7 research outputs found
Bistinospinosides A and B, Dimeric Clerodane Diterpene Glycosides from <i>Tinospora sagittata</i>
Two dimeric clerodane diterpene glycosides,
namely, bistinospinosides
A (<b>1</b>) and B (<b>2</b>), were isolated from the
roots of <i>Tinospora sagittata</i>. Their structures were
elucidated by extensive spectroscopic data interpretation. The compounds
feature an unusual 1,4-epoxycyclohexane ring in their structures and
may be biosynthetically constructed via an intermolecular Diels–Alder
[4+2] cycloaddition from the corresponding clerodane diterpene. The
compounds were evaluated in a nitric oxide inhibitory assay using
J774.1 macrophage-like cells
A new minor homoisoflavonoid from <i>Caesalpinia sappan</i>
<div><p>Homoisoflavonoid is a special type of flavonoid with the perspectives of both chemical diversity and significant biological activities. During our ongoing studies on the discovery of novel homoisoflavonoids from traditional Chinese medicines, a new minor 3,4-di-<i>O</i>-substituted homoisoflavonoid, 3′,4-di-<i>O</i>-methylepisappanol (<b>1</b>), was isolated from <i>Caesalpinia sappan</i>, and its structure was determined to be (3<i>R</i>,4<i>R</i>)-3,7-dihydroxy-3-(3′-methoxy-4′-hydroxybenzyl)-4-methoxychroman by various spectroscopic analyses. Meanwhile, a known xanthone derivate, 2-methoxy-3-hydroxyxanthone (<b>2</b>) was also isolated, which is the first example from the genus <i>Caesalpinia</i>.</p></div
Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from <i>Edgeworthia chrysantha</i>
Edgeworthianins A–E (1–5) were isolated from Edgeworthia chrysantha as a
class of macrocyclic daphnane orthoesters with an unusual macrocyclic
ring formed from a C14 aliphatic chain. Their structures were elucidated
by extensive physicochemical and spectroscopic analyses. Compounds 2, 4, and 5 exhibited potent anti-HIV
activity against HIV-1 infection of MT4 cells with EC50 values of 29.3, 8.4, and 2.9 nM, respectively. These compounds broaden
the findings of the structure–activity relationship of macrocyclic
daphnane orthoesters for further anti-HIV drug development
Anti-steatosis compounds from leaves of <i>Mallotus furetianus</i>
<p>There is no drug administration-approved therapy for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, eight compounds, gallic acid (<b>1</b>), methyl gallate (<b>2</b>), corilagin (<b>3</b>), 3,4,8,9,10-pentahydroxydibenzo[<i>b,d</i>]pyran-6-one (<b>4</b>), repandinin B (<b>5</b>), (Z)-3-hexenyl-β-D-glucopyranoside (<b>6</b>), (+)-lyoniresinol-3α-O-α-L-rhamnopyranoside (<b>7</b>) and mallophenol A (<b>8</b>) were isolated from the active fractions of <i>Mallotus furetianus</i>. Three compounds, (<b>6, 7</b> and <b>8</b>) revealed potent anti-steatosis activity in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05 (<b>6</b>), 0.0005 (<b>7</b>) and 0.0005 (<b>8</b>) μg/mL, which were much lower than the control compound, fibrate (72.4 μg/mL).</p
Isolation, Structural Elucidation, and Liquid Chromatography–Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum
The
rhizomes of Polygonatum odoratum represent
a traditional Chinese medicine and functional food. A
phytochemical investigation resulted in the isolation of eight steroidal
glycosides (<b>1</b>–<b>8</b>), including two new
compounds, polygonatumosides F (<b>1</b>) and G (<b>2</b>). The structures were elucidated by spectroscopic data and chemical
reactions. Compound <b>7</b> showed antiproliferation activity
against human hepatocellular carcinoma cell line HepG2 (IC<sub>50</sub> of 3.2 μM). The chemical profile and contents of steroidal
glycosides of P. odoratum rhizomes
collected at different dates and geographical locations were also
investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to
obtain higher levels of steroidal glycosides. Compounds <b>1</b> and <b>7</b> showed the highest contents in all P. odoratum samples and have potential to serve as
chemotaxonomic and chemical markers for quality control of this important
plant material. 14-Hydroxylation may be a key step for the biosynthesis
of compounds <b>1</b>–<b>7</b>
Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from <i>Stellera chamaejasme</i>
Five novel tigliane-type diterpenes,
stelleracins A–E (<b>3</b>–<b>7</b>), a
novel flavanone dimer, chamaeflavone
A (<b>8</b>), and six known compounds were isolated from the
roots of <i>Stellera chamaejasme</i>. Their structures were
elucidated by extensive spectroscopic analyses. The isolated compounds
were evaluated for anti-HIV activity in MT4 cells. New compounds <b>3</b>–<b>5</b> showed potent anti-HIV activity (EC<sub>90</sub> 0.00056–0.0068 μM) and relatively low or no
cytotoxicity (IC<sub>50</sub> 4.4–17.2 μM). These new
compounds represent promising new leads for development into anti-AIDS
clinical trial candidates
Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from <i>Stellera chamaejasme</i>
Five novel tigliane-type diterpenes,
stelleracins A–E (<b>3</b>–<b>7</b>), a
novel flavanone dimer, chamaeflavone
A (<b>8</b>), and six known compounds were isolated from the
roots of <i>Stellera chamaejasme</i>. Their structures were
elucidated by extensive spectroscopic analyses. The isolated compounds
were evaluated for anti-HIV activity in MT4 cells. New compounds <b>3</b>–<b>5</b> showed potent anti-HIV activity (EC<sub>90</sub> 0.00056–0.0068 μM) and relatively low or no
cytotoxicity (IC<sub>50</sub> 4.4–17.2 μM). These new
compounds represent promising new leads for development into anti-AIDS
clinical trial candidates