1 research outputs found
Total Synthesis of <i>ent</i>-Ascospiroketal B
Ascospiroketal B was isolated from
a marine-derived fungus as a
structurally unique polyketide possessing a rare tricyclic core including
5,5-spiroketal-γ-lactone. An asymmetric total synthesis of <i>ent</i>-ascospiroketal B was achieved using an original synthetic
route. The synthesis included the stereoselective construction of
5,5-spiroketal for ascospiroketal B and stereocontrolled construction
of a quaternary asymmetric carbon by rearrangement of a trisubstituted
epoxide