Kansai University Library 100th anniversary

目次 【序文】記念誌の刊行にあたって（図書館長　内田慶市）図書館創設100周年によせて（学長　楠見晴重）記念誌の編集について【第1部　この20年を振り返って】高槻図書室開館（広瀬雅子）…3阪神・淡路大震災（高橋真澄）…8図書館システムの変遷（徳岡久実・濱生快彦）…12図書館ビジョン7項目の制定（濱生快彦）…20図書館におけるアウトソーシング（高橋真澄）…26電子展示（濱生快彦）…36市民利用開始（広瀬雅子）…41図書館ウェブサイト（濱生快彦）…442010プロジェクトによる新図書館（高橋真澄・田中恵美）…48図書館リニューアル工事（新谷大二郎）…60図書館の現在と未来（堀口和弘）…68【第2部　図書館に想う】関西大学図書館創設100周年に寄せて（市川訓敏）…79図書館の思い出、図書館への思い（北川勝彦）…85図書館在職時の思い出（柴田真一）…91数々の貴重書（田中登）…95関西大学図書館100周年にあたって : 私の夢想する図書館（内田慶市）…100【第3部　図書館の文庫・コレクション】文庫・コレクションの紹介（鵜飼香織）…111【第4部　資料編】図書館年譜（明治19.3 ～平成26.7）…119サービスに係る統計（総合図書館）…146サービスに係る統計（高槻図書室・ミューズ大学図書館・堺キャンパス図書館）…148蔵書数の推移…149図書費執行額の推移…150展示一覧…152他大学図書館との協定一覧…160【「図書館コラム」】新人時代の思い出（高松和美）…11エレベーターにまつわる話（吉田有輝）…19泣き別れたり、親子になったり（嶋田有理香）…35貴重なのは本だけ？貴重書担当のつぶやき（大上良樹）…40会長校のころ（金東瀅）…46『コアラ博士』にまつわるあれこれ（松本和剛）…57広報誌『KULione 』誕生秘話（白髪友賀）…59本と夢を運んだテレリフト（芝谷秀司）…66LOUIS VUITTON（加藤博之）…7

Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology

Summary: Cells cease to proliferate above their growth-permissible temperatures, a ubiquitous phenomenon generally attributed to heat damage to cellular macromolecules. We here report that, in the presence of rapamycin, a potent inhibitor of Target of Rapamycin Complex 1 (TORC1), the fission yeast Schizosaccharomyces pombe can proliferate at high temperatures that usually arrest its growth. Consistently, mutations to the TORC1 subunit RAPTOR/Mip1 and the TORC1 substrate Sck1 significantly improve cellular heat resistance, suggesting that TORC1 restricts fission yeast growth at high temperatures. Aiming for a more comprehensive understanding of the negative regulation of high-temperature growth, we conducted genome-wide screens, which identified additional factors that suppress cell proliferation at high temperatures. Among them is Mks1, which is phosphorylated in a TORC1-dependent manner, forms a complex with the 14-3-3 protein Rad24, and suppresses the high-temperature growth independently of Sck1. Our study has uncovered unexpected mechanisms of growth restraint even below the temperatures deleterious to cell physiology

Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology

Cells cease to proliferate above their growth-permissible temperatures, a ubiquitous phenomenon generally attributed to heat damage to cellular macromolecules. We here report that, in the presence of rapamycin, a potent inhibitor of Target of Rapamycin Complex 1 (TORC1), the fission yeast Schizosaccharomyces pombe can proliferate at high temperatures that usually arrest its growth. Consistently, mutations to the TORC1 subunit RAPTOR/Mip1 and the TORC1 substrate Sck1 significantly improve cellular heat resistance, suggesting that TORC1 restricts fission yeast growth at high temperatures. Aiming for a more comprehensive understanding of the negative regulation of high-temperature growth, we conducted genome-wide screens, which identified additional factors that suppress cell proliferation at high temperatures. Among them is Mks1, which is phosphorylated in a TORC1-dependent manner, forms a complex with the 14-3-3 protein Rad24, and suppresses the high-temperature growth independently of Sck1. Our study has uncovered unexpected mechanisms of growth restraint even below the temperatures deleterious to cell physiology