On the High--Velocity Ejecta of the Type Ia Supernova 1994D

Synthetic spectra generated with the parameterized supernova synthetic-spectrum code SYNOW are compared to spectra of the Type Ia SN 1994D that were obtained before the time of maximum brightness. Evidence is found for the presence of two-component Fe II and Ca II features, forming in high velocity ($\ge 20,000$ \kms) and lower velocity ($\le 16,000$ \kms) matter. Possible interpretations of these spectral splits, and implications for using early--time spectra of SNe Ia to probe the metallicity of the progenitor white dwarf and the nature of the nuclear burning front in the outer layers of the explosion, are discussed.Comment: 15 pages, 3 figures, 3 tables, Astrophysical Journal, in pres

On the Spectroscopic Diversity of Type Ia Supernovae

A comparison of the ratio of the depths of two absorption features in the spectra of TypeIa supernovae (SNe Ia) near the time of maximum brightness with the blueshift of the deep red Si II absorption feature 10 days after maximum shows that the spectroscopic diversity of SNe Ia is multi-dimensional. There is a substantial range of blueshifts at a given value of the depth ratio. We also find that the spectra of a sample of SNe Ia obtained a week before maximum brightness can be arranged in a ``blueshift sequence'' that mimics the time evolution of the pre-maximum-light spectra of an individual SN Ia, the well observed SN 1994D. Within the context of current SN Ia explosion models, we suggest that some of the SNe Ia in our sample were delayed-detonations while others were plain deflagrations.Comment: accepted for publication in ApJ

Di-neutron correlation and soft dipole excitation in medium mass neutron-rich nuclei near drip-line

The neutron pairing correlation and the soft dipole excitation in medium-mass nuclei near drip-line are investigated from a viewpoint of the di-neutron correlation. Numerical analyses by means of the coordinate-space HFB and the continuum QRPA methods are performed for even-even $^{18-24}$O, $^{50-58}$Ca and $^{80-86}$Ni. A clear signature of the di-neutron correlation is found in the HFB ground state; two neutrons are correlated at short relative distances \lesim 2 fm with large probability $\sim 50$. The soft dipole excitation is influenced strongly by the neutron pairing correlation, and it accompanies a large transition density for pair motion of neutrons. This behavior originates from a coherent superposition of two-quasiparticle configurations $[l\times (l+1)]_{L=1}$ consisting of continuum states with high orbital angular momenta $l$ reaching an order of $l\sim 10$. It raises a picture that the soft dipole excitation under the influence of neutron pairing is characterized by motion of di-neutron in the nuclear exterior against the remaining $A-2$ subsystem. Sensitivity to the density dependence of effective pair force is discussed.Comment: 35 pages, 22 figure

Extinction and the Radial Distribution of Supernova Properties in Their Parent Galaxies

We use a Monte Carlo technique and assumed spatial distributions of dust and supernova (SN) progenitors in a simple model of a characteristic SN--producing disk galaxy to explore the effects of extinction on the radial distributions of SN properties in their parent galaxies. The model extinction distributions and projected radial number distributions are presented for various SN types. Even though the model has no core-collapse SNe within three kpc of the center, a considerable fraction of the core-collapse SNe are projected into the inner regions of inclined parent galaxies owing to their small vertical scale height. The model predicts that because of extinction, SNe projected into the central regions should on average appear dimmer and have a much larger magnitude scatter than those in the outer regions. In particular, the model predicts a strong deficit of bright core-collapse events inside a projected radius of a few kpc. Such a deficit is found to be present in the observations. It is a natural consequence of the characteristic spatial distributions of dust and core-collapse SNe in galaxies, and it leads us to offer an alternative to the conventional interpretation of the Shaw effect.Comment: 14 pages, 4 figure

Direct Analysis of Spectra of the Peculiar Type Ia Supernova 2000cx

The Type Ia SN 2000cx exhibited multiple peculiarities, including a lopsided B-band light-curve peak that does not conform to current methods for using shapes of light curves to standardize SN Ia luminosities. We use the parameterized supernova synthetic-spectrum code SYNOW to study line identifications in the photospheric-phase spectra of SN 2000cx. Previous work established the presence of Ca II infrared-triplet features forming above velocity about 20,000 km/s, much higher than the photospheric velocity of about 10,000 km/s. We find Ti II features forming at the same high velocity. High-velocity line formation is partly responsible for the photometric peculiarities of SN 2000cx: for example, B-band flux blocking by Ti II absorption features that decreases with time causes the B light curve to rise more rapidly and decline more slowly than it otherwise would. SN 2000cx contains an absorption feature near 4530 A that may be H-beta, forming at the same high velocity. The lack of conspicuous H-alpha and P-alpha signatures does not necessarily invalidate the H-beta identification if the high-velocity line formation is confined to a clump that partly covers the photosphere and the H-alpha and P-alpha source functions are elevated relative to that of resonance scattering. The H-beta identification is tentative. If it is correct, the high-velocity matter must have come from a nondegenerate companion star.Comment: 41 pages including 21 figures, accepted by Ap

The biomechanical implications of neck position in cervical contusion animal models of SCI

Large animal contusion models of spinal cord injury are an essential precursor to developing and evaluating treatment options for human spinal cord injury. Reducing variability in these experiments has been a recent focus as it increases the sensitivity with which treatment effects can be detected while simultaneously decreasing the number of animals required in a study. Here, we conducted a detailed review to explore if head and neck positioning in a cervical contusion model of spinal cord injury could be a factor impacting the biomechanics of a spinal cord injury, and thus, the resulting outcomes. By reviewing existing literature, we found evidence that animal head/neck positioning affects the exposed level of the spinal cord, morphology of the spinal cord, tissue mechanics and as a result the biomechanics of a cervical spinal cord injury. We posited that neck position could be a hidden factor contributing to variability. Our results indicate that neck positioning is an important factor in studying biomechanics, and that reporting these values can improve inter-study consistency and comparability and that further work needs to be done to standardize positioning for cervical spinal cord contusion injury models

The Type Ic Hypernova SN 2002ap

Photometric and spectroscopic data of the energetic Type Ic supernova (SN) 2002ap are presented, and the properties of the SN are investigated through models of its spectral evolution and its light curve. The SN is spectroscopically similar to the "hypernova" SN 1997ef. However, its kinetic energy [$\sim (4-10) \times 10^{51}$ erg] and the mass ejected (2.5-5 $M_{\odot}$) are smaller, resulting in a faster-evolving light curve. The SN synthesized $\sim 0.07 M_{\odot}$ of $^{56}$Ni, and its peak luminosity was similar to that of normal SNe. Brightness alone should not be used to define a hypernova, whose defining character, namely very broad spectral features, is the result of a high kinetic energy. The likely main-sequence mass of the progenitor star was 20-25 $M_{\odot}$, which is also lower than that of both hypernovae SNe 1997ef and 1998bw. SN 2002ap appears to lie at the low-energy and low-mass end of the hypernova sequence as it is known so far. Observations of the nebular spectrum, which is expected to dominate by summer 2002, are necessary to confirm these values.Comment: 10 pages, 4 figures, accepted for publication in ApJL, 30 April 2002 (minor changes to match the accepted version, with figures being colored

Resonant Andreev reflections in superconductor-carbon-nanotube devices

Resonant Andreev reflection through superconductor-carbon-nanotube devices was investigated theoretically with a focus on the superconducting proximity effect. Consistent with a recent experiment, we find that for high transparency devices on-resonance, the Andreev current is characterized by a large value and a resistance dip; low-transparency off-resonance devices give the opposite result. We also give evidence that the observed low-temperature transport anomaly may be a natural result of Andreev reflection process

Readministration of gefitinib in a responder after treatment discontinuation due to gefinitib-related interstitial lung disease: a case report

<p>Abstract</p> <p>Introduction</p> <p>Gefitinib is a new molecular-targeted agent for the treatment of patients with advanced non-small cell lung cancer that fail to respond to conventional chemotherapy. Gefitinib is considered to be well tolerated and less toxic compared with conventional cytotoxic drugs. However, interstitial lung disease (ILD) has been reported as a serious adverse effect. The precise management of a gefitinib responder having severe adverse events remains unknown.</p> <p>Case Presentation</p> <p>We report the case of gefitinib readministration in a patient with lung adenocarcinoma who had once responded but in whom treatment had to be discontinued owing to gefinitib-related ILD. A dramatic response was achieved both at the time of initial treatment (250 mg/day) and at readministration of gefitinib (125 mg/day). The effectiveness of gefitinib therapy in our patient could be explained in part by the presence of an activating mutation of epidermal growth factor receptor (<it>EGFR</it>) gene, L858R in exon 21, which was identified in the primary tumor.</p> <p>Conclusion</p> <p>A reduced dose of gefitinib might be sufficient for patients having tumors with <it>EGFR </it>gene mutations, and that the currently approved dose may be excessively potent in some of these patients, thus resulting in the onset of adverse events.</p

Direct Analysis of Spectra of Type Ib Supernovae

Synthetic spectra generated with the parameterized supernova synthetic-spectrum code SYNOW are compared to photospheric-phase spectra of Type Ib supernovae (SNe Ib). Although the synthetic spectra are based on many simplifying approximations, including spherical symmetry, they account well for the observed spectra. Our sample of SNe Ib obeys a tight relation between the velocity at the photosphere, as determined from the Fe II features, and the time relative to that of maximum light. From this we infer that the masses and the kinetic energies of the events in this sample were similar. After maximum light the minimum velocity at which the He I features form usually is higher than the velocity at the photosphere, but the minimum velocity of the ejected helium is at least as low as 7000 kms. Previously unpublished spectra of SN 2000H reveal the presence of hydrogen absorption features, and we conclude that hydrogen lines also were present in SNe 1999di and 1954A. Hydrogen appears to be present in SNe Ib in general, although in most events it becomes too weak to identify soon after maximum light. The hydrogen-line optical depths that we use to fit the spectra of SNe 2000H, 1999di, and 1954A are not high, so only a mild reduction in the hydrogen optical depths would be required to make these events look like typical SNe Ib. Similarly, the He I line optical depths are not very high, so a moderate reduction would make SNe Ib look like SNe Ic.Comment: 21 pages and 24 figures, submitted to Ap