Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US) demonstrated unique enhancement in the late vascular phase, which was incompatible with those observed in hepatocellular carcinoma, cholangiocellular carcinoma, or metastatic adenocarcinoma. The patient underwent surgical resection of the tumor followed by systemic chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP), while radiation chemotherapy was not applied because of relatively poor performance status. Although postoperative image analysis revealed no recurrence 4 months later, the patient died 13 months after the operation from recurrence. Immunohistological analysis of the resected specimen revealed that this SCC contained many capillary endothelial vessels expressing CD31 or CD34, possibly reflecting the unique imaging pattern in the late vascular phase of CE-US, which has been reported in choangiolocellular carcinoma. In addition, we reviewed which kind of treatment would be suitable for advanced hepatic primary SCC in the literature. From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver

PRECISE TRANSITION FREQUENCY MEASUREMENTS OF CH4CH_{4} IN THE 1.66μm1.66 \mu m REGION

$^{a}$C. Ishibashi and H. Sasada, Proc. of 54th Ohio State Univ. Int. Symp. Molec. Spectrosc. RJ04, 237 (1999) $^{b}$C. Ishibashi and H. Sasada, Jpn. J. Appl. Phys. 38, 920 (1999) $^{c}$K. Suzumura, C. Ishibashi, and H. Sasada. Opt. Lett. 22, 1356 (1999) $^{d}$C. Ishibashi, M. Kourogi. K. Imai, B. Widiyatmoko. A. Onae, and H. Sasada, Opt. Commun. 161, 223 (1999)Author Institution: Department of Physics, Faculty of Science and Technology, Keio University; Graduate School at Nagatsuta, Tokyo Institute of Technology; Graduate School at Nagatsuta, National Research Laboratory of MetrologySub-Doppler resolution laser spectroscopy with high sensitivity and wide tunability was presented by some of the authors (C.I. and H.S.) last $year^{a}$. There we used a Fabry-Perot cavity absorption cell, an external-cavity diode laser (ECDL), and a frequency modulation technique, which drastically improved the performance of the $spectrometer^{b}$. Because the spectral resolution was attained as high as 320 kHz, the corresponding precision has been required in the frequency measurement. To this end, we stabilized the ECDL's frequency to the narrow saturation dip of $CH_{4}$ of the $2\nu_{3}$ band in the $1.66 \mu m$ region, and made two kinds of precise frequency measurements. First, we stabilized two ECDL's frequency to different spectral lines respectively, and measured the frequency of the optical beat note between the ECDL's. Sixty-six frequency differences were measured with an accuracy of 40 $kHz.^{c}$ The second is the absolute frequency measurement. We used a $1.54- \mu m$ saturated absorption line of $^{13}C_{2}H_{2}$ as a frequency reference and an optical frequency comb generator for bridging the 14-THz frequency gap between the $1.66 \mu m$ and $1.54 \mu m$ radiations. The absolute frequencies of the R(0) and Q(1) transitions were determined to be 180.345 065 08(37) and 180.021 253 10(61) THz, respectively.$^{d}

Hepatectomy for Hilar Cholangiocarcinoma with Right-Sided Ligamentum Teres Using a Hepatectomy Simulation System

Right-sided ligamentum teres (RSLT) is a rare congenital anomaly often accompanied by variation of the hepatic vasculature. We herein report a surgical case of a hilar cholangiocarcinoma with RSLT in whom preoperative hepatectomy simulation proved useful for understanding the anatomical structure of the liver. A 78-year-old male with obstructive jaundice was referred to our department for further examination. The patient was suspected of having a hilar cholangiocarcinoma originating from the left hepatic bile duct by contrast-enhanced computed tomography (CT), and CT also showed right umbilical portion (RUP). Three-dimensional images of the hepatic vasculature and biliary system reconstructed using a hepatectomy simulation system suggested that all portal branches ramified from RUP were right paramedian branches, and three leftward portal branches from these ran parallel to the peripheral bile ducts confluent with the left hepatic bile duct, where the tumor was present. Hepatic resection of part of the ventral area of the right paramedian sector and left hemiliver was performed along the demarcation line drawn after clamping the portal branches; the ratio of estimated liver resection volume was 28.9%. After the operation, bile leakage occurred. However, the leakage was treated with percutaneous drainage alone, and the patient was discharged 77 days after the operation. The patient is doing well without any signs of recurrence 21 months after the operation. The vascular and biliary anatomy in patients with RSLT is complicated and should be evaluated in detail preoperatively using a hepatectomy simulation system