17 research outputs found
Ruptured hepatic metastases of cutaneous melanoma during treatment with vemurafenib: an autopsy case report
Full text linkCharacterization of Thiamin Phosphate Kinase in the Hyperthermophilic Archaeon <i>Pyrobaculum calidifontis</i>
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The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues
No full textThe burkholdines are a family of cyclic lipopeptides reported to exhibit antifungal activity. We synthesized a series of 18 burkholdine analogues in good yield by conventional Fmoc-SPPS followed by cyclization with DIPCI/HOBt in the solution phase. Although none of the synthesized peptides exhibited antifungal activity, several did potentiate the antibiotic effect of the antibiotic G418, including the Thr-bearing Bk analogue (4b) and the tartaramide-bearing Bk analogue (5b). This work exemplifies the potential of burkholdine analogues as potentiating agents
Convergent Synthesis of <i>trans</i>-2,6-Disubstituted Piperidine Alkaloid, (−)-<i>iso</i>-6-Spectaline by Palladium-Catalyzed Cyclization
No full textSa1338 – Development of a Novel Circulating Tumor Cells Isolation System in Patients with Pancreatic Cancer Using a Microcavity Array
No full textDaily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients
No full textThe Usefulness of Video Capsule Endoscopy in Evaluating Gastrointestinal Manifestations of Immunoglobulin A Vasculitis
No full textHeat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial
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