MOESM3 of Exponential distribution of total depressive symptom scores in relation to exponential latent trait and item threshold distributions: a simulation study

Additional file 3. Raw data for all figures

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

03 février 19431943/02/03 (A44,N15339)

CES-D distributions for the middle adulthood groups (left).

<p>The right tails of the distributions for middle adulthood were compared using a log-normal scale (right).</p

The distributions of the 16 negative items were compared using a normal scale (left) and a log-normal scale (right).

<p>The distributions of the 16 negative items were compared using a normal scale (left) and a log-normal scale (right).</p

Distributions of the item responses for the depressive mood group (upper left), the somatic symptoms and retarded activities group (upper right), the interpersonal relations group (bottom left), and the positive affect group (bottom right).

<p>Distributions of the item responses for the depressive mood group (upper left), the somatic symptoms and retarded activities group (upper right), the interpersonal relations group (bottom left), and the positive affect group (bottom right).</p

Effects of Green Tea Gargling on the Prevention of Influenza Infection in High School Students: A Randomized Controlled Study

<div><p>Background</p><p>The anti-influenza virus activity of green tea catechins has been demonstrated in experimental studies, but clinical evidence has been inconclusive. School-aged children play an important role in the infection and spread of influenza in the form of school-based outbreaks. Preventing influenza infection among students is essential for reducing the frequency of epidemics and pandemics. As a non-pharmaceutical intervention against infection, gargling is also commonly performed in Asian countries but has not yet been extensively studied.</p><p>Methods and Findings</p><p>A randomized, open label, 2-group parallel study of 757 high school students (15 to 17 years of age) was conducted for 90 days during the influenza epidemic season from December 1st, 2011 to February 28th, 2012, in 6 high schools in Shizuoka Prefecture, Japan. The green tea gargling group gargled 3 times a day with bottled green tea, and the water gargling group did the same with tap water. The water group was restricted from gargling with green tea. The primary outcome measure was the incidence of laboratory-confirmed influenza using immunochromatographic assay for antigen detection. 757 participants were enrolled and 747 participants completed the study (384 in the green tea group and 363 in the water group). Multivariate logistic regression indicated no significant difference in the incidence of laboratory-confirmed influenza between the green tea group (19 participants; 4.9%) and the water group (25 participants; 6.9%) (adjusted OR, 0.69; 95%CI, 0.37 to 1.28; <i>P</i> = 0.24). The main limitation of the study is the adherence rate among high school students was lower than expected.</p><p>Conclusions</p><p>Among high school students, gargling with green tea three times a day was not significantly more efficacious than gargling with water for the prevention of influenza infection. In order to adequately assess the effectiveness of such gargling, additional large-scale randomized studies are needed.</p><p>Trial Registration</p><p>ClinicalTrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT01225770" target="_blank">NCT01225770</a></p></div

Kaplan-Meier curves for clinically-defined influenza.

<p>(A) Full analysis set, (B) Per protocol set.</p

Baseline characteristics of study participants.

<p>Abbreviation: BMI, body mass index.</p>†<p><i>P</i> value based on Student’s <i>t</i>-test.</p>‡<p><i>P</i> value based on Mann-Whitney U test.</p>§<p>P value based on chi-square test.</p>††<p>Hand washing and facemasks performed 4 days per week or more during study period.</p>–∥<p>Green tea drinking habit defined as drinking over 200 mL (one cup) of green tea per day.</p

Additional file 1: of Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

CONSORT 2010 checklist of information to include when reporting a randomised trial. (DOC 217 kb

Flow diagram for study.

<p>Flow diagram for study.</p