the class a; (2) kindergarten teachers tend to focus on the growth of children, compared with elementary school teachers, who focus on the goal of the class; (3) there are differences in the ways of conducting teaching activities even when the aims of classes are same

Resected Intrahepatic Cholangiocarcinoma with Anaphylactic Shock from a Preoperative Liver Function Test before Hepatectomy

The indocyanine green test is a reliable liver function examination before major hepatectomy, and anaphylaxis is rarely a concern. A 65-year-old male patient without epigastralgia was diagnosed with a 2.2-cm intrahepatic cholangiocarcinoma. He had no history of allergic reactions. Some liver dysfunction was indicated by the laboratory data; however, there was no marked obstructive jaundice and the liver functional reserve was maintained by technetium-99m galactosyl serum albumin. The indocyanine green test was routinely performed, but the patient immediately demonstrated severe anaphylaxis due to indocyanine green administration. He had cardiorespiratory arrest, but recovered after immediate resuscitation. Although acute renal and respiratory failure was significant, the patient recovered at day 10 after the event, and his liver function and other organ functions were improved. Then, the scheduled left hepatectomy with caudate and extrahepatic duct resection was successfully performed without issues. The patient exhibited no allergic response against the administration of antibiotics or other drugs and the postoperative course was uneventful. The patient was discharged on day 17. The tumor was diagnosed as stage III intrahepatic cholangiocarcinoma and R0 resection was accomplished. Preoperative management, including the liver functional loading test, should be carefully carried out before major hepatectomy